Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulations

This work proposes a sequential injection analysis (SIA) system for the spectrophotometric determination of norfloxacin (NOR) and ciprofloxacin (CIP) in pharmaceutical formulations. The methodology was based on the reaction of these drugs with p-(dimethylamino)cinnamaldehyde in micellar medium, prod...

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Autores: Rufino, José Luiz [UNESP], Pezza, Helena Redigolo [UNESP], Pezza, Leonardo [UNESP], Pinto, Paula C. A. G., Saraiva, M. Lúcia M. F. S., Lima, José L. F. C.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:Brasil
Recursos:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/26291
Acesso em linha:http://dx.doi.org/10.1590/S0100-40422011000200016
http://hdl.handle.net/11449/26291
Access Level:acceso abierto
Palavra-chave:sequential injection analysis
spectrophotometry
pharmaceutical formulations
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spelling Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulationssequential injection analysisspectrophotometrypharmaceutical formulationsThis work proposes a sequential injection analysis (SIA) system for the spectrophotometric determination of norfloxacin (NOR) and ciprofloxacin (CIP) in pharmaceutical formulations. The methodology was based on the reaction of these drugs with p-(dimethylamino)cinnamaldehyde in micellar medium, producing orange colored products (λmax = 495 nm). Beer´s law was obeyed in the concentration range from 2.75x10-5 to 3.44x10-4 mol L-1 and 3.26x10-5 to 3.54x10-4 mol L-1 for NOR and CIP, respectively and sampling rate was 25 h-1. Commercial samples were analyzed and results obtained through the proposed method were in good agreement with those obtained using the reference procedure for a 95% confidence level.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual de São Paulo Instituto de Química de AraraquaraUniversidade do Porto Faculdade de Farmácia Departamento de Química-FísicaSociedade Brasileira de QuímicaUniversidade Estadual Paulista (Unesp)Universidade do Porto2014-05-20T14:21:00Z2014-05-20T14:21:00Z2011-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article256-261application/pdfhttp://dx.doi.org/10.1590/S0100-40422011000200016Química Nova. Sociedade Brasileira de Química, v. 34, n. 2, p. 256-261, 2011.0100-4042http://hdl.handle.net/11449/2629110.1590/S0100-40422011000200016S0100-40422011000200016S0100-40422011000200016.pdf319212509836112159789085918535240000-0003-0197-7369SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengQuímica Nova0.6460,255info:eu-repo/semantics/openAccessRufino, José Luiz [UNESP]Pezza, Helena Redigolo [UNESP]Pezza, Leonardo [UNESP]Pinto, Paula C. A. G.Saraiva, M. Lúcia M. F. S.Lima, José L. F. C.2025-05-28T05:23:52Zoai:repositorio.unesp.br:11449/26291Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-05-28T05:23:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulations
title Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulations
spellingShingle Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulations
Rufino, José Luiz [UNESP]
sequential injection analysis
spectrophotometry
pharmaceutical formulations
title_short Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulations
title_full Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulations
title_fullStr Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulations
title_full_unstemmed Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulations
title_sort Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulations
dc.creator.none.fl_str_mv Rufino, José Luiz [UNESP]
Pezza, Helena Redigolo [UNESP]
Pezza, Leonardo [UNESP]
Pinto, Paula C. A. G.
Saraiva, M. Lúcia M. F. S.
Lima, José L. F. C.
author Rufino, José Luiz [UNESP]
author_facet Rufino, José Luiz [UNESP]
Pezza, Helena Redigolo [UNESP]
Pezza, Leonardo [UNESP]
Pinto, Paula C. A. G.
Saraiva, M. Lúcia M. F. S.
Lima, José L. F. C.
author_role author
author2 Pezza, Helena Redigolo [UNESP]
Pezza, Leonardo [UNESP]
Pinto, Paula C. A. G.
Saraiva, M. Lúcia M. F. S.
Lima, José L. F. C.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade do Porto
dc.subject.por.fl_str_mv sequential injection analysis
spectrophotometry
pharmaceutical formulations
topic sequential injection analysis
spectrophotometry
pharmaceutical formulations
description This work proposes a sequential injection analysis (SIA) system for the spectrophotometric determination of norfloxacin (NOR) and ciprofloxacin (CIP) in pharmaceutical formulations. The methodology was based on the reaction of these drugs with p-(dimethylamino)cinnamaldehyde in micellar medium, producing orange colored products (λmax = 495 nm). Beer´s law was obeyed in the concentration range from 2.75x10-5 to 3.44x10-4 mol L-1 and 3.26x10-5 to 3.54x10-4 mol L-1 for NOR and CIP, respectively and sampling rate was 25 h-1. Commercial samples were analyzed and results obtained through the proposed method were in good agreement with those obtained using the reference procedure for a 95% confidence level.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
2014-05-20T14:21:00Z
2014-05-20T14:21:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-40422011000200016
Química Nova. Sociedade Brasileira de Química, v. 34, n. 2, p. 256-261, 2011.
0100-4042
http://hdl.handle.net/11449/26291
10.1590/S0100-40422011000200016
S0100-40422011000200016
S0100-40422011000200016.pdf
3192125098361121
5978908591853524
0000-0003-0197-7369
url http://dx.doi.org/10.1590/S0100-40422011000200016
http://hdl.handle.net/11449/26291
identifier_str_mv Química Nova. Sociedade Brasileira de Química, v. 34, n. 2, p. 256-261, 2011.
0100-4042
10.1590/S0100-40422011000200016
S0100-40422011000200016
S0100-40422011000200016.pdf
3192125098361121
5978908591853524
0000-0003-0197-7369
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Química Nova
0.646
0,255
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 256-261
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1853671694005174272
score 15,301603

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