Síntese de macrociclos derivados de D-glicosamina.
The macrocycles form an important class of compounds that, by having various biological activities and many drugs available, are targets of intense research. The challenge of synthesizing macrocycles via short and efficient synthetic routes, with yields that made possible the assessment of organic c...
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| Tipo de recurso: | tesis de maestría |
| Estado: | Versión publicada |
| Fecha de publicación: | 2009 |
| País: | Brasil |
| Institución: | Universidade Federal de Minas Gerais (UFMG) |
| Repositorio: | Repositório Institucional da UFMG |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.ufmg.br:1843/FARD-82KM3T |
| Acceso en línea: | http://hdl.handle.net/1843/FARD-82KM3T |
| Access Level: | acceso abierto |
| Palabra clave: | macrociclos ciclização radicalar Carboidratos glicosamina Síntese orgânica Química farmacêutica Química orgânica Farmácia |
| Sumario: | The macrocycles form an important class of compounds that, by having various biological activities and many drugs available, are targets of intense research. The challenge of synthesizing macrocycles via short and efficient synthetic routes, with yields that made possible the assessment of organic compounds, were the goals of this work.Two glycosides were synthesized from D-glucosamine by four steps. These glycosides were submitted to Bu3SnH/AIBN-mediated radical carbocyclization reactions to furnish three macrocycles and two products of aromatic radical substitution. |
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