Rhabdomyolysis and acute renal failure after strenuous exercise and alcohol abuse: case report and literature review
CONTEXT: Rhabdomyolysis is a severe and life- threatening condition in which skeletal muscle is damaged. Acute renal failure due to rhab- domyolysis has been widely described and its main pathophysiological mechanisms are renal vasoconstriction, intraluminal cast formation and direct myoglobin toxic...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2005 |
| País: | Brasil |
| Institución: | Associação Paulista de Medicina |
| Repositorio: | São Paulo medical journal (Online) |
| Idioma: | inglés |
| OAI Identifier: | oai:ojs.diagnosticoetratamento.emnuvens.com.br:article/2302 |
| Acceso en línea: | https://periodicosapm.emnuvens.com.br/spmj/article/view/2302 |
| Access Level: | acceso abierto |
| Palabra clave: | Rabdomiólise Insuficiência renal aguda Síndromes de compartimento Exercícios Intoxicação por álcool Rhabdomyolysis Acute kidney failure Compartment syndrome Exercise Alcoholic intoxication |
| Sumario: | CONTEXT: Rhabdomyolysis is a severe and life- threatening condition in which skeletal muscle is damaged. Acute renal failure due to rhab- domyolysis has been widely described and its main pathophysiological mechanisms are renal vasoconstriction, intraluminal cast formation and direct myoglobin toxicity. OBJECTIVE: To report on a case of acute renal failure (ARF) induced by rhabdomyolysis due to strenuous exercise and alcohol abuse and to de- scribe the pathophysiology of this type of ARF. CASE REPORT: A 39-year-old man arrived at the hospital emergency service with swollen legs and lower extremity compartment syndrome. He was oliguric and had serum creatinine and urea levels of 8.1 mg/dl and 195 mg/dl, respectively. The diagnosis of rhabdomyolysis was made through clinical and laboratory findings (creatine kinase activity of 26320 IU/l). The initial treatment consisted of fluid replacement and forced diuresis. The specific treatment for compartment syndrome, such as fasciotomy, was avoided in order to prevent infection. Partial recovery of re- nal function was recorded, after ten hemodialysis sessions. Complete recovery was observed after two months of follow-up. |
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