Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection

Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.

Detalhes bibliográficos
Autores: Silva, F. H. Guedes da, Batista, D. G. J., Silva, C. F. da, Meuser, M. B., Silva, M. R. Simões, Araújo, J. S. de, Ferreira, C. G., Moreira, O. C., Britto, C., Lepesheva, G. I., Soeiro, Maria de Nazaré C.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2015
País:Brasil
Recursos:Fundação Oswaldo Cruz (FIOCRUZ)
Repositório:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglês
OAI Identifier:oai:arca.fiocruz.br:icict/14816
Acesso em linha:https://arca.fiocruz.br/handle/icict/14816
Access Level:Acceso aberto
Palavra-chave:Trypanosoma cruzi
Doença de Chagas
Tratamento
Chagas Disease
Benznidazole
Treatment
03 Saúde e Bem-Estar
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oai_identifier_str oai:arca.fiocruz.br:icict/14816
network_acronym_str BR
network_name_str Brasil
repository_id_str
dc.title.none.fl_str_mv Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection
title Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection
spellingShingle Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection
Silva, F. H. Guedes da
Trypanosoma cruzi
Doença de Chagas
Tratamento
Trypanosoma cruzi
Chagas Disease
Benznidazole
Treatment
03 Saúde e Bem-Estar
title_short Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection
title_full Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection
title_fullStr Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection
title_full_unstemmed Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection
title_sort Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection
dc.creator.none.fl_str_mv Silva, F. H. Guedes da
Batista, D. G. J.
Silva, C. F. da
Meuser, M. B.
Silva, M. R. Simões
Araújo, J. S. de
Ferreira, C. G.
Moreira, O. C.
Britto, C.
Lepesheva, G. I.
Soeiro, Maria de Nazaré C.
author Silva, F. H. Guedes da
author_facet Silva, F. H. Guedes da
Batista, D. G. J.
Silva, C. F. da
Meuser, M. B.
Silva, M. R. Simões
Araújo, J. S. de
Ferreira, C. G.
Moreira, O. C.
Britto, C.
Lepesheva, G. I.
Soeiro, Maria de Nazaré C.
author_role author
author2 Batista, D. G. J.
Silva, C. F. da
Meuser, M. B.
Silva, M. R. Simões
Araújo, J. S. de
Ferreira, C. G.
Moreira, O. C.
Britto, C.
Lepesheva, G. I.
Soeiro, Maria de Nazaré C.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.other.none.fl_str_mv Trypanosoma cruzi
Doença de Chagas
Tratamento
topic Trypanosoma cruzi
Doença de Chagas
Tratamento
Trypanosoma cruzi
Chagas Disease
Benznidazole
Treatment
03 Saúde e Bem-Estar
dc.subject.en.none.fl_str_mv Trypanosoma cruzi
Chagas Disease
Benznidazole
Treatment
dc.subject.ods.none.fl_str_mv 03 Saúde e Bem-Estar
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-07-08T18:49:12Z
dc.date.available.fl_str_mv 2016-07-07T14:19:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, F. H. Guedes da; et al. Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection. Antimicrob Agents Chemother., v.59, n.12, p.7564–7570, Dec. 2015.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/14816
dc.identifier.issn.none.fl_str_mv 0066-4804
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.01294-15
dc.identifier.eissn.none.fl_str_mv 1098-6596
identifier_str_mv SILVA, F. H. Guedes da; et al. Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection. Antimicrob Agents Chemother., v.59, n.12, p.7564–7570, Dec. 2015.
0066-4804
10.1128/AAC.01294-15
1098-6596
url https://arca.fiocruz.br/handle/icict/14816
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2016-07-08T18:49:12Z2016-07-07T14:19:53Z2015SILVA, F. H. Guedes da; et al. Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection. Antimicrob Agents Chemother., v.59, n.12, p.7564–7570, Dec. 2015.0066-4804https://arca.fiocruz.br/handle/icict/1481610.1128/AAC.01294-151098-6596engAmerican Society for MicrobiologyTrypanosoma cruziDoença de ChagasTratamentoTrypanosoma cruziChagas DiseaseBenznidazoleTreatment03 Saúde e Bem-EstarDifferent Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Vanderbilt University. Institute for Global Health. Department of Biochemistry. Nashville, Tennessee, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.The lack of translation between preclinical assays and clinical trials for novel therapies for Chagas disease (CD) indicates a need for more feasible and standardized protocols and experimental models. Here, we investigated the effects of treatment with benznidazole (Bz) and with the potent experimental T. cruzi CYP51 inhibitor VNI in mouse models of Chagas disease by using different animal genders and parasite strains and employing distinct types of therapeutic schemes. Our findings confirm that female mice are less vulnerable to the infection than males, show that male models are less susceptible to treatment with both Bz and VNI, and thus suggest that male models are much more suitable for selection of the most promising antichagasic agents. Additionally, we have found that preventive protocols (compound given at 1 dpi) result in higher treatment success rates, which also should be avoided during advanced steps of in vivo trials of novel anti-T. cruzi drug candidates. Another consideration is the relevance of immunosuppression methods in order to verify the therapeutic profile of novel compounds, besides the usefulness of molecular diagnostic tools (quantitative PCR) to ascertain compound efficacy in experimental animals. Our study aims to contribute to the development of more reliable methods and decision gates for in vivo assays of novel antiparasitic compounds in order to move them from preclinical to clinical trials for CD.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZSilva, F. H. Guedes daBatista, D. G. J.Silva, C. F. daMeuser, M. B.Silva, M. R. SimõesAraújo, J. S. deFerreira, C. G.Moreira, O. C.Britto, C.Lepesheva, G. 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