Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic rats
Aims: The effect of exercise training (ET) on vascular responsiveness in diabetes mellitus has been largely well studied. However, limited studies have investigated the effects of ET on functional responses of the corpus cavernosum (CC) in diabetic animals. Therefore, the aim of this study was to in...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2011 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/72300 |
| Acceso en línea: | http://dx.doi.org/10.1016/j.lfs.2010.11.018 http://hdl.handle.net/11449/72300 |
| Access Level: | acceso abierto |
| Palabra clave: | Corpus cavernosum Diabetes Physical training Superoxide dismutase 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide 4 amino 5 cyclopropyl 2 [1 (2 fluorobenzyl) 1h pyrazolo[3,4 b]pyridin 3 yl]pyrimidine acetylcholine nitric oxide nitroprusside sodium phenylephrine superoxide dismutase animal experiment animal model animal tissue blood vessel reactivity controlled study corpus cavernosum diabetes mellitus electrostimulation erectile dysfunction exercise male nitrergic nerve nonhuman rat smooth muscle relaxation streptozocin diabetes vascular endothelium Animals Cells, Cultured Diabetes Mellitus, Experimental Erectile Dysfunction Male Muscle Contraction Muscle, Smooth Penile Erection Physical Conditioning, Animal Rats Animalia Rattus |
| Sumario: | Aims: The effect of exercise training (ET) on vascular responsiveness in diabetes mellitus has been largely well studied. However, limited studies have investigated the effects of ET on functional responses of the corpus cavernosum (CC) in diabetic animals. Therefore, the aim of this study was to investigate whether prior ET prevents the impairment of erectile function in streptozotocin-induced diabetic rats. Main methods: Rats were exercised for four weeks prior to the induction of diabetes, and then again for another 4 weeks thereafter. Concentration-response curves to acetylcholine, sodium nitroprusside, Y-27632, BAY 412272 and phenylephrine (PE) were obtained in CC. The excitatory and inhibitory effects of electrical-field stimulation were also evaluated. Key findings: Plasma SOD levels were markedly decreased in the sedentary diabetic group (D-SD) as compared to control sedentary animals (C-SD), approximately 53% (P < 0.05) and this reduction was restored in trained diabetic animals. Physical training restored the impairment of endothelium-dependent and -independent relaxation responses seen in the D-SD group. The potency values for Y-27632 in the CC were significantly reduced in the D-SD group, which was reversed by physical training. The impairment of electrical-field stimulation (EFS)-induced relaxation seen in the D-SD group was restored by physical training. On the other hand, both EFS-induced contractions and concentration-response curves to PE in cavernosal strips were not modified by either diabetes or physical training. Significance: Practice of regular physical exercise may be an important approach in preventing erectile dysfunction associated with diabetes mellitus by re-establishment of the balance between NO production and its inactivation. © 2010 Elsevier Inc. All rights reserved. |
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