Hiperplasia de células neuroendócrinas pulmonares difusas com obstrução ao fluxo aéreo

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia with airflow obstruction is a rare form of lung injury. All of the reported cases have been diagnosed by surgical lung biopsy. Only three of the reported cases presented with diffuse interstitial lung opacities on HRCT scans. We report thr...

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Detalles Bibliográficos
Autores: Coletta, Ester Nei Aparecida Martins [UNIFESP], Voss, Larissa Rêgo, Lima, Mariana Silva [UNIFESP], Ota-Arakaki, Jaquelina Sonoe [UNIFESP], Câmara, Juvêncio, D'Andretta Neto, Carlos, Pereira, Carlos Alberto de Castro [UNIFESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:Brasil
Institución:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:portugués
OAI Identifier:oai:repositorio.unifesp.br:11600/5007
Acceso en línea:http://dx.doi.org/10.1590/S1806-37132009000500017
http://repositorio.unifesp.br/handle/11600/5007
Access Level:acceso abierto
Palabra clave:Neuroendocrine cells
Carcinoid tumor
Bronchiolitis obliterans
Células neuroendócrinas
Tumor carcinoide
Bronquiolite obliterante
Descripción
Sumario:Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia with airflow obstruction is a rare form of lung injury. All of the reported cases have been diagnosed by surgical lung biopsy. Only three of the reported cases presented with diffuse interstitial lung opacities on HRCT scans. We report three additional cases of this entity. All of the patients were female and presented with mild-to-moderate airflow obstruction. In the first case, transbronchial biopsy and imaging data were sufficient to make the diagnosis. Although the HRCT scans of all three cases revealed a mosaic pattern, that of the third patient also revealed diffuse interstitial infiltrate. In extremely rare cases, HRCT findings can simulate those seen in other interstitial lung diseases.