1.39 - Intestinal Dysbiosis in Autoimmune Diseases
Evidence from animal models and humans suggests the role of intestinal dysbiosis in autoimmune disease development. Dysbiosis is associated with decreased microbiota function and diversity, increased intestinal permeability and pathobionts, and deregulated immune response. The proposed mechanisms to...
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| Tipo de recurso: | capítulo de libro |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/247117 |
| Acceso en línea: | http://dx.doi.org/10.1016/B978-0-12-819265-8.00038-3 http://hdl.handle.net/11449/247117 |
| Access Level: | acceso abierto |
| Palabra clave: | Autoimmunity Dysbiosis Graves' disease Hashimoto thyroiditis Inflammation Microbiota Probiotics Rheumatoid arthritis Sjögren syndrome Systemic lupus erythematosus Systemic sclerosis Type 1 diabetes |
| Sumario: | Evidence from animal models and humans suggests the role of intestinal dysbiosis in autoimmune disease development. Dysbiosis is associated with decreased microbiota function and diversity, increased intestinal permeability and pathobionts, and deregulated immune response. The proposed mechanisms to connect dysbiosis with autoimmunity include molecular mimicry, bystander T-cell activation, epitope spreading, post-translational modification of luminal proteins, and amplification by inflammatory cytokines. Probiotic bacteria favor the balance and maintenance of a healthy microbiota and epithelial barrier and directly impact systemic immunity, supporting their use in immune-mediated diseases. This article describes studies concerning dysbiosis and probiotics in autoimmune diseases. |
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