Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats

The purpose of this study was to evaluate the effects of simvastatin, by oral or subcutaneous administration, on tibial defects regeneration and blood cholesterol level in rats. A surgical defect was made on the right tibia of 40 male animals assigned to 4 groups (n=10), based on two routes of admin...

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Detalles Bibliográficos
Autores: Anbinder, Ana Lia, Junqueira, Juliana Campos [UNESP], Mancini, Maria Nadir G., Balducci, Ivan [UNESP], Rocha, Rosilene Fernandes da, Carvalho, Yasmin Rodarte
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2006
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/69295
Acceso en línea:http://dx.doi.org/10.1590/S0103-64402006000400001
http://hdl.handle.net/11449/69295
Access Level:acceso abierto
Palabra clave:Bone regeneration
Cholesterol
Rats
Simvastatin
cholesterol
chromogenic substrate
diagnostic agent
hypocholesterolemic agent
simvastatin
animal
blood
bone development
bone disease
bone regeneration
bone remodeling
drug effect
male
oral drug administration
osteoblast
osteocyte
pathology
periosteum
rat
subcutaneous drug administration
tibia
time
Wistar rat
Administration, Oral
Animals
Anticholesteremic Agents
Bone Diseases
Bone Regeneration
Bone Remodeling
Chromogenic Compounds
Injections, Subcutaneous
Male
Osteoblasts
Osteocytes
Osteogenesis
Periosteum
Rats, Wistar
Tibia
Time Factors
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spelling Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in ratsBone regenerationCholesterolRatsSimvastatincholesterolchromogenic substratediagnostic agenthypocholesterolemic agentsimvastatinanimalbloodbone developmentbone diseasebone regenerationbone remodelingdrug effectmaleoral drug administrationosteoblastosteocytepathologyperiosteumratsubcutaneous drug administrationtibiatimeWistar ratAdministration, OralAnimalsAnticholesteremic AgentsBone DiseasesBone RegenerationBone RemodelingChromogenic CompoundsInjections, SubcutaneousMaleOsteoblastsOsteocytesOsteogenesisPeriosteumRats, WistarTibiaTime FactorsThe purpose of this study was to evaluate the effects of simvastatin, by oral or subcutaneous administration, on tibial defects regeneration and blood cholesterol level in rats. A surgical defect was made on the right tibia of 40 male animals assigned to 4 groups (n=10), based on two routes of administration and on the use or not of simvastatin: subcutaneous injection of simvastatin (7 mg/kg) (group AT) or only the vehicle of drug suspension (group AC), above the defect area, for 5 days; and 20 mg/kg of simvastatin macerated on water (group BT) or only water (group BC), orally, daily, during the whole observation period. The animals were sacrificed after 15 or 30 days, when blood samples were analyzed to check plasma cholesterol levels. Tibiae were removed and, after decalcification and routine laboratorial processing, histological and histomorphometrical analyses were carried out. ANOVA was used for statistical analysis at 5% signficance level. The histological and histomorphometrical analyses showed significant differences only between the experimental periods (p<0.05). Animals sacrificed after 30 days showed better bone repair (p<0.05). There was no statistically significant difference (p>0.05) for blood cholesterol levels between the groups. In conclusion, simvastatin administration either orally or subcutaneously did not improve bone repair of experimental tibial defects and did not alter blood cholesterol levels in rats.Department of Dentistry University of Taubaté, Taubaté, SPDepartment of Biosciences and Oral Diagnosis, São José dos Campos, SPDepartment of Social Dentistry and Pediatric Clinics School of Dentistry of São José dos Campos São Paulo State University, São José dos Campos, SPDepartment of Social Dentistry and Pediatric Clinics School of Dentistry of São José dos Campos São Paulo State University, São José dos Campos, SPUniversidade de Taubaté (UNITAU)Universidade Estadual Paulista (Unesp)2014-05-27T11:22:04Z2014-05-27T11:22:04Z2006-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article267-273application/pdfhttp://dx.doi.org/10.1590/S0103-64402006000400001Brazilian Dental Journal, v. 17, n. 4, p. 267-273, 2006.0103-64401806-4760http://hdl.handle.net/11449/6929510.1590/S0103-64402006000400001S0103-644020060004000012-s2.0-34047178532S0103-64402006000400001.pdf60979679430082730322020541055900019036523451602769673691197921510000-0003-3930-4274Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Dental Journal0,476info:eu-repo/semantics/openAccessAnbinder, Ana LiaJunqueira, Juliana Campos [UNESP]Mancini, Maria Nadir G.Balducci, Ivan [UNESP]Rocha, Rosilene Fernandes daCarvalho, Yasmin Rodarte2024-11-18T19:56:45Zoai:repositorio.unesp.br:11449/69295Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-11-18T19:56:45Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats
title Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats
spellingShingle Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats
Anbinder, Ana Lia
Bone regeneration
Cholesterol
Rats
Simvastatin
cholesterol
chromogenic substrate
diagnostic agent
hypocholesterolemic agent
simvastatin
animal
blood
bone development
bone disease
bone regeneration
bone remodeling
drug effect
male
oral drug administration
osteoblast
osteocyte
pathology
periosteum
rat
subcutaneous drug administration
tibia
time
Wistar rat
Administration, Oral
Animals
Anticholesteremic Agents
Bone Diseases
Bone Regeneration
Bone Remodeling
Chromogenic Compounds
Injections, Subcutaneous
Male
Osteoblasts
Osteocytes
Osteogenesis
Periosteum
Rats, Wistar
Tibia
Time Factors
title_short Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats
title_full Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats
title_fullStr Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats
title_full_unstemmed Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats
title_sort Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats
dc.creator.none.fl_str_mv Anbinder, Ana Lia
Junqueira, Juliana Campos [UNESP]
Mancini, Maria Nadir G.
Balducci, Ivan [UNESP]
Rocha, Rosilene Fernandes da
Carvalho, Yasmin Rodarte
author Anbinder, Ana Lia
author_facet Anbinder, Ana Lia
Junqueira, Juliana Campos [UNESP]
Mancini, Maria Nadir G.
Balducci, Ivan [UNESP]
Rocha, Rosilene Fernandes da
Carvalho, Yasmin Rodarte
author_role author
author2 Junqueira, Juliana Campos [UNESP]
Mancini, Maria Nadir G.
Balducci, Ivan [UNESP]
Rocha, Rosilene Fernandes da
Carvalho, Yasmin Rodarte
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Taubaté (UNITAU)
Universidade Estadual Paulista (Unesp)
dc.subject.por.fl_str_mv Bone regeneration
Cholesterol
Rats
Simvastatin
cholesterol
chromogenic substrate
diagnostic agent
hypocholesterolemic agent
simvastatin
animal
blood
bone development
bone disease
bone regeneration
bone remodeling
drug effect
male
oral drug administration
osteoblast
osteocyte
pathology
periosteum
rat
subcutaneous drug administration
tibia
time
Wistar rat
Administration, Oral
Animals
Anticholesteremic Agents
Bone Diseases
Bone Regeneration
Bone Remodeling
Chromogenic Compounds
Injections, Subcutaneous
Male
Osteoblasts
Osteocytes
Osteogenesis
Periosteum
Rats, Wistar
Tibia
Time Factors
topic Bone regeneration
Cholesterol
Rats
Simvastatin
cholesterol
chromogenic substrate
diagnostic agent
hypocholesterolemic agent
simvastatin
animal
blood
bone development
bone disease
bone regeneration
bone remodeling
drug effect
male
oral drug administration
osteoblast
osteocyte
pathology
periosteum
rat
subcutaneous drug administration
tibia
time
Wistar rat
Administration, Oral
Animals
Anticholesteremic Agents
Bone Diseases
Bone Regeneration
Bone Remodeling
Chromogenic Compounds
Injections, Subcutaneous
Male
Osteoblasts
Osteocytes
Osteogenesis
Periosteum
Rats, Wistar
Tibia
Time Factors
description The purpose of this study was to evaluate the effects of simvastatin, by oral or subcutaneous administration, on tibial defects regeneration and blood cholesterol level in rats. A surgical defect was made on the right tibia of 40 male animals assigned to 4 groups (n=10), based on two routes of administration and on the use or not of simvastatin: subcutaneous injection of simvastatin (7 mg/kg) (group AT) or only the vehicle of drug suspension (group AC), above the defect area, for 5 days; and 20 mg/kg of simvastatin macerated on water (group BT) or only water (group BC), orally, daily, during the whole observation period. The animals were sacrificed after 15 or 30 days, when blood samples were analyzed to check plasma cholesterol levels. Tibiae were removed and, after decalcification and routine laboratorial processing, histological and histomorphometrical analyses were carried out. ANOVA was used for statistical analysis at 5% signficance level. The histological and histomorphometrical analyses showed significant differences only between the experimental periods (p<0.05). Animals sacrificed after 30 days showed better bone repair (p<0.05). There was no statistically significant difference (p>0.05) for blood cholesterol levels between the groups. In conclusion, simvastatin administration either orally or subcutaneously did not improve bone repair of experimental tibial defects and did not alter blood cholesterol levels in rats.
publishDate 2006
dc.date.none.fl_str_mv 2006-12-01
2014-05-27T11:22:04Z
2014-05-27T11:22:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0103-64402006000400001
Brazilian Dental Journal, v. 17, n. 4, p. 267-273, 2006.
0103-6440
1806-4760
http://hdl.handle.net/11449/69295
10.1590/S0103-64402006000400001
S0103-64402006000400001
2-s2.0-34047178532
S0103-64402006000400001.pdf
6097967943008273
0322020541055900
0190365234516027
6967369119792151
0000-0003-3930-4274
url http://dx.doi.org/10.1590/S0103-64402006000400001
http://hdl.handle.net/11449/69295
identifier_str_mv Brazilian Dental Journal, v. 17, n. 4, p. 267-273, 2006.
0103-6440
1806-4760
10.1590/S0103-64402006000400001
S0103-64402006000400001
2-s2.0-34047178532
S0103-64402006000400001.pdf
6097967943008273
0322020541055900
0190365234516027
6967369119792151
0000-0003-3930-4274
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Dental Journal
0,476
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 267-273
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1853672375222009856
score 15,301603

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