Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression

Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) (JCB0047/2013 to DP and 5760/2015 to VMB); The Research Foundation Flanders-FWO (G0D6817N to JVW). FC was supported by a grant from the National Institutes of Health (NIH) AI119030. NL received funding from CAPES – Coordenação de Aperfeiçoame...

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Detalles Bibliográficos
Autores: Luz, Nívea Farias, Cunha, Antonio Ricardo Khouri, Van Weyenbergh, Johan, Zanette, Dalila Lucíola, Fiuza, Paloma Peixoto dos Santos, Noronha, Almerio, Barral, Aldina Maria Prado, Boaventura, Viviane Sampaio, Prates, Deboraci Brito, Chan, Francis Ka-Ming, Andrade, Bruno de Bezerril, Borges, Valeria de Matos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:Brasil
Institución:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/30423
Acceso en línea:https://arca.fiocruz.br/handle/icict/30423
Access Level:acceso abierto
Palabra clave:RIPK3
MLKL
Macrófago
Necroptose
Leishmania braziliensis
Macrophage
Necroptosis
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oai_identifier_str oai:arca.fiocruz.br:icict/30423
network_acronym_str BR
network_name_str Brasil
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dc.title.none.fl_str_mv Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
title Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
spellingShingle Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
Luz, Nívea Farias
RIPK3
MLKL
Macrófago
Necroptose
Leishmania braziliensis
RIPK3
MLKL
Macrophage
Necroptosis
Leishmania braziliensis
title_short Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
title_full Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
title_fullStr Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
title_full_unstemmed Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
title_sort Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
dc.creator.none.fl_str_mv Luz, Nívea Farias
Cunha, Antonio Ricardo Khouri
Van Weyenbergh, Johan
Zanette, Dalila Lucíola
Fiuza, Paloma Peixoto dos Santos
Noronha, Almerio
Barral, Aldina Maria Prado
Boaventura, Viviane Sampaio
Prates, Deboraci Brito
Chan, Francis Ka-Ming
Andrade, Bruno de Bezerril
Borges, Valeria de Matos
author Luz, Nívea Farias
author_facet Luz, Nívea Farias
Cunha, Antonio Ricardo Khouri
Van Weyenbergh, Johan
Zanette, Dalila Lucíola
Fiuza, Paloma Peixoto dos Santos
Noronha, Almerio
Barral, Aldina Maria Prado
Boaventura, Viviane Sampaio
Prates, Deboraci Brito
Chan, Francis Ka-Ming
Andrade, Bruno de Bezerril
Borges, Valeria de Matos
author_role author
author2 Cunha, Antonio Ricardo Khouri
Van Weyenbergh, Johan
Zanette, Dalila Lucíola
Fiuza, Paloma Peixoto dos Santos
Noronha, Almerio
Barral, Aldina Maria Prado
Boaventura, Viviane Sampaio
Prates, Deboraci Brito
Chan, Francis Ka-Ming
Andrade, Bruno de Bezerril
Borges, Valeria de Matos
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.other.none.fl_str_mv RIPK3
MLKL
Macrófago
Necroptose
Leishmania braziliensis
topic RIPK3
MLKL
Macrófago
Necroptose
Leishmania braziliensis
RIPK3
MLKL
Macrophage
Necroptosis
Leishmania braziliensis
dc.subject.en.none.fl_str_mv RIPK3
MLKL
Macrophage
Necroptosis
Leishmania braziliensis
description Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) (JCB0047/2013 to DP and 5760/2015 to VMB); The Research Foundation Flanders-FWO (G0D6817N to JVW). FC was supported by a grant from the National Institutes of Health (NIH) AI119030. NL received funding from CAPES – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Grants 88887.142000/2017-00 and 88887.137958/2017-00). VMB and AB are senior investigators of CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico).
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-12-07T16:54:31Z
dc.date.available.fl_str_mv 2018-12-07T16:54:31Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LUZ, Nívea Farias et al. Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression. Frontiers in Microbiology, v. 9, p. 1-6, 2018.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/30423
dc.identifier.issn.none.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2018.02283
identifier_str_mv LUZ, Nívea Farias et al. Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression. Frontiers in Microbiology, v. 9, p. 1-6, 2018.
1664-302X
10.3389/fmicb.2018.02283
url https://arca.fiocruz.br/handle/icict/30423
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2018-12-07T16:54:31Z2018-12-07T16:54:31Z2018LUZ, Nívea Farias et al. Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression. Frontiers in Microbiology, v. 9, p. 1-6, 2018.1664-302Xhttps://arca.fiocruz.br/handle/icict/3042310.3389/fmicb.2018.02283Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) (JCB0047/2013 to DP and 5760/2015 to VMB); The Research Foundation Flanders-FWO (G0D6817N to JVW). FC was supported by a grant from the National Institutes of Health (NIH) AI119030. NL received funding from CAPES – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Grants 88887.142000/2017-00 and 88887.137958/2017-00). VMB and AB are senior investigators of CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Rega Institute for Medical Research. KU Leuven. Department of Microbiology and Immunology. Leuven, Belgium.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biomorfologia. Salvador, BA, Brasil.Duke University Medical Center. Department of Immunology. Durham, NC, United States.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Leishmania braziliensis infection causes skin ulcers, typically found in localized cutaneous leishmaniasis (LCL). This tissue pathology associates with different modalities of cell necrosis, which are subverted by the parasite as a survival strategy. Herein we examined the participation of necroptosis, a specific form of programmed necrosis, in LCL lesions and found reduced RIPK3 and PGAM5 gene expression compared to normal skin. Assays using infected macrophages demonstrated that the parasite deactivates both RIPK3 and MLKL expression and that these molecules are important to control the intracellular L. braziliensis replication. Thus, LCL-related necroptosis may be targeted to control infection and disease immunopathology.engFrontiers MediaRIPK3MLKLMacrófagoNecroptoseLeishmania braziliensisRIPK3MLKLMacrophageNecroptosisLeishmania braziliensisLeishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expressioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLuz, Nívea FariasCunha, Antonio Ricardo KhouriVan Weyenbergh, JohanZanette, Dalila LucíolaFiuza, Paloma Peixoto dos SantosNoronha, AlmerioBarral, Aldina Maria PradoBoaventura, Viviane SampaioPrates, Deboraci BritoChan, Francis Ka-MingAndrade, Bruno de BezerrilBorges, Valeria de MatosLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/3d4bdf47-c95e-4d52-8872-44b45169c9a7/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALLuz NF. 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