M1 muscarinic receptors are necessary for retrieval of remote context fear memory

Several studies have investigated the transition of consolidation of recent memory to remote memory in aversively motivated tasks, such as contextual fear conditioning (CFC) and inhibitory avoidance (IA). However, the mechanisms that serve the retrieval of remote memories, has not yet been fully und...

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Detalles Bibliográficos
Autores: Patricio, Rafael Rodisanski [UNIFESP], Kramer Soares, Juliana Carlota [UNIFESP], Menezes Oliveira, Maria Gabriela [UNIFESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Brasil
Institución:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/55215
Acceso en línea:http://dx.doi.org/10.1016/j.physbeh.2016.12.008
https://repositorio.unifesp.br/handle/11600/55215
Access Level:acceso abierto
Palabra clave:Fear conditioning
Inhibitory avoidance
Memory retrieval
Remote memory
Ml receptor
Acetylcholine
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spelling M1 muscarinic receptors are necessary for retrieval of remote context fear memoryFear conditioningInhibitory avoidanceMemory retrievalRemote memoryMl receptorAcetylcholineSeveral studies have investigated the transition of consolidation of recent memory to remote memory in aversively motivated tasks, such as contextual fear conditioning (CFC) and inhibitory avoidance (IA). However, the mechanisms that serve the retrieval of remote memories, has not yet been fully understood. Some evidences suggest that the central cholinergic system appears be involved in the modulation of these processes. Therefore, the present study aimed to investigate the effects of a pre-test administration of dicyclomine, a high-affinity M1 muscarinic receptor antagonist, on the retrieval of remote memories in fear conditioning and IA tasks. Male Wistar rats were trained, and after 1 or 28 days, the rats received dicyclomine (16 or 32 mg/lcg, intraperitoneally, i.p.) and were tested in CFC, tone fear conditioning (TFC) and IA tasks. At both time intervals, 32 mg/kg dicydomine induced impairment of CFC. In TFC task only the performance of the rats 28 days after training was impaired. The IA task was not affected in any of the studied intervals. These findings suggest a differential contribution of muscarinic receptors on recent and remote memories retrieval revealing a more generalized role in remote memory. (C) 2016 Elsevier Inc. All rights reserved.Univ Fed Sao Paulo, UNIFESP, Dept Psicobiol, Rua Botucatu,862 1 Andar, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, UNIFESP, Dept Psicobiol, Rua Botucatu,862 1 Andar, Sao Paulo, SP, BrazilWeb of ScienceSao Paulo Research Foundation (FAPESP)Research Incentive Fund Association (Associacao Fundo de Incentivo a Pesquisa - AFIP)Coordination for the Improvement of Higher Education Personnel (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES)National Council of Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq)FAPESP: 2009/12871-0Pergamon-Elsevier Science Ltd2020-07-17T14:03:11Z2020-07-17T14:03:11Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion202-207http://dx.doi.org/10.1016/j.physbeh.2016.12.008Physiology & Behavior. Oxford, v. 169, p. 202-207, 2017.10.1016/j.physbeh.2016.12.0080031-9384https://repositorio.unifesp.br/handle/11600/55215WOS:000392774100028ark:/48912/001300002jtn5engPhysiology & BehaviorOxfordinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPPatricio, Rafael Rodisanski [UNIFESP]Kramer Soares, Juliana Carlota [UNIFESP]Menezes Oliveira, Maria Gabriela [UNIFESP]2021-10-05T21:33:39Zoai:repositorio.unifesp.br:11600/55215Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-10-05T21:33:39Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv M1 muscarinic receptors are necessary for retrieval of remote context fear memory
title M1 muscarinic receptors are necessary for retrieval of remote context fear memory
spellingShingle M1 muscarinic receptors are necessary for retrieval of remote context fear memory
Patricio, Rafael Rodisanski [UNIFESP]
Fear conditioning
Inhibitory avoidance
Memory retrieval
Remote memory
Ml receptor
Acetylcholine
title_short M1 muscarinic receptors are necessary for retrieval of remote context fear memory
title_full M1 muscarinic receptors are necessary for retrieval of remote context fear memory
title_fullStr M1 muscarinic receptors are necessary for retrieval of remote context fear memory
title_full_unstemmed M1 muscarinic receptors are necessary for retrieval of remote context fear memory
title_sort M1 muscarinic receptors are necessary for retrieval of remote context fear memory
dc.creator.none.fl_str_mv Patricio, Rafael Rodisanski [UNIFESP]
Kramer Soares, Juliana Carlota [UNIFESP]
Menezes Oliveira, Maria Gabriela [UNIFESP]
author Patricio, Rafael Rodisanski [UNIFESP]
author_facet Patricio, Rafael Rodisanski [UNIFESP]
Kramer Soares, Juliana Carlota [UNIFESP]
Menezes Oliveira, Maria Gabriela [UNIFESP]
author_role author
author2 Kramer Soares, Juliana Carlota [UNIFESP]
Menezes Oliveira, Maria Gabriela [UNIFESP]
author2_role author
author
dc.subject.por.fl_str_mv Fear conditioning
Inhibitory avoidance
Memory retrieval
Remote memory
Ml receptor
Acetylcholine
topic Fear conditioning
Inhibitory avoidance
Memory retrieval
Remote memory
Ml receptor
Acetylcholine
description Several studies have investigated the transition of consolidation of recent memory to remote memory in aversively motivated tasks, such as contextual fear conditioning (CFC) and inhibitory avoidance (IA). However, the mechanisms that serve the retrieval of remote memories, has not yet been fully understood. Some evidences suggest that the central cholinergic system appears be involved in the modulation of these processes. Therefore, the present study aimed to investigate the effects of a pre-test administration of dicyclomine, a high-affinity M1 muscarinic receptor antagonist, on the retrieval of remote memories in fear conditioning and IA tasks. Male Wistar rats were trained, and after 1 or 28 days, the rats received dicyclomine (16 or 32 mg/lcg, intraperitoneally, i.p.) and were tested in CFC, tone fear conditioning (TFC) and IA tasks. At both time intervals, 32 mg/kg dicydomine induced impairment of CFC. In TFC task only the performance of the rats 28 days after training was impaired. The IA task was not affected in any of the studied intervals. These findings suggest a differential contribution of muscarinic receptors on recent and remote memories retrieval revealing a more generalized role in remote memory. (C) 2016 Elsevier Inc. All rights reserved.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-07-17T14:03:11Z
2020-07-17T14:03:11Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.physbeh.2016.12.008
Physiology & Behavior. Oxford, v. 169, p. 202-207, 2017.
10.1016/j.physbeh.2016.12.008
0031-9384
https://repositorio.unifesp.br/handle/11600/55215
WOS:000392774100028
dc.identifier.dark.fl_str_mv ark:/48912/001300002jtn5
url http://dx.doi.org/10.1016/j.physbeh.2016.12.008
https://repositorio.unifesp.br/handle/11600/55215
identifier_str_mv Physiology & Behavior. Oxford, v. 169, p. 202-207, 2017.
10.1016/j.physbeh.2016.12.008
0031-9384
WOS:000392774100028
ark:/48912/001300002jtn5
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Physiology & Behavior
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 202-207
dc.coverage.none.fl_str_mv Oxford
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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score 15.300719

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