As bases neurobiológicas do transtorno bipolar
In this article, the authors review relevant aspects related to the neurobiological basis of bipolar disorder. This illness has been associated with complex biochemical and molecular changes in brain circuits linked to neurotransmission and intracellular signal transduction pathways, and changes on...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2005 |
| País: | Brasil |
| Institución: | Universidade Federal de São Paulo (UNIFESP) |
| Repositorio: | Repositório Institucional da UNIFESP |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.unifesp.br:11600/2367 |
| Acceso en línea: | http://dx.doi.org/10.1590/S0101-60832005000700005 http://repositorio.unifesp.br/handle/11600/2367 |
| Access Level: | acceso abierto |
| Palabra clave: | Bipolar disorder mania depression neurobiology neuroimaging molecular biology Transtorno bipolar depressão neurobiologia neuroimagem biologia molecular |
| Sumario: | In this article, the authors review relevant aspects related to the neurobiological basis of bipolar disorder. This illness has been associated with complex biochemical and molecular changes in brain circuits linked to neurotransmission and intracellular signal transduction pathways, and changes on neurons and glia have been proposed to be directly associated with clinical presentation of mania and depression. In the same context, dysfunctions on brain homeostasis and energy metabolism have been associated with alterations on circadian rythms, behavior and mood in human and animal models of bipolarity. In the recent years, advances on techniques of neuroimaging, molecular biology and genetics has provided new insights about the biology of bipolarity. The authors emphasize that bipolar disorder has been shown to be directly associated with dysfunctions on neural adaptative mechanisms, promoting neural stress. The resulted stress, even that do not lead to cell death, may limit the neuroplasticity and neurotrophism in neurons and glia, which in turn may facilitate the arousal of this pervasive illness. |
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