β-Ta2O5 thin film for implant surface modification triggers superior anti-corrosion performance and cytocompatibility of titanium
In this study, β-tantalum oxide (β-Ta2O5) thin film was synthesized via magnetron sputtering to improve the surface properties, cytocompatibility and electrochemical stability of titanium. X-ray diffraction analysis confirmed a crystalline orthorhombic phase of Ta2O5 film on the β-Ta2O5 experimental...
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/198732 |
| Acceso en línea: | http://dx.doi.org/10.1016/j.apsusc.2020.146326 http://hdl.handle.net/11449/198732 |
| Access Level: | acceso abierto |
| Palabra clave: | Biomaterials Corrosion Dental implants Magnetron sputtering Protein adsorption Tantalum oxide |
| id |
BR_e7bc028cffdca4f3861ff0b95b101dfe |
|---|---|
| oai_identifier_str |
oai:repositorio.unesp.br:11449/198732 |
| network_acronym_str |
BR |
| network_name_str |
Brasil |
| repository_id_str |
|
| spelling |
β-Ta2O5 thin film for implant surface modification triggers superior anti-corrosion performance and cytocompatibility of titaniumBiomaterialsCorrosionDental implantsMagnetron sputteringProtein adsorptionTantalum oxideIn this study, β-tantalum oxide (β-Ta2O5) thin film was synthesized via magnetron sputtering to improve the surface properties, cytocompatibility and electrochemical stability of titanium. X-ray diffraction analysis confirmed a crystalline orthorhombic phase of Ta2O5 film on the β-Ta2O5 experimental surface. A granular structure with a complex and hierarchical nature was demonstrated by atomic force microscopy. Ta2O5-treated surfaces exhibited greater roughness and hydrophilicity compared with untreated titanium discs (control). Enhanced electrochemical stability in simulated body fluid (pH 7.4) was noted for Ta2O5-treated surfaces wherein higher values of charge transfer resistance, nobler corrosion potential, and lower capacitance, corrosion current density, and corrosion rate values were observed vs untreated control. Real-time monitoring of albumin and fibrinogen proteins adsorption by an electrochemical quartz crystal microbalance disclosed similar protein interactions for control and Ta2O5-treated discs, with higher fibrinogen adsorption rates for Ta2O5-treated surfaces. Cell culture assays (MC3T3-E1 cells) demonstrated that Ta2O5-treated discs featured greater in vitro mineral nodule formation, normal cell morphology and spreading, and increased mRNA levels of runt-related transcription factor 2 (Runx-2), osteocalcin (Ocn), and collagen-1 (Col-1). Therefore, it can be concluded that β-Ta2O5 thin films may be considered a promising strategy to trigger superior long-term stability and biological properties of titanium implants.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)W. M. Keck FoundationFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Materials Research Science and Engineering Center, Harvard UniversityUniversity of Campinas (UNICAMP) Piracicaba Dental School Department of Prosthodontics and Periodontics, Av. Limeira, 901Institute of Biomaterials Tribocorrosion and Nanomedicine (IBTN)São Paulo State University (UNESP) School of Sciences Department of Physics, Av. Eng. Luís Edmundo C. Coube, 14-01University of Campinas (UNICAMP) Piracicaba Dental School Department of Physiological Science, Av. Limeira, 901University of Illinois at Chicago College of Dentistry Department of Restorative Dentistry, 801 S. PaulinaDepartment of Materials Science and Engineering Northwestern UniversityNUANCE Center Northwestern UniversitySão Paulo State University (UNESP) School of Sciences Department of Physics, Av. Eng. Luís Edmundo C. Coube, 14-01FAPESP: 2016/07269-3FAPESP: 2016/11470-6FAPESP: 2017/18916-2Materials Research Science and Engineering Center, Harvard University: NSF DMR-1720139Universidade Estadual de Campinas (UNICAMP)Tribocorrosion and Nanomedicine (IBTN)Universidade Estadual Paulista (Unesp)College of DentistryNorthwestern University2020-12-12T01:20:36Z2020-12-12T01:20:36Z2020-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.apsusc.2020.146326Applied Surface Science, v. 520.0169-4332http://hdl.handle.net/11449/19873210.1016/j.apsusc.2020.1463262-s2.0-85083268587Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengApplied Surface Scienceinfo:eu-repo/semantics/openAccessBeline, Thamarade Almeida, Amanda B.Azevedo Neto, Nilton F. [UNESP]Matos, Adaias O.Ricomini-Filho, Antônio P.Sukotjo, CortinoSmeets, Paul J.M.da Silva, José H.D. [UNESP]Nociti, Francisco H.Barão, Valentim A.R.2025-06-24T05:24:39Zoai:repositorio.unesp.br:11449/198732Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-06-24T05:24:39Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
β-Ta2O5 thin film for implant surface modification triggers superior anti-corrosion performance and cytocompatibility of titanium |
| title |
β-Ta2O5 thin film for implant surface modification triggers superior anti-corrosion performance and cytocompatibility of titanium |
| spellingShingle |
β-Ta2O5 thin film for implant surface modification triggers superior anti-corrosion performance and cytocompatibility of titanium Beline, Thamara Biomaterials Corrosion Dental implants Magnetron sputtering Protein adsorption Tantalum oxide |
| title_short |
β-Ta2O5 thin film for implant surface modification triggers superior anti-corrosion performance and cytocompatibility of titanium |
| title_full |
β-Ta2O5 thin film for implant surface modification triggers superior anti-corrosion performance and cytocompatibility of titanium |
| title_fullStr |
β-Ta2O5 thin film for implant surface modification triggers superior anti-corrosion performance and cytocompatibility of titanium |
| title_full_unstemmed |
β-Ta2O5 thin film for implant surface modification triggers superior anti-corrosion performance and cytocompatibility of titanium |
| title_sort |
β-Ta2O5 thin film for implant surface modification triggers superior anti-corrosion performance and cytocompatibility of titanium |
| dc.creator.none.fl_str_mv |
Beline, Thamara de Almeida, Amanda B. Azevedo Neto, Nilton F. [UNESP] Matos, Adaias O. Ricomini-Filho, Antônio P. Sukotjo, Cortino Smeets, Paul J.M. da Silva, José H.D. [UNESP] Nociti, Francisco H. Barão, Valentim A.R. |
| author |
Beline, Thamara |
| author_facet |
Beline, Thamara de Almeida, Amanda B. Azevedo Neto, Nilton F. [UNESP] Matos, Adaias O. Ricomini-Filho, Antônio P. Sukotjo, Cortino Smeets, Paul J.M. da Silva, José H.D. [UNESP] Nociti, Francisco H. Barão, Valentim A.R. |
| author_role |
author |
| author2 |
de Almeida, Amanda B. Azevedo Neto, Nilton F. [UNESP] Matos, Adaias O. Ricomini-Filho, Antônio P. Sukotjo, Cortino Smeets, Paul J.M. da Silva, José H.D. [UNESP] Nociti, Francisco H. Barão, Valentim A.R. |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Tribocorrosion and Nanomedicine (IBTN) Universidade Estadual Paulista (Unesp) College of Dentistry Northwestern University |
| dc.subject.por.fl_str_mv |
Biomaterials Corrosion Dental implants Magnetron sputtering Protein adsorption Tantalum oxide |
| topic |
Biomaterials Corrosion Dental implants Magnetron sputtering Protein adsorption Tantalum oxide |
| description |
In this study, β-tantalum oxide (β-Ta2O5) thin film was synthesized via magnetron sputtering to improve the surface properties, cytocompatibility and electrochemical stability of titanium. X-ray diffraction analysis confirmed a crystalline orthorhombic phase of Ta2O5 film on the β-Ta2O5 experimental surface. A granular structure with a complex and hierarchical nature was demonstrated by atomic force microscopy. Ta2O5-treated surfaces exhibited greater roughness and hydrophilicity compared with untreated titanium discs (control). Enhanced electrochemical stability in simulated body fluid (pH 7.4) was noted for Ta2O5-treated surfaces wherein higher values of charge transfer resistance, nobler corrosion potential, and lower capacitance, corrosion current density, and corrosion rate values were observed vs untreated control. Real-time monitoring of albumin and fibrinogen proteins adsorption by an electrochemical quartz crystal microbalance disclosed similar protein interactions for control and Ta2O5-treated discs, with higher fibrinogen adsorption rates for Ta2O5-treated surfaces. Cell culture assays (MC3T3-E1 cells) demonstrated that Ta2O5-treated discs featured greater in vitro mineral nodule formation, normal cell morphology and spreading, and increased mRNA levels of runt-related transcription factor 2 (Runx-2), osteocalcin (Ocn), and collagen-1 (Col-1). Therefore, it can be concluded that β-Ta2O5 thin films may be considered a promising strategy to trigger superior long-term stability and biological properties of titanium implants. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-12-12T01:20:36Z 2020-12-12T01:20:36Z 2020-08-01 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.apsusc.2020.146326 Applied Surface Science, v. 520. 0169-4332 http://hdl.handle.net/11449/198732 10.1016/j.apsusc.2020.146326 2-s2.0-85083268587 |
| url |
http://dx.doi.org/10.1016/j.apsusc.2020.146326 http://hdl.handle.net/11449/198732 |
| identifier_str_mv |
Applied Surface Science, v. 520. 0169-4332 10.1016/j.apsusc.2020.146326 2-s2.0-85083268587 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Applied Surface Science |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
| instname_str |
Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
| institution |
UNESP |
| reponame_str |
Repositório Institucional da UNESP |
| collection |
Repositório Institucional da UNESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
| repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
| _version_ |
1853671781473189888 |
| score |
15.300719 |