In vivo effectiveness of hybrid membranes with osteogenic growth peptide for bone regeneration

Guided bone regeneration (GBR) technique helps to restore bone tissue through cellular selectivity principle. Currently no osteoinductive membrane exists on the market. Osteogenic growth peptide (OGP) acts as a hematopoietic stimulator. This association could improve the quality of bone formation, b...

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Detalhes bibliográficos
Autores: Oshiro-Junior, João Augusto [UNESP], Barros, Rafaela Moreno, da Silva, Camila Garcia [UNESP], de Souza, Caroline Cordeiro [UNESP], Scardueli, Cássio Rocha [UNESP], Marcantonio, Camila Chiérici [UNESP], da Silva Saches, Paulo Ricardo [UNESP], Mendes, Larissa [UNESP], Cilli, Eduardo Maffud [UNESP], Marcantonio, Rosemary Adriana Chierici [UNESP], Chiavacci, Leila Aparecida [UNESP]
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:Brasil
Recursos:Universidade Estadual Paulista (UNESP)
Repositório:Repositório Institucional da UNESP
Idioma:inglês
OAI Identifier:oai:repositorio.unesp.br:11449/207812
Acesso em linha:http://dx.doi.org/10.1002/term.3226
http://hdl.handle.net/11449/207812
Access Level:Acceso aberto
Palavra-chave:bone morphogenetic proteins
critical-sized bone defects
osteoinductive membrane
ureasil-polyether materials
Descrição
Resumo:Guided bone regeneration (GBR) technique helps to restore bone tissue through cellular selectivity principle. Currently no osteoinductive membrane exists on the market. Osteogenic growth peptide (OGP) acts as a hematopoietic stimulator. This association could improve the quality of bone formation, benefiting more than 2.2 million patients annually. The objective of this work was to develop membranes from ureasil-polyether materials containing OGP. The membranes were characterized by differential scanning calorimetry (DSC) and small angle X-ray scattering (SAXS). OGP was synthesized by the solid phase method. Sterilization results using gamma radiation at 24 kGy did not change the structure of the material, as confirmed by DSC. The SAXS technique revealed the structural homogeneity of the matrix. OGP was incorporated in 66.25 × 10−10 mol and release results showed that the ureasil-PPO400/PEO500 and ureasil-PPO400/PEO1900 membranes released 7% and 21%, respectively, after 48 h. In vivo results demonstrated that the amount and quality of bone tissue formed in the bone defects in the presence of ureasil-polyether membranes with OGP were similar to commercial collagen material with BMP. The results allow us to conclude that membranes with OGP have characteristics that make them potential candidates for the GBR.

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