Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging

In Alzheimer’s disease (AD), neuropsychiatric symptoms (NPS) correlate with tau deposition in the brain. Here, we investigated the association of PET-based Braak stages with NPS and assessed whether they predict annual changes in NPS. We evaluated 231 individuals in the aging and AD continuum. Parti...

Descripción completa

Detalles Bibliográficos
Autores: Macedo, Arthur C., Zimmer, Eduardo Rigon, Rosa Neto, Pedro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:Brasil
Institución:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/282174
Acceso en línea:http://hdl.handle.net/10183/282174
Access Level:acceso abierto
Palabra clave:Doenças neurodegenerativas
Doença de Alzheimer
Demência
Proteínas tau
Emaranhados neurofibrilares
Alzheimer’s disease
Positron emission tomography
Neuropsychiatric symptom
Neurofibrillary tangles
Braak staging
Dementia
id BR_e673e2cddd7c768f921e1ee55dc8171d
oai_identifier_str oai:www.lume.ufrgs.br:10183/282174
network_acronym_str BR
network_name_str Brasil
repository_id_str
spelling 2024-12-06T06:44:00Z20241558-1497http://hdl.handle.net/10183/282174001213007In Alzheimer’s disease (AD), neuropsychiatric symptoms (NPS) correlate with tau deposition in the brain. Here, we investigated the association of PET-based Braak stages with NPS and assessed whether they predict annual changes in NPS. We evaluated 231 individuals in the aging and AD continuum. Participants were assigned a Braak stage at baseline and followed for 1.97 (s.d. 0.62) years. NPS were investigated using the Mild Behavioral Impairment Checklist (MBI-C) and the Neuropsychiatric Inventory Questionnaire severity (NPI-Q-S) and distress (NPI-Q-D) scales. Multiple linear regressions (MLR) assessed the association of Braak stages with baseline NPS and the annual change in NPS scores. At baseline, stages I-II, III-IV, and V-VI were associated with higher MBI-C, NPI-Q-S, and NPI-Q-D scores. Stages V-VI were associated with a significant annual increase in MBI-C scores. These findings suggest that tau accumulation may manifest clinically with an increase in NPS, which seems to be an early event in AD pathophysiology. Moreover, PET-based Braak staging appears to be a good predictor of NPS severity progression.application/pdfengNeurobiology of aging. New York. Vol. 144 (Dec. 2024), p. 127-137Doenças neurodegenerativasDoença de AlzheimerDemênciaProteínas tauEmaranhados neurofibrilaresAlzheimer’s diseasePositron emission tomographyNeuropsychiatric symptomNeurofibrillary tanglesBraak stagingDementiaModeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak stagingEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSMacedo, Arthur C.Zimmer, Eduardo RigonRosa Neto, PedroTEXT001213007.pdf.txt001213007.pdf.txtExtracted Texttext/plain71334http://www.lume.ufrgs.br/bitstream/10183/282174/2/001213007.pdf.txt5f270abf4c996e023057ff2bec431614MD52ORIGINAL001213007.pdfTexto completo (inglês)application/pdf2255302http://www.lume.ufrgs.br/bitstream/10183/282174/1/001213007.pdfea21bddd8611598d3f0d1b9ac4a759faMD5110183/2821742024-12-07 07:48:28.089923oai:www.lume.ufrgs.br:10183/282174Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2024-12-07T09:48:28Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging
title Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging
spellingShingle Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging
Macedo, Arthur C.
Doenças neurodegenerativas
Doença de Alzheimer
Demência
Proteínas tau
Emaranhados neurofibrilares
Alzheimer’s disease
Positron emission tomography
Neuropsychiatric symptom
Neurofibrillary tangles
Braak staging
Dementia
title_short Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging
title_full Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging
title_fullStr Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging
title_full_unstemmed Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging
title_sort Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging
dc.creator.none.fl_str_mv Macedo, Arthur C.
Zimmer, Eduardo Rigon
Rosa Neto, Pedro
author Macedo, Arthur C.
author_facet Macedo, Arthur C.
Zimmer, Eduardo Rigon
Rosa Neto, Pedro
author_role author
author2 Zimmer, Eduardo Rigon
Rosa Neto, Pedro
author2_role author
author
dc.subject.por.fl_str_mv Doenças neurodegenerativas
Doença de Alzheimer
Demência
Proteínas tau
Emaranhados neurofibrilares
topic Doenças neurodegenerativas
Doença de Alzheimer
Demência
Proteínas tau
Emaranhados neurofibrilares
Alzheimer’s disease
Positron emission tomography
Neuropsychiatric symptom
Neurofibrillary tangles
Braak staging
Dementia
dc.subject.eng.fl_str_mv Alzheimer’s disease
Positron emission tomography
Neuropsychiatric symptom
Neurofibrillary tangles
Braak staging
Dementia
description In Alzheimer’s disease (AD), neuropsychiatric symptoms (NPS) correlate with tau deposition in the brain. Here, we investigated the association of PET-based Braak stages with NPS and assessed whether they predict annual changes in NPS. We evaluated 231 individuals in the aging and AD continuum. Participants were assigned a Braak stage at baseline and followed for 1.97 (s.d. 0.62) years. NPS were investigated using the Mild Behavioral Impairment Checklist (MBI-C) and the Neuropsychiatric Inventory Questionnaire severity (NPI-Q-S) and distress (NPI-Q-D) scales. Multiple linear regressions (MLR) assessed the association of Braak stages with baseline NPS and the annual change in NPS scores. At baseline, stages I-II, III-IV, and V-VI were associated with higher MBI-C, NPI-Q-S, and NPI-Q-D scores. Stages V-VI were associated with a significant annual increase in MBI-C scores. These findings suggest that tau accumulation may manifest clinically with an increase in NPS, which seems to be an early event in AD pathophysiology. Moreover, PET-based Braak staging appears to be a good predictor of NPS severity progression.
publishDate 2024
dc.date.accessioned.fl_str_mv 2024-12-06T06:44:00Z
dc.date.issued.fl_str_mv 2024
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/282174
dc.identifier.issn.pt_BR.fl_str_mv 1558-1497
dc.identifier.nrb.pt_BR.fl_str_mv 001213007
identifier_str_mv 1558-1497
001213007
url http://hdl.handle.net/10183/282174
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Neurobiology of aging. New York. Vol. 144 (Dec. 2024), p. 127-137
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/282174/2/001213007.pdf.txt
http://www.lume.ufrgs.br/bitstream/10183/282174/1/001213007.pdf
bitstream.checksum.fl_str_mv 5f270abf4c996e023057ff2bec431614
ea21bddd8611598d3f0d1b9ac4a759fa
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv lume@ufrgs.br
_version_ 1853662861550682112
score 15,127369

Similares en LA Referencia