Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges
The potential of stem cell-based therapy was accompanied by high expectations and led, consequently, to an increase in clinical translational investments. Mesenchymal stem/stromal cells (MSCs) became the cell-based product most experimentally studied worldwide. However, uncertainties about the mecha...
| Authors: | , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2021 |
| Country: | Brasil |
| Institution: | Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
| Repository: | Brazilian Journal of Veterinary Medicine |
| Language: | English |
| OAI Identifier: | oai:ojs.rbmv.org:article/1120 |
| Online Access: | https://bjvm.org.br/BJVM/article/view/1120 |
| Access Level: | Open access |
| Keyword: | Células-tronco, Células tronco mesenquimais, Células mesenquimais estromais, Terapia celular Stem cells, Mesenchymal stem/stromal cells, Cell therapy |
| Summary: | The potential of stem cell-based therapy was accompanied by high expectations and led, consequently, to an increase in clinical translational investments. Mesenchymal stem/stromal cells (MSCs) became the cell-based product most experimentally studied worldwide. However, uncertainties about the mechanisms and the in vivo identity of MSCs impose concerns about their large-scale use in regenerative medicine. This review comprises a historical summary on MSC, a critical discussion about their identity and function, and the ongoing challenges for their use in therapy and tissue bioengineering. |
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