Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy

We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that c...

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Detalles Bibliográficos
Autores: Almeida, Sandro Soares [UNIFESP], Naffah-Mazzacoratti, Maria da Graca [UNIFESP], Guimarães, Paola Bianchi [UNIFESP], Wasinski, Frederick [UNIFESP], Pereira, Flavia Enira Gomes [UNIFESP], Canzian, Mauro [UNIFESP], Centeno, Ricardo Silva [UNIFESP], Carrete Junior, Henrique [UNIFESP], Yacubian, Elza Márcia Targas [UNIFESP], Carmona, Adriana Karaoglanovic [UNIFESP], Vieira, Renata de Freitas Fischer [UNIFESP], Nakaie, Clovis Ryuichi [UNIFESP], Sabatini, Regiane Angelica [UNIFESP], Perosa, Sandra Regina [UNIFESP], Bacurau, Reury Frank Pereira, Gouveia, Telma Luciana Furtado [UNIFESP], Gallo, Gloria [UNIFESP], Wuertele, Martin [UNIFESP], Cavalheiro, Esper Abrão [UNIFESP], Silva Junior, Jose Antonio [UNIFESP], Pesquero, João Bosco [UNIFESP], Araujo, Ronaldo de Carvalho [UNIFESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Brasil
Institución:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/34639
Acceso en línea:https://dx.doi.org/10.1038/tp.2012.21
https://repositorio.unifesp.br/handle/11600/34639
Access Level:acceso abierto
Palabra clave:Angiotensin I-converting enzyme
Carbamazepine
Epilepsy
TLE
Descripción
Sumario:We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems. Translational Psychiatry (2012) 2, e93; doi:10.1038/tp.2012.21; published online 13 March 2012

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