Antinociceptive Effect of the Monoterpene R-()-Limonene in Mice
In the present study were studied the antinociceptives properties of monoterpene R-()-limonene (LM) in chemical and thermal models of nociception in mice. The R-()-limonene was administered, intraperitoneally(i.p.), at doses of 25 and 50 mg/kg. The results showed significant inhibition produced on c...
| Autores: | , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2007 |
| País: | Brasil |
| Institución: | Universidade Federal do Ceará (UFC) |
| Repositorio: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.ufc.br:riufc/82680 |
| Acceso en línea: | http://repositorio.ufc.br/handle/riufc/82680 |
| Access Level: | acceso abierto |
| Palabra clave: | R-()-limonene antinociceptive naloxone |
| Sumario: | In the present study were studied the antinociceptives properties of monoterpene R-()-limonene (LM) in chemical and thermal models of nociception in mice. The R-()-limonene was administered, intraperitoneally(i.p.), at doses of 25 and 50 mg/kg. The results showed significant inhibition produced on chemical nociception induced by intraperitoneal acetic-acid and in the second phase of subplantar formalin test, but did not manifest a significant effect in hot-plate test. The R-()-limonene-induced antinociception in second phase of formalin test was insensitive to naloxone (1 mg/kg, s.c.). It was also demonstrated that R-()-limonene (25, 50 mg/kg) neither significantly enhanced the pentobarbital-sleeping time nor impaired the motor performance in rota-rod test, indicating that the observed antinociception is unlikely to be due to sedation or motor abnormality. In conclusion it may be suggested that the R-()-limonene presented antinociceptive activity and that, probably, this action can be related with peripheral analgesia, but, not with the stimulation of opioids receptors. |
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