The role of senescent CD8+T cells in the pathogenesis of disseminated leishmaniasis

National Institutes of Health (NIH).

Detalles Bibliográficos
Autores: Abreu, Cayo A., Nascimento, Maurício Teixeira, Bacellar, Olívia, Carvalho, Lucas Pedreira, Carvalho, Edgar Marcelino, Cardoso, Thiago Marconi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:Brasil
Institución:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/65220
Acceso en línea:https://arca.fiocruz.br/handle/icict/65220
Access Level:acceso abierto
Palabra clave:Disseminado
Leishmaniose
Células T CD8+
Senescentes
Disseminated
Leishmaniasis
CD8+T cells
Senescent
Linfócitos T CD8-Positivos
id BR_df80cfe50d3ccfc2ef4f969c78ef929f
oai_identifier_str oai:arca.fiocruz.br:icict/65220
network_acronym_str BR
network_name_str Brasil
repository_id_str
dc.title.none.fl_str_mv The role of senescent CD8+T cells in the pathogenesis of disseminated leishmaniasis
title The role of senescent CD8+T cells in the pathogenesis of disseminated leishmaniasis
spellingShingle The role of senescent CD8+T cells in the pathogenesis of disseminated leishmaniasis
Abreu, Cayo A.
Disseminado
Leishmaniose
Células T CD8+
Senescentes
Disseminated
Leishmaniasis
CD8+T cells
Senescent
Leishmaniose
Linfócitos T CD8-Positivos
title_short The role of senescent CD8+T cells in the pathogenesis of disseminated leishmaniasis
title_full The role of senescent CD8+T cells in the pathogenesis of disseminated leishmaniasis
title_fullStr The role of senescent CD8+T cells in the pathogenesis of disseminated leishmaniasis
title_full_unstemmed The role of senescent CD8+T cells in the pathogenesis of disseminated leishmaniasis
title_sort The role of senescent CD8+T cells in the pathogenesis of disseminated leishmaniasis
dc.creator.none.fl_str_mv Abreu, Cayo A.
Nascimento, Maurício Teixeira
Bacellar, Olívia
Carvalho, Lucas Pedreira
Carvalho, Edgar Marcelino
Cardoso, Thiago Marconi
author Abreu, Cayo A.
author_facet Abreu, Cayo A.
Nascimento, Maurício Teixeira
Bacellar, Olívia
Carvalho, Lucas Pedreira
Carvalho, Edgar Marcelino
Cardoso, Thiago Marconi
author_role author
author2 Nascimento, Maurício Teixeira
Bacellar, Olívia
Carvalho, Lucas Pedreira
Carvalho, Edgar Marcelino
Cardoso, Thiago Marconi
author2_role author
author
author
author
author
dc.subject.other.none.fl_str_mv Disseminado
Leishmaniose
Células T CD8+
Senescentes
topic Disseminado
Leishmaniose
Células T CD8+
Senescentes
Disseminated
Leishmaniasis
CD8+T cells
Senescent
Leishmaniose
Linfócitos T CD8-Positivos
dc.subject.en.none.fl_str_mv Disseminated
Leishmaniasis
CD8+T cells
Senescent
dc.subject.decs.none.fl_str_mv Leishmaniose
Linfócitos T CD8-Positivos
description National Institutes of Health (NIH).
publishDate 2024
dc.date.accessioned.fl_str_mv 2024-07-31T17:27:18Z
dc.date.available.fl_str_mv 2024-07-31T17:27:18Z
dc.date.issued.fl_str_mv 2024
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ABREU, Cayo A. et al. The role of senescent CD8+T cells in the pathogenesis of disseminated leishmaniasis. Pathogens, v. 13, n. 6, p. 1-14, 2024.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/65220
dc.identifier.issn.none.fl_str_mv 2076-0817
dc.identifier.doi.none.fl_str_mv 10.3390/ pathogens13060460
identifier_str_mv ABREU, Cayo A. et al. The role of senescent CD8+T cells in the pathogenesis of disseminated leishmaniasis. Pathogens, v. 13, n. 6, p. 1-14, 2024.
2076-0817
10.3390/ pathogens13060460
url https://arca.fiocruz.br/handle/icict/65220
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2024-07-31T17:27:18Z2024-07-31T17:27:18Z2024ABREU, Cayo A. et al. The role of senescent CD8+T cells in the pathogenesis of disseminated leishmaniasis. Pathogens, v. 13, n. 6, p. 1-14, 2024.2076-0817https://arca.fiocruz.br/handle/icict/6522010.3390/ pathogens13060460National Institutes of Health (NIH).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil.Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil / Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil / Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil / Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil.Disseminated leishmaniasis (DL) caused by L. braziliensis is characterized by the presence of 10 to more than 1000 lesions spread on the body. While protection against Leishmania is mediated by macrophages upon activation by IFN-γ produced by CD4+T cells, the pathology of disseminated leishmaniasis (DL) could be mediated by macrophages, NK, and CD8+T cells. Herein, we evaluate the participation of senescent CD8+T cells in the pathogenesis of DL. Methods: Peripheral blood mononuclear cells (PBMCs), biopsies, co-cultures of CD8+T cells with uninfected and infected macrophages (MØ), and PBMC cultures stimulated with soluble L. braziliensis antigen (SLA) for 72 h from patients with cutaneous leishmaniasis (CL) and DL were used to characterize senescent CD8+T cells. Statistical analysis was performed using the Mann–Whitney and Kruskal–Wallis tests, followed by Dunn's. Results: Patients with DL have an increase in the frequency of circulating CD8+T cells that present a memory/senescent phenotype, while lesions from DL patients have an increase in the frequency of infiltrating CD8+T cells with a senescent/degranulation phenotype. In addition, after specific stimuli, DL patients' circulating CD8+T with memory/senescent profile, showing degranulation characteristics, increased upon SLA stimuli, and those specific CD8+T cells from DL patients had an increased degranulation phenotype, causing more apoptosis of infected target cells. Conclusions: DL patients show a higher frequency of cytotoxic senescent CD8+T cells compared to CL patients, and that could promote the lysis of infected cells, although without parasite killing, releasing Leishmania to the extracellular compartment, contributing to the spread of parasites.engMDPIDisseminadoLeishmanioseCélulas T CD8+SenescentesDisseminatedLeishmaniasisCD8+T cellsSenescentLeishmanioseLinfócitos T CD8-PositivosThe role of senescent CD8+T cells in the pathogenesis of disseminated leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZAbreu, Cayo A.Nascimento, Maurício TeixeiraBacellar, OlíviaCarvalho, Lucas PedreiraCarvalho, Edgar MarcelinoCardoso, Thiago MarconiLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/71f176a0-e635-4b2b-ba28-a7a767740711/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALAbreu, Cayo A. - 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score 15.301629

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