Repair capacity of Taenia solium extraparenchymal cysts: radiological and in vitro evidence
Extraparenchymal neurocysticercosis (EP-NC) responds poorly to anthelmintic treatment. Several factors are involved in this low responsiveness, including the host’s heterogeneous immune response and the ability of the parasite to evade it. In this study, we present radiological and in vitro findings...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/298437 |
| Acceso en línea: | http://dx.doi.org/10.1080/17460913.2025.2472594 https://hdl.handle.net/11449/298437 |
| Access Level: | acceso abierto |
| Palabra clave: | extraparenchymal neurocysticercosis in vitro tests magnetic resonance imaging Neurocysticercosis Taenia solium |
| Sumario: | Extraparenchymal neurocysticercosis (EP-NC) responds poorly to anthelmintic treatment. Several factors are involved in this low responsiveness, including the host’s heterogeneous immune response and the ability of the parasite to evade it. In this study, we present radiological and in vitro findings that demonstrate that Taenia solium cysts have the capacity to repair from injuries. Six patients (three with cases of subarachnoid, two with cases of intraventricular, and one with a case of mixed subarachnoid and intraventricular cysts) presented with neurological complaints and underwent either medical or surgical treatment. Follow-up magnetic resonance imaging (MRI) showed apparent resolution of the cysts. However, months later (10–56) new MRI scans revealed cysts at the same sites observed before treatment. Cysts surgically removed were maintained in RPMI-1640 medium supplemented with 10% fetal bovine serum. Monthly assessments demonstrated the growth of the parasites and the release of HP-10. Our findings demonstrate the ability of T. solium extraparenchymal cysts to grow and repair themselves. This capacity is likely another factor involved in the disease’s poor treatment response. |
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