Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania.

Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacinand PH8 monovalent vaccine yielded the highest IFN-levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immuni...

Descripción completa

Detalles Bibliográficos
Autores: Mayrink, Wilson, Santos, Gilmara Cristina dos, Toledo, Vicente de Paulo Coelho Peixoto de, Guimarães, Tânia Mara Pinto Dabés, Coelho, George Luiz Lins Machado, Genaro, Odair, Costa, Carlos Alberto da
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2002
País:Brasil
Institución:Universidade Federal de Ouro Preto (UFOP)
Repositorio:Repositório Institucional da UFOP
Idioma:inglés
OAI Identifier:oai:repositorio.ufop.br:123456789/3764
Acceso en línea:http://www.repositorio.ufop.br/handle/123456789/3764
http://dx.doi.org/10.1590/S0037-86822002000200001
Access Level:acceso abierto
Palabra clave:Vaccine
Interferon
Interleukin
Leishmania
Vacina
Descripción
Sumario:Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacinand PH8 monovalent vaccine yielded the highest IFN-levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection.

Similares en LA Referencia