Analysis of liver fragment subjected to autologous transplant at rat’s retroperitoneum.
Background: To investigate the regeneration process of autologous implants of liver on the retroperitoneum. Methods: Thirty male Fisher rats were used divided in to group 1 (G1): studied 60 d after surgery; group 2 (G2): studied 90 d after surgery; group 3 (G3): studied 180 d after surgery; and grou...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | Brasil |
| Institución: | Universidade Federal de Ouro Preto (UFOP) |
| Repositorio: | Repositório Institucional da UFOP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.ufop.br:123456789/6676 |
| Acceso en línea: | http://www.repositorio.ufop.br/handle/123456789/6676 https://doi.org/10.1016/j.jss.2015.06.029 |
| Access Level: | acceso abierto |
| Palabra clave: | Hepatic regeneration Autotransplantation Experimental surgery |
| Sumario: | Background: To investigate the regeneration process of autologous implants of liver on the retroperitoneum. Methods: Thirty male Fisher rats were used divided in to group 1 (G1): studied 60 d after surgery; group 2 (G2): studied 90 d after surgery; group 3 (G3): studied 180 d after surgery; and group C (GC): animals without surgery. Hepatic fragment was processed for histologic and biochemical analysis. Results: There was inflammatory infiltrate, diffuse hydropic degeneration, necrosis, and moderate fibrosis that reduced in direct relation to the postsurgical time. The concentration of albuminwas differentbetweenGCandG1 and betweenG1 andG3 (P¼0.0007).The Catalase (CAT) was related to the time of surgery with GC being different when compared with G1, G2, and G3 (P < 0.0001). The oxidative stress measured through the thiobarbituric acid reactive substances lipid peroxidation was different between the GC and the G2 groups (P ¼ 0.0381). Conclusions: The analysis made showed hepatic regeneration in the fragment subjected to autologous transplant at the retroperitoneum |
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