Efficacy of a triple therapy for Helicobacter pylori eradication in a well-developed urban area in Brazil

CONTEXT: Helicobacter pylori eradication has become the standard treatment for peptic ulcer disease. Triple therapy with omeprazole plus two antibiotics has been used. Due to the lack of ideal treatment and the high rates of primary resistance to nitroimidazoles, the use of clarithromycin has been a...

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Autores: Bellelis, Patrick, Samano, Eliana Sueco Tibana, Nunes, Ricardo Cruz, Ribeiro, Lia de Melo, Chehter, Ethel Zimberg, Catapani, Wilson Roberto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2004
País:Brasil
Institución:Associação Paulista de Medicina
Repositorio:São Paulo medical journal (Online)
Idioma:inglés
OAI Identifier:oai:ojs.diagnosticoetratamento.emnuvens.com.br:article/2490
Acceso en línea:https://periodicosapm.emnuvens.com.br/spmj/article/view/2490
Access Level:acceso abierto
Palabra clave:Tratamento
Úlcera péptica
Helicobacter pylori
Antibióticos
Úlcera gástrica
Úlcera duodenal
Antibiotics
Therapy
Duodenal ulcer
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network_name_str Brasil
repository_id_str
dc.title.none.fl_str_mv Efficacy of a triple therapy for Helicobacter pylori eradication in a well-developed urban area in Brazil
Eficácia do esquema tríplice na erradicação da Helicobacter pylori em região urbana desenvolvida de São Paulo
title Efficacy of a triple therapy for Helicobacter pylori eradication in a well-developed urban area in Brazil
spellingShingle Efficacy of a triple therapy for Helicobacter pylori eradication in a well-developed urban area in Brazil
Bellelis, Patrick
Tratamento
Úlcera péptica
Helicobacter pylori
Antibióticos
Úlcera gástrica
Úlcera duodenal
Helicobacter pylori
Antibiotics
Therapy
Duodenal ulcer
title_short Efficacy of a triple therapy for Helicobacter pylori eradication in a well-developed urban area in Brazil
title_full Efficacy of a triple therapy for Helicobacter pylori eradication in a well-developed urban area in Brazil
title_fullStr Efficacy of a triple therapy for Helicobacter pylori eradication in a well-developed urban area in Brazil
title_full_unstemmed Efficacy of a triple therapy for Helicobacter pylori eradication in a well-developed urban area in Brazil
title_sort Efficacy of a triple therapy for Helicobacter pylori eradication in a well-developed urban area in Brazil
dc.creator.none.fl_str_mv Bellelis, Patrick
Samano, Eliana Sueco Tibana
Nunes, Ricardo Cruz
Ribeiro, Lia de Melo
Chehter, Ethel Zimberg
Catapani, Wilson Roberto
author Bellelis, Patrick
author_facet Bellelis, Patrick
Samano, Eliana Sueco Tibana
Nunes, Ricardo Cruz
Ribeiro, Lia de Melo
Chehter, Ethel Zimberg
Catapani, Wilson Roberto
author_role author
author2 Samano, Eliana Sueco Tibana
Nunes, Ricardo Cruz
Ribeiro, Lia de Melo
Chehter, Ethel Zimberg
Catapani, Wilson Roberto
author2_role author
author
author
author
author
dc.subject.por.fl_str_mv Tratamento
Úlcera péptica
Helicobacter pylori
Antibióticos
Úlcera gástrica
Úlcera duodenal
Helicobacter pylori
Antibiotics
Therapy
Duodenal ulcer
topic Tratamento
Úlcera péptica
Helicobacter pylori
Antibióticos
Úlcera gástrica
Úlcera duodenal
Helicobacter pylori
Antibiotics
Therapy
Duodenal ulcer
description CONTEXT: Helicobacter pylori eradication has become the standard treatment for peptic ulcer disease. Triple therapy with omeprazole plus two antibiotics has been used. Due to the lack of ideal treatment and the high rates of primary resistance to nitroimidazoles, the use of clarithromycin has been adopted. OBJECTIVE: To determine the Helicobacter pylori eradication rates using lansoprazole, amoxicillin and clarithromycin for seven days, in patients with peptic ulcer disease in a well developed urban area in Brazil. METHODS: This was a retrospective, open-label study carried out at the School of Medicine of the Fundação ABC. It included 130 patients with peptic ulcer disease (upper endoscopy) who had been tested positive for Helicobacter pylori infection (urease test, histology or breath test), without previous treatment. Patients were treated with lansoprazole 30 mg, amoxicillin 1,000 mg and clarithromycin 500 mg b.i.d., for seven days. Eradication was verified after 90 days. RESULTS: Follow-up data were available for 94 patients. Their mean age was 52.23 years; 51.54% were woman, 84.31% white, 37.69% smokers, 20.77% using nonsteroidal anti-inflammatory drugs and 8.46% alcoholics. Upper endoscopy revealed that 78.46% had duodenal ulcers and 21.53% had gastric ulcers (a 4:1 DU:GU ratio). The eradication rates were 85.11% per protocol and 61.54% by intention to treat; 97% had no adverse effects. CONCLUSION: Triple therapy using lansoprazole, amoxicillin and clarithromycin is well tolerated with high eradication rates and forms a good alternative for developing countries.
publishDate 2004
dc.date.none.fl_str_mv 2004-03-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicosapm.emnuvens.com.br/spmj/article/view/2490
url https://periodicosapm.emnuvens.com.br/spmj/article/view/2490
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicosapm.emnuvens.com.br/spmj/article/view/2490/2376
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv São Paulo Medical Journal
São Paulo Medical Journal
publisher.none.fl_str_mv São Paulo Medical Journal
São Paulo Medical Journal
dc.source.none.fl_str_mv São Paulo Medical Journal; Vol. 122 No. 2 (2004); 73-75
São Paulo Medical Journal; v. 122 n. 2 (2004); 73-75
1806-9460
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
_version_ 1853676246999760896
spelling Efficacy of a triple therapy for Helicobacter pylori eradication in a well-developed urban area in BrazilEficácia do esquema tríplice na erradicação da Helicobacter pylori em região urbana desenvolvida de São PauloTratamentoÚlcera pépticaHelicobacter pyloriAntibióticosÚlcera gástricaÚlcera duodenalHelicobacter pyloriAntibioticsTherapyDuodenal ulcerCONTEXT: Helicobacter pylori eradication has become the standard treatment for peptic ulcer disease. Triple therapy with omeprazole plus two antibiotics has been used. Due to the lack of ideal treatment and the high rates of primary resistance to nitroimidazoles, the use of clarithromycin has been adopted. OBJECTIVE: To determine the Helicobacter pylori eradication rates using lansoprazole, amoxicillin and clarithromycin for seven days, in patients with peptic ulcer disease in a well developed urban area in Brazil. METHODS: This was a retrospective, open-label study carried out at the School of Medicine of the Fundação ABC. It included 130 patients with peptic ulcer disease (upper endoscopy) who had been tested positive for Helicobacter pylori infection (urease test, histology or breath test), without previous treatment. Patients were treated with lansoprazole 30 mg, amoxicillin 1,000 mg and clarithromycin 500 mg b.i.d., for seven days. Eradication was verified after 90 days. RESULTS: Follow-up data were available for 94 patients. Their mean age was 52.23 years; 51.54% were woman, 84.31% white, 37.69% smokers, 20.77% using nonsteroidal anti-inflammatory drugs and 8.46% alcoholics. Upper endoscopy revealed that 78.46% had duodenal ulcers and 21.53% had gastric ulcers (a 4:1 DU:GU ratio). The eradication rates were 85.11% per protocol and 61.54% by intention to treat; 97% had no adverse effects. CONCLUSION: Triple therapy using lansoprazole, amoxicillin and clarithromycin is well tolerated with high eradication rates and forms a good alternative for developing countries.CONTEXTO: A erradicação do Helicobacter pylori tem sido o principal tratamento para a doença ulcerosa péptica. Consiste em uma terapia tripla com omeprazol juntamente com dois antibióticos. Devido à inexistência de uma medicação ideal, assim como a um alto índice de resistência primária aos nitroimidazólicos em nosso meio, tem-se adotado o uso da claritromicina. OBJETIVOS: Determinar o índice de erradicação do Helicobacter pylori em pacientes com doença ulcerosa péptica mediante a terapia com lanzoprazol, amoxicilina e claritromicina, por sete dias. MÉTODOS: Num estudo retrospectivo, aberto e realizado na Faculdade de Medicina do ABC, foram incluídos 130 pacientes portadores de doença ulcerosa péptica (endoscopia digestiva alta) e com infecção por Helicobacter pylori diagnosticada pelos testes da urease, respiratório e histológico; todos sem tratamento prévio. Os pacientes foram tratados com lanzoprazol (30 mg), amoxicilina (1.000 mg) e claritromicina (500 mg) duas vezes ao dia por sete dias. Os índices de erradicação foram avaliados noventa dias após o tratamento. RESULTADOS: 94 pacientes completaram o estudo, sendo a média de idade 52,23 anos, 51,54% mulheres, 84,31% brancos, 37,69% tabagistas, 20,77% usuários de antiinflamatórios não-hormonais e 8,46% de etilistas. A endoscopia digestiva alta revelou: 78,46% de úlcera duodenal (UD) e 21,53% de úlcera gástrica (UG) (4UD:1UG). O índice de erradicação por protocolo foi de 85,11% e por intenção de tratamento foi de 97%. Foram observados poucos efeitos colaterais. CONCLUSÃO: A terapia tríplice com lanzoprazol, amoxicilina e claritromicina mostrou-se bem tolerável, com altos índices de erradicação, sendo uma boa alternativa para países em desenvolvimento.São Paulo Medical JournalSão Paulo Medical Journal2004-03-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicosapm.emnuvens.com.br/spmj/article/view/2490São Paulo Medical Journal; Vol. 122 No. 2 (2004); 73-75São Paulo Medical Journal; v. 122 n. 2 (2004); 73-751806-9460reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APMenghttps://periodicosapm.emnuvens.com.br/spmj/article/view/2490/2376https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBellelis, PatrickSamano, Eliana Sueco TibanaNunes, Ricardo CruzRibeiro, Lia de MeloChehter, Ethel ZimbergCatapani, Wilson Roberto2023-10-05T18:21:55Zoai:ojs.diagnosticoetratamento.emnuvens.com.br:article/2490Revistahttp://www.scielo.br/spmjPUBhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2023-10-05T18:21:55São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
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