Effectiveness and safety of anti-TNF therapy for ankylosing spondylitis: a real-world study
Aim: To evaluate the effectiveness and safety of anti-TNF drugs for ankylosing spondylitis. Materials & methods: A prospective cohort study was performed at a pharmacy in the Brazilian Public Health System. Effectiveness by Bath Ankylosing Spondylitis Disease Activity Index, functionality by Hea...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | Brasil |
| Institución: | Universidade Federal de Minas Gerais (UFMG) |
| Repositorio: | Repositório Institucional da UFMG |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.ufmg.br:1843/56515 |
| Acceso en línea: | https://becarispublishing.com/doi/10.2217/cer-2020-0275 http://hdl.handle.net/1843/56515 https://orcid.org/0000-0003-4024-0108 https://orcid.org/0000-0003-2550-7249 https://orcid.org/0000-0002-5528-0658 https://orcid.org/0000-0001-9411-7493 https://orcid.org/0000-0002-5880-5261 https://orcid.org/0000-0002-0210-0721 |
| Access Level: | acceso abierto |
| Palabra clave: | Ankylosing spondylitis Effectiveness Observational study Safety Tumor necrosis factor inhibitors Espondilite anquilosante Eficacia Inibidores |
| Sumario: | Aim: To evaluate the effectiveness and safety of anti-TNF drugs for ankylosing spondylitis. Materials & methods: A prospective cohort study was performed at a pharmacy in the Brazilian Public Health System. Effectiveness by Bath Ankylosing Spondylitis Disease Activity Index, functionality by Health Assessment Questionnaire Disability Index, quality of life by European Quality of Life Five-Dimensions and safety was assessed at 6 and 12 months of follow-up. Results: About 160 patients started the treatment with adalimumab, etanercept or infliximab. There was a statistically significant improvement in disease activity, functionality and quality of life at 6 and 12 months (p < 0.05). Conclusion: This real-world study has shown that anti-TNF drugs are effective and well tolerated for ankylosing spondylitis patients. |
|---|