Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts

Abstract This study aims to evaluate the secondary metabolites, cytotoxicity, antioxidant, antidiabetic, anti-inflammatory, and anticancer activities of four selected seaweeds Padina pavonica, Taonia atomaria, Jania rubens, and Corallina elongata. The maximum value of phenolic content (176.7 ± 6.9 m...

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Authors: SHAFAY,Shimaa EL, EL-SHEEKH,Mostafa, BASES,Eman, EL-SHENODY,Rania
Format: article
Status:Published version
Publication Date:2022
Country:Brasil
Institution:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
Repository:Food Science and Technology (Campinas)
Language:English
OAI Identifier:oai:scielo:S0101-20612022000100698
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100698
Access Level:Open access
Keyword:seaweeds
secondary metabolites
antioxidant
antidiabetic
anti-inflammatory
cytotoxicity
anticancer
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spelling Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extractsseaweedssecondary metabolitesantioxidantantidiabeticanti-inflammatorycytotoxicityanticancerAbstract This study aims to evaluate the secondary metabolites, cytotoxicity, antioxidant, antidiabetic, anti-inflammatory, and anticancer activities of four selected seaweeds Padina pavonica, Taonia atomaria, Jania rubens, and Corallina elongata. The maximum value of phenolic content (176.7 ± 6.9 mg gallic acid equivalents/g crude extract) and tannin content (26.5 ± 4.3 mg tannic acid equivalents/g crude extract), was shown in the methanol extract of J. rubens and P. pavonica, respectively. While the ethanol extract of T. atomaria recorded the highest values of total flavonoid content (374.1 ±27.4 mg quercetin equivalents/g crude extract) and total saponins content (30.2 ± 0.7 mg cholesterol equivalents/g crude extract, respectively) compared to other seaweeds. Methanol extract of J. rubens and C. elongata exhibited the greatest content of alkaloids (25.8 ± 4.4 and 22.7 ± 2.6 mg/g d wt.). The methanol extract of P. pavonica established the highest DPPH radical scavenging activity (55.7% ± 0.1) at 50 μg/mL. Among the selected seaweed extracts, the ethanol extract of T. atomaria demonstrated the maximum α-amylase inhibition capacity (66.3% ± 0.0). Methanol extract of J. rubens and P. pavonica species effectively prevented the hypotonicity-induced haemolysis in a concentration-dependent manner compared with the diclofenac potassium as a standard anti-inflammatory drug. In vitro, the reported results also supported the safety and non-toxicity of the four seaweed extracts on WI-38 cell line at lower concentrations. J. rubens and P. pavonica methanol extracts recorded the highest cell growth inhibition of the HeLa Cancer Cell Lines compared to other seaweed extracts and the standard drug Cisplatin.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100698Food Science and Technology v.42 2022reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.20521info:eu-repo/semantics/openAccessengSHAFAY,Shimaa ELEL-SHEEKH,MostafaBASES,EmanEL-SHENODY,Rania2022-02-22T00:00:00Zoai:scielo:S0101-20612022000100698Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2022-02-22T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false
dc.title.none.fl_str_mv Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts
title Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts
spellingShingle Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts
SHAFAY,Shimaa EL
seaweeds
secondary metabolites
antioxidant
antidiabetic
anti-inflammatory
cytotoxicity
anticancer
title_short Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts
title_full Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts
title_fullStr Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts
title_full_unstemmed Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts
title_sort Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts
dc.creator.none.fl_str_mv SHAFAY,Shimaa EL
EL-SHEEKH,Mostafa
BASES,Eman
EL-SHENODY,Rania
author SHAFAY,Shimaa EL
author_facet SHAFAY,Shimaa EL
EL-SHEEKH,Mostafa
BASES,Eman
EL-SHENODY,Rania
author_role author
author2 EL-SHEEKH,Mostafa
BASES,Eman
EL-SHENODY,Rania
author2_role author
author
author
dc.subject.por.fl_str_mv seaweeds
secondary metabolites
antioxidant
antidiabetic
anti-inflammatory
cytotoxicity
anticancer
topic seaweeds
secondary metabolites
antioxidant
antidiabetic
anti-inflammatory
cytotoxicity
anticancer
description Abstract This study aims to evaluate the secondary metabolites, cytotoxicity, antioxidant, antidiabetic, anti-inflammatory, and anticancer activities of four selected seaweeds Padina pavonica, Taonia atomaria, Jania rubens, and Corallina elongata. The maximum value of phenolic content (176.7 ± 6.9 mg gallic acid equivalents/g crude extract) and tannin content (26.5 ± 4.3 mg tannic acid equivalents/g crude extract), was shown in the methanol extract of J. rubens and P. pavonica, respectively. While the ethanol extract of T. atomaria recorded the highest values of total flavonoid content (374.1 ±27.4 mg quercetin equivalents/g crude extract) and total saponins content (30.2 ± 0.7 mg cholesterol equivalents/g crude extract, respectively) compared to other seaweeds. Methanol extract of J. rubens and C. elongata exhibited the greatest content of alkaloids (25.8 ± 4.4 and 22.7 ± 2.6 mg/g d wt.). The methanol extract of P. pavonica established the highest DPPH radical scavenging activity (55.7% ± 0.1) at 50 μg/mL. Among the selected seaweed extracts, the ethanol extract of T. atomaria demonstrated the maximum α-amylase inhibition capacity (66.3% ± 0.0). Methanol extract of J. rubens and P. pavonica species effectively prevented the hypotonicity-induced haemolysis in a concentration-dependent manner compared with the diclofenac potassium as a standard anti-inflammatory drug. In vitro, the reported results also supported the safety and non-toxicity of the four seaweed extracts on WI-38 cell line at lower concentrations. J. rubens and P. pavonica methanol extracts recorded the highest cell growth inhibition of the HeLa Cancer Cell Lines compared to other seaweed extracts and the standard drug Cisplatin.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100698
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100698
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/fst.20521
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
dc.source.none.fl_str_mv Food Science and Technology v.42 2022
reponame:Food Science and Technology (Campinas)
instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron:SBCTA
instname_str Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron_str SBCTA
institution SBCTA
reponame_str Food Science and Technology (Campinas)
collection Food Science and Technology (Campinas)
repository.name.fl_str_mv Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
repository.mail.fl_str_mv ||revista@sbcta.org.br
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score 15,300719

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