Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats

BACKGROUND: Failure of anastomotic healing is one of the major complications in colorectal surgery. Because histamine plays an important role in immune and inflammatory reactions, we demonstrate the effects of famotidine on the healing of colonic anastomosis in rats. METHODS: Twenty-eight Sprague-Da...

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Detalles Bibliográficos
Autores: Inan, Aydin, Sen, Meral, Sürgit, Önder, Ergin, Metin, Bozer, Mikdat
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:Brasil
Institución:Universidade de São Paulo (USP)
Repositorio:Clinics
Idioma:inglés
OAI Identifier:oai:revistas.usp.br:article/18056
Acceso en línea:https://www.revistas.usp.br/clinics/article/view/18056
Access Level:acceso abierto
Palabra clave:Colonic anastomosis
Anastomotic healing
Famotidine
Histamine
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spelling Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats Colonic anastomosisAnastomotic healingFamotidineHistamine BACKGROUND: Failure of anastomotic healing is one of the major complications in colorectal surgery. Because histamine plays an important role in immune and inflammatory reactions, we demonstrate the effects of famotidine on the healing of colonic anastomosis in rats. METHODS: Twenty-eight Sprague-Dawley rats were used in the study. Excision and end-to-end anastomosis was performed in the distal colon of the rat. The Famotidine Group received 2 mg/kg/day famotidine; the Control Group received the same amount of saline. Bursting pressure of anastomoses and hydroxyproline content of perianastomotic tissues were evaluated on the third and seventh days following surgery. RESULTS: Bursting pressures and hydroxyproline contents for the Famotidine Group were significantly lower than the equivalent parameters for the Control Group on both the third and seventh days post-surgery. CONCLUSIONS: According to our findings, famotidine exerts detrimental effects on the anastomotic bursting pressure and hydroxyproline content of perianastomotic tissues in the colon of rats. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1805610.1590/S1807-59322009000600012Clinics; Vol. 64 No. 6 (2009); 567-570 Clinics; v. 64 n. 6 (2009); 567-570 Clinics; Vol. 64 Núm. 6 (2009); 567-570 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18056/20121info:eu-repo/semantics/openAccessInan, AydinSen, MeralSürgit, ÖnderErgin, MetinBozer, Mikdat2012-05-22T18:53:36Zoai:revistas.usp.br:article/18056Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:53:36Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats
title Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats
spellingShingle Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats
Inan, Aydin
Colonic anastomosis
Anastomotic healing
Famotidine
Histamine
title_short Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats
title_full Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats
title_fullStr Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats
title_full_unstemmed Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats
title_sort Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats
dc.creator.none.fl_str_mv Inan, Aydin
Sen, Meral
Sürgit, Önder
Ergin, Metin
Bozer, Mikdat
author Inan, Aydin
author_facet Inan, Aydin
Sen, Meral
Sürgit, Önder
Ergin, Metin
Bozer, Mikdat
author_role author
author2 Sen, Meral
Sürgit, Önder
Ergin, Metin
Bozer, Mikdat
author2_role author
author
author
author
dc.subject.por.fl_str_mv Colonic anastomosis
Anastomotic healing
Famotidine
Histamine
topic Colonic anastomosis
Anastomotic healing
Famotidine
Histamine
description BACKGROUND: Failure of anastomotic healing is one of the major complications in colorectal surgery. Because histamine plays an important role in immune and inflammatory reactions, we demonstrate the effects of famotidine on the healing of colonic anastomosis in rats. METHODS: Twenty-eight Sprague-Dawley rats were used in the study. Excision and end-to-end anastomosis was performed in the distal colon of the rat. The Famotidine Group received 2 mg/kg/day famotidine; the Control Group received the same amount of saline. Bursting pressure of anastomoses and hydroxyproline content of perianastomotic tissues were evaluated on the third and seventh days following surgery. RESULTS: Bursting pressures and hydroxyproline contents for the Famotidine Group were significantly lower than the equivalent parameters for the Control Group on both the third and seventh days post-surgery. CONCLUSIONS: According to our findings, famotidine exerts detrimental effects on the anastomotic bursting pressure and hydroxyproline content of perianastomotic tissues in the colon of rats.
publishDate 2009
dc.date.none.fl_str_mv 2009-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18056
10.1590/S1807-59322009000600012
url https://www.revistas.usp.br/clinics/article/view/18056
identifier_str_mv 10.1590/S1807-59322009000600012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18056/20121
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 64 No. 6 (2009); 567-570
Clinics; v. 64 n. 6 (2009); 567-570
Clinics; Vol. 64 Núm. 6 (2009); 567-570
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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score 15,300719

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