Cytotoxicity analysis of Ti-7.5Mo alloy after biomimetic surface treatment to use as dental materials

Titanium (Ti) and its alloys are widely used for medical and dental fields due to their excellent biocompatibility, high corrosion resistance, high specific strength and excellent mechanical properties. Different methods have been developed to improve the surface properties of titanium-based implant...

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Autores: Do Amaral Escada, Ana Lúcia [UNESP], Camargo, Samira Esteves Afonso [UNESP], De Vasconcellos, Luana Marotta Reis [UNESP], Milhan, Noala Vicensoto Moreira [UNESP], Claro, Ana Paula Rosifini Alves [UNESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/179356
Acceso en línea:http://dx.doi.org/10.1590/1980-5373-MR-2016-0268
http://hdl.handle.net/11449/179356
Access Level:acceso abierto
Palabra clave:Biomimetic treatment
Cytotoxicity
Titanium alloys
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spelling Cytotoxicity analysis of Ti-7.5Mo alloy after biomimetic surface treatment to use as dental materialsBiomimetic treatmentCytotoxicityTitanium alloysTitanium (Ti) and its alloys are widely used for medical and dental fields due to their excellent biocompatibility, high corrosion resistance, high specific strength and excellent mechanical properties. Different methods have been developed to improve the surface properties of titanium-based implant materials, and consequently the bone-bonding ability. The Ti-7.5Mo alloy was activated by an alkaline treatment with 5M NaOH, heat treatment and subsequent immersion in SBFx5 to investigate the in vitro response of osteoblastic-like cells (MG-63) on altered biomimetic surfaces. Sample surfaces were characterized by scanning electron microscopy. Cytotoxicity was assessed by the MTT assay, total protein content, alkaline phosphatase activity (ALP) and mineralized bone-like nodule formation. It was shown the que alkali treatment led to the formation of sodium titanate and immersion in SBFx5 formed a film of calcium phosphate. The alkaline treatment and heat treatment of 7.5 Ti-Mo alloys followed by soaking them in SBFx5 for 24 hours is a suitable technique once the final samples were biocompatible, allowed the attachment of the osteoblastic-like cells (MG-G3), and increased the mineralized like-bone nodules formation by these cells.Departamento de Materiais e Tecnologia Universidade Estadual Paulista -UNESP, Av. Dr. Ariberto Pereira da Cunha, 333Departamento de Biociências e Diagnóstico Bucal Universidade Estadual Paulista -UNESPUniversidade Estadual Paulista -UNESPDepartamento de Materiais e Tecnologia Universidade Estadual Paulista -UNESP, Av. Dr. Ariberto Pereira da Cunha, 333Departamento de Biociências e Diagnóstico Bucal Universidade Estadual Paulista -UNESPUniversidade Estadual Paulista -UNESPUniversidade Estadual Paulista (Unesp)2018-12-11T17:34:51Z2018-12-11T17:34:51Z2017-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1614-1621application/pdfhttp://dx.doi.org/10.1590/1980-5373-MR-2016-0268Materials Research, v. 20, n. 6, p. 1614-1621, 2017.1516-1439http://hdl.handle.net/11449/17935610.1590/1980-5373-MR-2016-0268S1516-143920170006016142-s2.0-85033707015S1516-14392017000601614.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials Research0,398info:eu-repo/semantics/openAccessDo Amaral Escada, Ana Lúcia [UNESP]Camargo, Samira Esteves Afonso [UNESP]De Vasconcellos, Luana Marotta Reis [UNESP]Milhan, Noala Vicensoto Moreira [UNESP]Claro, Ana Paula Rosifini Alves [UNESP]2025-11-12T05:02:06Zoai:repositorio.unesp.br:11449/179356Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-11-12T05:02:06Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cytotoxicity analysis of Ti-7.5Mo alloy after biomimetic surface treatment to use as dental materials
title Cytotoxicity analysis of Ti-7.5Mo alloy after biomimetic surface treatment to use as dental materials
spellingShingle Cytotoxicity analysis of Ti-7.5Mo alloy after biomimetic surface treatment to use as dental materials
Do Amaral Escada, Ana Lúcia [UNESP]
Biomimetic treatment
Cytotoxicity
Titanium alloys
title_short Cytotoxicity analysis of Ti-7.5Mo alloy after biomimetic surface treatment to use as dental materials
title_full Cytotoxicity analysis of Ti-7.5Mo alloy after biomimetic surface treatment to use as dental materials
title_fullStr Cytotoxicity analysis of Ti-7.5Mo alloy after biomimetic surface treatment to use as dental materials
title_full_unstemmed Cytotoxicity analysis of Ti-7.5Mo alloy after biomimetic surface treatment to use as dental materials
title_sort Cytotoxicity analysis of Ti-7.5Mo alloy after biomimetic surface treatment to use as dental materials
dc.creator.none.fl_str_mv Do Amaral Escada, Ana Lúcia [UNESP]
Camargo, Samira Esteves Afonso [UNESP]
De Vasconcellos, Luana Marotta Reis [UNESP]
Milhan, Noala Vicensoto Moreira [UNESP]
Claro, Ana Paula Rosifini Alves [UNESP]
author Do Amaral Escada, Ana Lúcia [UNESP]
author_facet Do Amaral Escada, Ana Lúcia [UNESP]
Camargo, Samira Esteves Afonso [UNESP]
De Vasconcellos, Luana Marotta Reis [UNESP]
Milhan, Noala Vicensoto Moreira [UNESP]
Claro, Ana Paula Rosifini Alves [UNESP]
author_role author
author2 Camargo, Samira Esteves Afonso [UNESP]
De Vasconcellos, Luana Marotta Reis [UNESP]
Milhan, Noala Vicensoto Moreira [UNESP]
Claro, Ana Paula Rosifini Alves [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.subject.por.fl_str_mv Biomimetic treatment
Cytotoxicity
Titanium alloys
topic Biomimetic treatment
Cytotoxicity
Titanium alloys
description Titanium (Ti) and its alloys are widely used for medical and dental fields due to their excellent biocompatibility, high corrosion resistance, high specific strength and excellent mechanical properties. Different methods have been developed to improve the surface properties of titanium-based implant materials, and consequently the bone-bonding ability. The Ti-7.5Mo alloy was activated by an alkaline treatment with 5M NaOH, heat treatment and subsequent immersion in SBFx5 to investigate the in vitro response of osteoblastic-like cells (MG-63) on altered biomimetic surfaces. Sample surfaces were characterized by scanning electron microscopy. Cytotoxicity was assessed by the MTT assay, total protein content, alkaline phosphatase activity (ALP) and mineralized bone-like nodule formation. It was shown the que alkali treatment led to the formation of sodium titanate and immersion in SBFx5 formed a film of calcium phosphate. The alkaline treatment and heat treatment of 7.5 Ti-Mo alloys followed by soaking them in SBFx5 for 24 hours is a suitable technique once the final samples were biocompatible, allowed the attachment of the osteoblastic-like cells (MG-G3), and increased the mineralized like-bone nodules formation by these cells.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-01
2018-12-11T17:34:51Z
2018-12-11T17:34:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1980-5373-MR-2016-0268
Materials Research, v. 20, n. 6, p. 1614-1621, 2017.
1516-1439
http://hdl.handle.net/11449/179356
10.1590/1980-5373-MR-2016-0268
S1516-14392017000601614
2-s2.0-85033707015
S1516-14392017000601614.pdf
url http://dx.doi.org/10.1590/1980-5373-MR-2016-0268
http://hdl.handle.net/11449/179356
identifier_str_mv Materials Research, v. 20, n. 6, p. 1614-1621, 2017.
1516-1439
10.1590/1980-5373-MR-2016-0268
S1516-14392017000601614
2-s2.0-85033707015
S1516-14392017000601614.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Materials Research
0,398
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1614-1621
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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