Associação clonidina-bupivacaína na anestesia peridural caudal para cirurgia de hipospádia em crianças: estudo prospectivo, randomizado, encoberto
The combination of clonidine with local anesthetic administered for epidural anesthesia via caudal route seems to improve the quality of postoperative analgesia, but with conflicting results. This study compared the postoperative analgesia of three different doses of clonidine combined with bupivaca...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | Brasil |
| Institución: | Universidade Federal de Minas Gerais (UFMG) |
| Repositorio: | Repositório Institucional da UFMG |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.ufmg.br:1843/39674 |
| Acceso en línea: | https://doi.org/10.1016/j.bjan.2018.09.008 http://hdl.handle.net/1843/39674 |
| Access Level: | acceso abierto |
| Palabra clave: | Dor pós‐operatória Anestesia peridural caudal Analgesia Bupivacaína Clonidina Dor pós-operatória Bupivacaina Anestesia |
| Sumario: | The combination of clonidine with local anesthetic administered for epidural anesthesia via caudal route seems to improve the quality of postoperative analgesia, but with conflicting results. This study compared the postoperative analgesia of three different doses of clonidine combined with bupivacaine in caudal epidural anesthesia in children undergoing hypospadias repair.Eighty children aged 1 to 10 years, candidates for surgical repair of hypospadias, were randomly divided into four groups of 20 patients to receive general anesthesia combined with caudal epidural anesthesia with bupivacaine 0.165% alone or in combination with 1, 2 or 3 μg.kg‐1 of clonidine. The primary outcome was morphine consumption in the first 24 hours postoperatively. Mean arterial pressure, heart rate, end‐tidal concentration of sevoflurane, time to awakening, pain severity (FLACC scale), level of sedation (RAMSAY), duration of analgesia, and occurrence of adverse effects were also compared. Intraoperatively, there was no difference between groups regarding mean arterial pressure, heart rate, end‐tidal concentration of sevoflurane, and time to awakening. Postoperative morphine consumption and pain severity were similar between groups, but the group receiving clonidine (3 μg.kg‐1) had lower heart rate and higher sedation level than the group receiving bupivacaine alone. The combination of clonidine at doses of 1, 2 or 3 μg.kg‐1 with bupivacaine 0.16% via caudal epidural route did not alter the consumption of morphine in the early postoperative period of children undergoing hypospadias repair. |
|---|