Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation

This study aimed to improve the water solubility of amiodarone hydrochloride (AMH) via inclusion complexes with β-cyclodextrin, methyl-β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin. Inclusion complexes were developed by physical mixture, coevaporation, spray-drying and freeze-drying. Solid state...

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Detalles Bibliográficos
Autores: Rubim, Alexandre Machado, Rubenick, Jaqueline Bandeira, Maurer, Marcela, Laporta, Luciane Varini, Rolim, Clarice Madalena Bueno
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Brasil
Institución:Universidade de São Paulo (USP)
Repositorio:Brazilian Journal of Pharmaceutical Sciences
Idioma:inglés
OAI Identifier:oai:revistas.usp.br:article/134152
Acceso en línea:https://www.revistas.usp.br/bjps/article/view/134152
Access Level:acceso abierto
Palabra clave:Amiodarone HCl/evaluation
Amiodarone HCl/solubility
Cyclodextrins/inclusion complexes
Cyclodextrins /thermodynamic studies
Dissolution rate
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repository_id_str
spelling Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluationAmiodarone HCl/evaluationAmiodarone HCl/solubilityCyclodextrins/inclusion complexesCyclodextrins /thermodynamic studiesDissolution rate This study aimed to improve the water solubility of amiodarone hydrochloride (AMH) via inclusion complexes with β-cyclodextrin, methyl-β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin. Inclusion complexes were developed by physical mixture, coevaporation, spray-drying and freeze-drying. Solid state analysis was performed using X-ray powder diffraction, differential scanning calorimetry and scanning electronic microscopy. Thermodynamic studies demonstrate that the inclusion complexes of drug into different cyclodextrins were an exothermic process that occurred spontaneously. Water solubility and drug dissolution rates were significantly increased after the formation of inclusion complexes with the cyclodextrins evaluated in relation to the physical mixture and pure drug. The present study provides useful information for the potential application of complexation with amiodarone HCl. This may be a good strategy for the development of solid pharmaceutical dosage forms.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/13415210.1590/s2175-97902017000216083Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 2 (2017); e16083-Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 2 (2017); e16083-Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 2 (2017); e16083-2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/134152/129970Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessRubim, Alexandre MachadoRubenick, Jaqueline BandeiraMaurer, MarcelaLaporta, Luciane VariniRolim, Clarice Madalena Bueno2017-06-29T17:40:27Zoai:revistas.usp.br:article/134152Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2017-06-29T17:40:27Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation
title Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation
spellingShingle Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation
Rubim, Alexandre Machado
Amiodarone HCl/evaluation
Amiodarone HCl/solubility
Cyclodextrins/inclusion complexes
Cyclodextrins /thermodynamic studies
Dissolution rate
title_short Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation
title_full Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation
title_fullStr Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation
title_full_unstemmed Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation
title_sort Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation
dc.creator.none.fl_str_mv Rubim, Alexandre Machado
Rubenick, Jaqueline Bandeira
Maurer, Marcela
Laporta, Luciane Varini
Rolim, Clarice Madalena Bueno
author Rubim, Alexandre Machado
author_facet Rubim, Alexandre Machado
Rubenick, Jaqueline Bandeira
Maurer, Marcela
Laporta, Luciane Varini
Rolim, Clarice Madalena Bueno
author_role author
author2 Rubenick, Jaqueline Bandeira
Maurer, Marcela
Laporta, Luciane Varini
Rolim, Clarice Madalena Bueno
author2_role author
author
author
author
dc.subject.por.fl_str_mv Amiodarone HCl/evaluation
Amiodarone HCl/solubility
Cyclodextrins/inclusion complexes
Cyclodextrins /thermodynamic studies
Dissolution rate
topic Amiodarone HCl/evaluation
Amiodarone HCl/solubility
Cyclodextrins/inclusion complexes
Cyclodextrins /thermodynamic studies
Dissolution rate
description This study aimed to improve the water solubility of amiodarone hydrochloride (AMH) via inclusion complexes with β-cyclodextrin, methyl-β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin. Inclusion complexes were developed by physical mixture, coevaporation, spray-drying and freeze-drying. Solid state analysis was performed using X-ray powder diffraction, differential scanning calorimetry and scanning electronic microscopy. Thermodynamic studies demonstrate that the inclusion complexes of drug into different cyclodextrins were an exothermic process that occurred spontaneously. Water solubility and drug dissolution rates were significantly increased after the formation of inclusion complexes with the cyclodextrins evaluated in relation to the physical mixture and pure drug. The present study provides useful information for the potential application of complexation with amiodarone HCl. This may be a good strategy for the development of solid pharmaceutical dosage forms.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/134152
10.1590/s2175-97902017000216083
url https://www.revistas.usp.br/bjps/article/view/134152
identifier_str_mv 10.1590/s2175-97902017000216083
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/134152/129970
dc.rights.driver.fl_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 2 (2017); e16083-
Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 2 (2017); e16083-
Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 2 (2017); e16083-
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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score 15,300719

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