Gut microbiota-skin axis: a systematic review of healthy aging
Introduction: Increasing evidence points to the important relationship between the skin microbiota and its connection with the gut, and vice versa, known as the gut-skin axis, and its anti-aging effects. Integrating the "genome-microbiome-exosome" plays a significant role in aging and skin...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | Brasil |
| Institución: | Faculdade de Medicina em São José do Rio Preto (Faceres) |
| Repositorio: | MedNEXT Journal of Medical and Health Sciences |
| Idioma: | inglés |
| OAI Identifier: | oai:ojs2.mednext.zotarellifilhoscientificworks.com:article/417 |
| Acceso en línea: | https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/417 |
| Access Level: | acceso abierto |
| Palabra clave: | Healthy skin Gut microbiota Health aging Probiotics |
| Sumario: | Introduction: Increasing evidence points to the important relationship between the skin microbiota and its connection with the gut, and vice versa, known as the gut-skin axis, and its anti-aging effects. Integrating the "genome-microbiome-exosome" plays a significant role in aging and skin health. Probiotic-based products are mainly available for the complementary treatment of many dermatological conditions. Objective: It was to analyze, through a systematic review, the main anti-aging nutrological aspects of the gut microbiota-skin axis. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from July to September 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 231 articles were found. A total of 57 articles were evaluated in full and 31 articles were included. According to the GRADE instrument, most studies presented homogeneity in their results, with X2=90.7%>50%. The management of healthy skin is related to the manipulation of intestinal function through functional nutrition, probiotics, and prebiotics. Treatments that enhance or repair a leaky gut barrier may become important as adjunctive therapy in the management of inflammatory skin conditions and may help to increase the effectiveness of standard dermal therapy as well as promote tissue regeneration to mitigate skin aging. All of this would be aimed at modifying the secretory, metabolic and hormonal activity of the intestinal epithelium to positively impact the dermal treatment. |
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