Immunohistochemical expression of PCNA, p53 and bcl-2 in pleomorphic adenomas
The aim of the study was to determine the immunohistochemical expression of the PCNA, p53 and bcl-2 proteins in pleomorphic adenomas. Nineteen specimens of pleomorphic adenomas were selected for analysis by the streptavidin-biotin-peroxidase method with antibodies against p53, PCNA and bcl-2 protein...
| Autores: | , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2008 |
| País: | Brasil |
| Recursos: | Universidade Federal do Rio Grande do Norte (UFRN) |
| Repositório: | Repositório Institucional da UFRN |
| Idioma: | inglês |
| OAI Identifier: | oai:repositorio.ufrn.br:123456789/23856 |
| Acesso em linha: | https://repositorio.ufrn.br/jspui/handle/123456789/23856 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Pleomorphic adenoma Salivary gland tumour p53 PCNA bcl-2 |
| Resumo: | The aim of the study was to determine the immunohistochemical expression of the PCNA, p53 and bcl-2 proteins in pleomorphic adenomas. Nineteen specimens of pleomorphic adenomas were selected for analysis by the streptavidin-biotin-peroxidase method with antibodies against p53, PCNA and bcl-2 proteins. It was observed weak labeling for p53 in 12 cases (63.1%) and for PCNA in 8 (42.1%). With respect to the bcl-2 labeling index, no expression of this protein was detected in 12 cases, corresponding to 63.1% of the sample. Based on these findings, it was concluded that p53 and PCNA can favor the proliferative activity of pleomorphic adenomas, whereas bcl-2 probably does not effectively participate in the pathogenesis of this tumor. |
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