Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression

Type 1 diabetes mellitus (T1D) is an autoimmune disease characterized by beta cell destruction, associated with cellular infiltration and inflammatory responses in the islets of Langerhans. The cellular components of this infiltrate include monocytes, macrophages, CD4+ and CD8+ T cells, and the bala...

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Detalhes bibliográficos
Autor: Karina Braga Gomes Borges
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Brasil
Recursos:Universidade Federal de Minas Gerais (UFMG)
Repositorio:Repositório Institucional da UFMG
Idioma:inglés
OAI Identifier:oai:repositorio.ufmg.br:1843/36787
Acesso em linha:http://hdl.handle.net/1843/36787
Access Level:acceso abierto
Palavra-chave:Type 1 diabetes mellitus
IL-6
Diabetes mellitus tipo 1
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spelling Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expressionType 1 diabetes mellitusIL-6Diabetes mellitus tipo 1Type 1 diabetes mellitus (T1D) is an autoimmune disease characterized by beta cell destruction, associated with cellular infiltration and inflammatory responses in the islets of Langerhans. The cellular components of this infiltrate include monocytes, macrophages, CD4+ and CD8+ T cells, and the balance between Th1 and Th2 cells is crucial in the pathogenesis of this disease. Cytokines play important role in the development and activation of immune cells, since they act as cell-signaling molecules, especially in autoimmune diseases, including T1D. Moreover, cytokines may serve as additional biomarkers of T1D. Cytokines may also provide valuable information about the pathways involved in the regulation of T1D processes. Interleukin-6 (IL-6), a multifunctional cytokine, is secreted by T cells and macrophages to stimulate immune response during inflammation and infection. Indeed, this cytokine is involved in the inflammatory response associated with insulin-resistant states.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoUniversidade Federal de Minas GeraisBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASUFMG2021-07-19T22:12:13Z2021-07-19T22:12:13Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdf10.21037/atm.2016.12.7423055839http://hdl.handle.net/1843/36787engAnnals of Translational Medicineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGKarina Braga Gomes Borges2021-07-19T22:12:13Zoai:repositorio.ufmg.br:1843/36787Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2021-07-19T22:12:13Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression
title Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression
spellingShingle Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression
Karina Braga Gomes Borges
Type 1 diabetes mellitus
IL-6
Diabetes mellitus tipo 1
title_short Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression
title_full Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression
title_fullStr Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression
title_full_unstemmed Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression
title_sort Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression
dc.creator.none.fl_str_mv Karina Braga Gomes Borges
author Karina Braga Gomes Borges
author_facet Karina Braga Gomes Borges
author_role author
dc.subject.por.fl_str_mv Type 1 diabetes mellitus
IL-6
Diabetes mellitus tipo 1
topic Type 1 diabetes mellitus
IL-6
Diabetes mellitus tipo 1
description Type 1 diabetes mellitus (T1D) is an autoimmune disease characterized by beta cell destruction, associated with cellular infiltration and inflammatory responses in the islets of Langerhans. The cellular components of this infiltrate include monocytes, macrophages, CD4+ and CD8+ T cells, and the balance between Th1 and Th2 cells is crucial in the pathogenesis of this disease. Cytokines play important role in the development and activation of immune cells, since they act as cell-signaling molecules, especially in autoimmune diseases, including T1D. Moreover, cytokines may serve as additional biomarkers of T1D. Cytokines may also provide valuable information about the pathways involved in the regulation of T1D processes. Interleukin-6 (IL-6), a multifunctional cytokine, is secreted by T cells and macrophages to stimulate immune response during inflammation and infection. Indeed, this cytokine is involved in the inflammatory response associated with insulin-resistant states.
publishDate 2017
dc.date.none.fl_str_mv 2017
2021-07-19T22:12:13Z
2021-07-19T22:12:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv 10.21037/atm.2016.12.74
23055839
http://hdl.handle.net/1843/36787
identifier_str_mv 10.21037/atm.2016.12.74
23055839
url http://hdl.handle.net/1843/36787
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Annals of Translational Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
UFMG
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
UFMG
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv repositorio@ufmg.br
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score 15,301603

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