Functional recovery caused by human adipose tissue mesenchymal stem cell-derived extracellular vesicles administered 24 h after stroke in rats

Ischemic stroke is a major cause of death and disability, intensely demanding innovative and accessible therapeutic strategies. Approaches presenting a prolonged period for therapeutic intervention and new treatment administration routes are promising tools for stroke treatment. Here, we evaluated t...

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Detalles Bibliográficos
Autores: Rohden, Francieli, Teixeira, Luciele Varaschini, Bernardi, Luis Pedro, Ferreira, Pâmela Cristina Lukasewicz, Colombo, Mariana, Teixeira, Geciéle Rodrigues, Oliveira, Fernanda dos Santos de, Lima, Elizabeth Obino Cirne, Guma, Fátima Theresinha Costa Rodrigues, Souza, Diogo Onofre Gomes de
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Brasil
Institución:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/237125
Acceso en línea:http://hdl.handle.net/10183/237125
Access Level:acceso abierto
Palabra clave:Células-tronco mesenquimais
Vesículas extracelulares
Acidente vascular cerebral
Administração intranasal
Recuperação de função fisiológica
Modelos animais de doenças
Human adipose tissue mesenchymal stem cells
Extracellular vesicles
Experimental ischemic stroke
Intranasal treatment
Neuroprotection
Functional recovery
Descripción
Sumario:Ischemic stroke is a major cause of death and disability, intensely demanding innovative and accessible therapeutic strategies. Approaches presenting a prolonged period for therapeutic intervention and new treatment administration routes are promising tools for stroke treatment. Here, we evaluated the potential neuroprotective properties of nasally administered human adipose tissue mesenchymal stem cell (hAT-MSC)-derived extracellular vesicles (EVs) obtained from healthy individuals who underwent liposuction. After a single intranasal EV (200 µg/kg) administered 24 h after a focal permanent ischemic stroke in rats, a higher number of EVs, improvement of the blood–brain barrier, and re-stabilization of vascularization were observed in the recoverable peri-infarct zone, as well as a significant decrease in infarct volume. In addition, EV treatment recovered long-term motor (front paws symmetry) and behavioral impairment (short- and long-term memory and anxiety-like behavior) induced by ischemic stroke. In line with these findings, our work highlights hAT-MSC-derived EVs as a promising therapeutic strategy for stroke.

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