Atividade antibacteriana de novas 2-Amino-1,4-Naftoquinonas

Vários compostos que possuem esqueleto de 1,4-naftoquinona são amplamente estudados, principalmente no desenvolvimento de novos fármacos. Sua atividade biológica é atribuída à sua capacidade de atuar no transporte de elétrons e, a partir da geração de espécies reativas de oxigênio (ROS) como peróxid...

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Authors: Silva, Carla Cristina da, Paiva, Rojane de Oliveira, Costa, Gisela Lara da, Echevarria, Aurea
Format: article
Status:Published version
Publication Date:2021
Country:Brasil
Institution:Fundação Oswaldo Cruz (FIOCRUZ)
Repository:Repositório Institucional da FIOCRUZ (ARCA)
Language:Portuguese
OAI Identifier:oai:arca.fiocruz.br:icict/49288
Online Access:https://arca.fiocruz.br/handle/icict/49288
Access Level:Open access
Keyword:Naftoquinonas
Atividade antibacteriana
Naphthoquinones
Antibacterial Activity
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repository_id_str
dc.title.none.fl_str_mv Atividade antibacteriana de novas 2-Amino-1,4-Naftoquinonas
dc.title.alternative.none.fl_str_mv Anti-bacterial activity of new 2-Amino-1,4-Naphthoquinones
title Atividade antibacteriana de novas 2-Amino-1,4-Naftoquinonas
spellingShingle Atividade antibacteriana de novas 2-Amino-1,4-Naftoquinonas
Silva, Carla Cristina da
Naftoquinonas
Atividade antibacteriana
Naphthoquinones
Antibacterial Activity
title_short Atividade antibacteriana de novas 2-Amino-1,4-Naftoquinonas
title_full Atividade antibacteriana de novas 2-Amino-1,4-Naftoquinonas
title_fullStr Atividade antibacteriana de novas 2-Amino-1,4-Naftoquinonas
title_full_unstemmed Atividade antibacteriana de novas 2-Amino-1,4-Naftoquinonas
title_sort Atividade antibacteriana de novas 2-Amino-1,4-Naftoquinonas
dc.creator.none.fl_str_mv Silva, Carla Cristina da
Paiva, Rojane de Oliveira
Costa, Gisela Lara da
Echevarria, Aurea
author Silva, Carla Cristina da
author_facet Silva, Carla Cristina da
Paiva, Rojane de Oliveira
Costa, Gisela Lara da
Echevarria, Aurea
author_role author
author2 Paiva, Rojane de Oliveira
Costa, Gisela Lara da
Echevarria, Aurea
author2_role author
author
author
dc.subject.other.none.fl_str_mv Naftoquinonas
Atividade antibacteriana
topic Naftoquinonas
Atividade antibacteriana
Naphthoquinones
Antibacterial Activity
dc.subject.en.none.fl_str_mv Naphthoquinones
Antibacterial Activity
description Vários compostos que possuem esqueleto de 1,4-naftoquinona são amplamente estudados, principalmente no desenvolvimento de novos fármacos. Sua atividade biológica é atribuída à sua capacidade de atuar no transporte de elétrons e, a partir da geração de espécies reativas de oxigênio (ROS) como peróxido de hidrogênio, radicais hidroxila e ânions radicais superóxidos, induzem estresse oxidativo nas células. Este processo é irreversível, pois causa danos permanentes aos ácidos nucléicos e proteínas essenciais. Além disso, a incorporação do átomo de N em C-2 e C-3 da estrutura de 1,4-naftoquinona levou a compostos com atividades biológicas diversificadas, incluindo a antibacteriana. Neste trabalho uma série de 2-amino-1,4-naftoquinonas foi sintetizada e sua atividade antibacteriana foi avaliada contra nove cepas bacterianas incluindo Gram-positivas e Gram-negativas.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-10-06T10:37:16Z
dc.date.available.fl_str_mv 2021-10-06T10:37:16Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Carla Cristina da et al. Atividade antibacteriana de novas 2-Amino-1,4-Naftoquinonas. Brazilian Journal of Development, Curitiba, v. 7, n. 6, p. 54215-54229, jun. 2021.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/49288
dc.identifier.issn.none.fl_str_mv 2525-8761
dc.identifier.doi.none.fl_str_mv 10.34117/bjdv7n6-020
identifier_str_mv SILVA, Carla Cristina da et al. Atividade antibacteriana de novas 2-Amino-1,4-Naftoquinonas. Brazilian Journal of Development, Curitiba, v. 7, n. 6, p. 54215-54229, jun. 2021.
2525-8761
10.34117/bjdv7n6-020
url https://arca.fiocruz.br/handle/icict/49288
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Periódicos e Editora
publisher.none.fl_str_mv Periódicos e Editora
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2021-10-06T10:37:16Z2021-10-06T10:37:16Z2021SILVA, Carla Cristina da et al. Atividade antibacteriana de novas 2-Amino-1,4-Naftoquinonas. Brazilian Journal of Development, Curitiba, v. 7, n. 6, p. 54215-54229, jun. 2021.2525-8761https://arca.fiocruz.br/handle/icict/4928810.34117/bjdv7n6-020Vários compostos que possuem esqueleto de 1,4-naftoquinona são amplamente estudados, principalmente no desenvolvimento de novos fármacos. Sua atividade biológica é atribuída à sua capacidade de atuar no transporte de elétrons e, a partir da geração de espécies reativas de oxigênio (ROS) como peróxido de hidrogênio, radicais hidroxila e ânions radicais superóxidos, induzem estresse oxidativo nas células. Este processo é irreversível, pois causa danos permanentes aos ácidos nucléicos e proteínas essenciais. Além disso, a incorporação do átomo de N em C-2 e C-3 da estrutura de 1,4-naftoquinona levou a compostos com atividades biológicas diversificadas, incluindo a antibacteriana. Neste trabalho uma série de 2-amino-1,4-naftoquinonas foi sintetizada e sua atividade antibacteriana foi avaliada contra nove cepas bacterianas incluindo Gram-positivas e Gram-negativas.Several compounds that have 1,4-naphthoquinone skeleton are widely studied, mainly in the development of new drugs. Its biological activity is attributed to its ability to act in the transport of electrons and, from the generation of reactive oxygen species (ROS) such as hydrogen peroxide, hydroxyl radicals and superoxide radical anions, induce oxidative stress in cells. This process is irreversible as it causes permanent damage to nucleic acids and essential proteins. Moreover, the incorporation of N-atom on C-2 and C-3 of 1,4-naphtoquinone structure has led to compounds with diversified biological activities including the antibacterial. In this work, a series of 2-amino-1,4-naphthoquinones were synthesized, and their antibacterial activity was evaluated against nine bacterial strains including Gram-positive and Gram-negative.Universidade Federal Rural do Rio de Janeiro. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Insituto Oswaldo Cruz. Laboratório de Taxonomia, Bioquímica e Bioprospecção em Fungos. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Seropédica, RJ, Brasil.porPeriódicos e EditoraNaftoquinonasAtividade antibacterianaNaphthoquinonesAntibacterial ActivityAtividade antibacteriana de novas 2-Amino-1,4-NaftoquinonasAnti-bacterial activity of new 2-Amino-1,4-Naphthoquinonesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZSilva, Carla Cristina daPaiva, Rojane de OliveiraCosta, Gisela Lara daEchevarria, AureaLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/11ba0c3b-fab0-4de9-ae9e-e009952ba787/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALGisela_Lara_etal_IOC_2021.pdfGisela_Lara_etal_IOC_2021.pdfapplication/pdf312510https://arca.fiocruz.br/bitstreams/b7b5f34f-3db1-4df1-a29f-61cdc54ecce4/download06b1e23d8cd9a84f06817e744d688a62MD52trueAnonymousREADTHUMBNAILcapa_page-0001.jpgcapa_page-0001.jpgimage/jpeg1648627https://arca.fiocruz.br/bitstreams/aa623816-4f64-4bb9-96e0-2fb5e651feea/download81b05c3930609f2a6baf160471f6b874MD53falseAnonymousREADGisela_Lara_etal_IOC_2021.pdf.jpgGisela_Lara_etal_IOC_2021.pdf.jpgGenerated Thumbnailimage/jpeg35910https://arca.fiocruz.br/bitstreams/d1e9d618-2fba-4e25-b1af-02ea69cf2147/downloadf79768ce63900723a4321b041653aa05MD511falseAnonymousREADTEXTGisela_Lara_etal_IOC_2021.pdf.txtGisela_Lara_etal_IOC_2021.pdf.txtExtracted texttext/plain31719https://arca.fiocruz.br/bitstreams/5f5eb6ac-b670-4375-98e8-03cb88434061/downloadd2e0f8864b1d19a5091bd596585a3ec1MD510falseAnonymousREADicict/492882025-12-10 16:08:48.226open.accessoai:arca.fiocruz.br:icict/49288https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-10T19:08:48Repositório Institucional da FIOCRUZ (ARCA) - 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