Synthesis, Evaluation of Substituent Effect and Antimicrobial Activities of Substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-one Compounds
A series of ten substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-one compounds were synthesized by Crossed-Aldol condensation of 3-bromo-4-marpholino acetophenone with various substituted and unsubstituted benzaldehydes in presence of sodium hydroxide. The entire ten compounds are...
| Autores: | , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | Brasil |
| Recursos: | Universidade Federal de Mato Grosso do Sul (UFMS) |
| Repositorio: | Orbital - The Electronic Journal of Chemistry (Campo Grande) |
| Idioma: | inglés |
| OAI Identifier: | oai:periodicos.ufms.br:article/16506 |
| Acesso em linha: | https://periodicos.ufms.br/index.php/orbital/article/view/16506 |
| Access Level: | acceso abierto |
| Palavra-chave: | synthesis UV IR NMR spectral correlation analysis substituent effects antimicrobial activities |
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Synthesis, Evaluation of Substituent Effect and Antimicrobial Activities of Substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-one CompoundssynthesisUVIRNMRspectral correlation analysissubstituent effectsantimicrobial activitiesA series of ten substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-one compounds were synthesized by Crossed-Aldol condensation of 3-bromo-4-marpholino acetophenone with various substituted and unsubstituted benzaldehydes in presence of sodium hydroxide. The entire ten compounds are novel and these have been newly synthesized compounds. The synthesized substituted 3-phenylprop-2-en-1-one were characterized by their physical constants and UV, IR, NMR spectral data. These observed UV absorption maximum (λmax nm) value. The group frequencies of infrared absorption (cm-1) of νCO s-cis and s-trans, deformation modes of νCH out of plane and in-plane, νCH=CH out of plane, ν>C=C<out of plane values, 1H chemical shifts (ppm) vinyl protons, 13C chemical shifts (ppm) carbonyl carbons and vinyl carbons values were correlated with various Hammett substituent constants, and Swain-Lupton parameters using single and multi-regression analyses. From the results of statistical analysis, the effects of substituents on the functional group frequencies were studied. The antimicrobial activities of these synthesized substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-ones have been screened using Kirby-Bauer method. DOI: http://dx.doi.org/10.17807/orbital.v9i1.852Instituto de Química, Universidade Federal de Mato Grosso do Sul2017-02-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Articleapplication/pdfhttps://periodicos.ufms.br/index.php/orbital/article/view/16506Orbital: The Electronic Journal of Chemistry; Orbital - Vol. 9 No. 1 - January - March 2017; 1-17Orbital: The Electronic Journal of Chemistry; Orbital - Vol. 9 No. 1 - January - March 2017; 1-171984-6428reponame:Orbital - The Electronic Journal of Chemistry (Campo Grande)instname:Universidade Federal de Mato Grosso do Sul (UFMS)instacron:UFMSenghttps://periodicos.ufms.br/index.php/orbital/article/view/16506/11185Copyright (c) 2017 Orbital: The Electronic Journal of Chemistryhttps://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessBalaji, SelvarajRajarajan, MuruganVijayakumar, RenganathanManikandan, VenkatesanSenbagam, RajamohanVanangamudi, GanesanThirunarayanan, Ganesamoorthy2023-01-20T10:59:57Zoai:periodicos.ufms.br:article/16506Revistahttps://periodicos.ufms.br/index.php/orbital/indexPUBhttps://periodicos.ufms.br/index.php/orbital/oaieditor.orbital@ufms.br || marcos.amaral@ufms.br1984-64281984-6428opendoar:2023-01-20T10:59:57Orbital - The Electronic Journal of Chemistry (Campo Grande) - Universidade Federal de Mato Grosso do Sul (UFMS)false |
| dc.title.none.fl_str_mv |
Synthesis, Evaluation of Substituent Effect and Antimicrobial Activities of Substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-one Compounds |
| title |
Synthesis, Evaluation of Substituent Effect and Antimicrobial Activities of Substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-one Compounds |
| spellingShingle |
Synthesis, Evaluation of Substituent Effect and Antimicrobial Activities of Substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-one Compounds Balaji, Selvaraj synthesis UV IR NMR spectral correlation analysis substituent effects antimicrobial activities |
| title_short |
Synthesis, Evaluation of Substituent Effect and Antimicrobial Activities of Substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-one Compounds |
| title_full |
Synthesis, Evaluation of Substituent Effect and Antimicrobial Activities of Substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-one Compounds |
| title_fullStr |
Synthesis, Evaluation of Substituent Effect and Antimicrobial Activities of Substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-one Compounds |
| title_full_unstemmed |
Synthesis, Evaluation of Substituent Effect and Antimicrobial Activities of Substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-one Compounds |
| title_sort |
Synthesis, Evaluation of Substituent Effect and Antimicrobial Activities of Substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-one Compounds |
| dc.creator.none.fl_str_mv |
Balaji, Selvaraj Rajarajan, Murugan Vijayakumar, Renganathan Manikandan, Venkatesan Senbagam, Rajamohan Vanangamudi, Ganesan Thirunarayanan, Ganesamoorthy |
| author |
Balaji, Selvaraj |
| author_facet |
Balaji, Selvaraj Rajarajan, Murugan Vijayakumar, Renganathan Manikandan, Venkatesan Senbagam, Rajamohan Vanangamudi, Ganesan Thirunarayanan, Ganesamoorthy |
| author_role |
author |
| author2 |
Rajarajan, Murugan Vijayakumar, Renganathan Manikandan, Venkatesan Senbagam, Rajamohan Vanangamudi, Ganesan Thirunarayanan, Ganesamoorthy |
| author2_role |
author author author author author author |
| dc.subject.por.fl_str_mv |
synthesis UV IR NMR spectral correlation analysis substituent effects antimicrobial activities |
| topic |
synthesis UV IR NMR spectral correlation analysis substituent effects antimicrobial activities |
| description |
A series of ten substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-one compounds were synthesized by Crossed-Aldol condensation of 3-bromo-4-marpholino acetophenone with various substituted and unsubstituted benzaldehydes in presence of sodium hydroxide. The entire ten compounds are novel and these have been newly synthesized compounds. The synthesized substituted 3-phenylprop-2-en-1-one were characterized by their physical constants and UV, IR, NMR spectral data. These observed UV absorption maximum (λmax nm) value. The group frequencies of infrared absorption (cm-1) of νCO s-cis and s-trans, deformation modes of νCH out of plane and in-plane, νCH=CH out of plane, ν>C=C<out of plane values, 1H chemical shifts (ppm) vinyl protons, 13C chemical shifts (ppm) carbonyl carbons and vinyl carbons values were correlated with various Hammett substituent constants, and Swain-Lupton parameters using single and multi-regression analyses. From the results of statistical analysis, the effects of substituents on the functional group frequencies were studied. The antimicrobial activities of these synthesized substituted (E)-1-(3-bromo-4-morpholinophenyl)-3-phenylprop-2-en-1-ones have been screened using Kirby-Bauer method. DOI: http://dx.doi.org/10.17807/orbital.v9i1.852 |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-02-13 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://periodicos.ufms.br/index.php/orbital/article/view/16506 |
| url |
https://periodicos.ufms.br/index.php/orbital/article/view/16506 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://periodicos.ufms.br/index.php/orbital/article/view/16506/11185 |
| dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Orbital: The Electronic Journal of Chemistry https://creativecommons.org/licenses/by-nc-nd/4.0 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Copyright (c) 2017 Orbital: The Electronic Journal of Chemistry https://creativecommons.org/licenses/by-nc-nd/4.0 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Instituto de Química, Universidade Federal de Mato Grosso do Sul |
| publisher.none.fl_str_mv |
Instituto de Química, Universidade Federal de Mato Grosso do Sul |
| dc.source.none.fl_str_mv |
Orbital: The Electronic Journal of Chemistry; Orbital - Vol. 9 No. 1 - January - March 2017; 1-17 Orbital: The Electronic Journal of Chemistry; Orbital - Vol. 9 No. 1 - January - March 2017; 1-17 1984-6428 reponame:Orbital - The Electronic Journal of Chemistry (Campo Grande) instname:Universidade Federal de Mato Grosso do Sul (UFMS) instacron:UFMS |
| instname_str |
Universidade Federal de Mato Grosso do Sul (UFMS) |
| instacron_str |
UFMS |
| institution |
UFMS |
| reponame_str |
Orbital - The Electronic Journal of Chemistry (Campo Grande) |
| collection |
Orbital - The Electronic Journal of Chemistry (Campo Grande) |
| repository.name.fl_str_mv |
Orbital - The Electronic Journal of Chemistry (Campo Grande) - Universidade Federal de Mato Grosso do Sul (UFMS) |
| repository.mail.fl_str_mv |
editor.orbital@ufms.br || marcos.amaral@ufms.br |
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1853664387347251200 |
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15.300724 |