Níveis de interleucinas no líquido peritoneal em pacientes com neoplasias de ovário
INTRODUCTION: Malignant neoplasm of ovary is one of the five most common cancers in women and the leading cause of gynaecological malignancy in developed countries. Ascites is an inflammatory environment rich in mediators of inflammation, and inflammatory cytokines could be used as prognostic factor...
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| Format: | master thesis |
| Status: | Published version |
| Publication Date: | 2018 |
| Country: | Brasil |
| Institution: | Universidade Federal do Triangulo Mineiro (UFTM) |
| Repository: | Biblioteca Digital de Teses e Dissertações da UFTM |
| Language: | Portuguese |
| OAI Identifier: | oai:bdtd.uftm.edu.br:tede/927 |
| Online Access: | http://bdtd.uftm.edu.br/handle/tede/927 |
| Access Level: | Open access |
| Keyword: | IL-6. IL-8. Fatores prognósticos. Câncer de ovário citocinas. Prognosis. Ovarian neoplasms. Cytokines. Ciências da Saúde |
| Summary: | INTRODUCTION: Malignant neoplasm of ovary is one of the five most common cancers in women and the leading cause of gynaecological malignancy in developed countries. Ascites is an inflammatory environment rich in mediators of inflammation, and inflammatory cytokines could be used as prognostic factors. OBJECTIVE: The objectives of the study were to analyze the dosage of a cytokines panel (IL2, IL5, IL6, IL8, IL10 and TNF-α) in the peritoneal fluid and relate the dosage of these cytokines to clinical and clinical prognostic parameters pathologies in ovarian cancer. MATERIAL AND METHODS: We evaluated 117 patients, divided into three groups: non-neoplastic ovarian lesions (n = 14), benign lesions (n = 74), and malignant ovarian lesions (n = 29). We created a database with age, parity, hormonal status, histological type and in the case of malignant tumours, tumour grade, stage (FIGO) and test results of each cytokine analysed in ascites or peritoneal lavage. The results between the groups of non-neoplastic, benign and malignant lesions were compared through the Kruskal-Wallis test with Dunn post-test, cytokines and prognostic factors comparisons was used the Wilcoxon-Mann-Whitney test and considered significant when p <0.05. RESULTS: We evaluated 29 patients with ovarian cancer. Higher levels of IL-6 were related to RNL > 4 (p = 0.0311), RPL > 200 (p = 0.0051), CA-125 levels > 35 U / mL (p = 0.0019), stage IIIC (p = 0.0203), and SLD ≤ 24 months (p = 0.0267). In the evaluation of IL-8, higher levels of this cytokine were related to NLR > 4 (p = 0.0241), RPL > 200 (p = 0.0426), and CA125 > 35U / mL (p = 0.0292). CONCLUSION: IL 6 and IL 8 in the peritoneal lavage were related to poor prognostic factors. The evaluation of these cytokines may lead the oncologist to individualize the adjuvant treatment making it more or less aggressive; depending on the profile of each patient, as well as these cytokines may be the target of new therapies in ovarian cancer. |
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