Evaluation of the toxicity of the medicinal plant Peumus Boldus during the gestational period in Wistar rats / Avaliação da toxicidade da planta medicinal Peumus Boldus durante o período gestacional de ratas Wistar
Medicinal plants are sources of numerous compounds used in the production of drugs to treat a wide variety of symptoms. It is known that Peumus boldus, traditionally known as Boldo, has therapeutic properties applied to several digestive and liver disorders. However, as with all natural extracts, li...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | Brasil |
| Institución: | Instituto Superior de Educação Vera Cruz (VeraCruz) |
| Repositorio: | Revista Veras |
| Idioma: | portugués |
| OAI Identifier: | oai:ojs2.ojs.brazilianjournals.com.br:article/31812 |
| Acceso en línea: | https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/31812 |
| Access Level: | acceso abierto |
| Palabra clave: | Peumus Boldus Histopathology Reproductive Capacity Fetal Vitality Boldus. |
| Sumario: | Medicinal plants are sources of numerous compounds used in the production of drugs to treat a wide variety of symptoms. It is known that Peumus boldus, traditionally known as Boldo, has therapeutic properties applied to several digestive and liver disorders. However, as with all natural extracts, little is known about its effects on pregnancy. The literature suggests abortifacient and teratogenic effects in pregnant animals treated with P. boldus. In this sense, the present study verified the effects of commercial P. boldus extract during the gestational period in Wistar rats. The animals were divided into two groups: Control (n=3; 1 ml of distilled water) and Treated (n=6; 1.7mL/300g/day of P. boldus). Oral administration of distilled water or extract took place on days 1, 5, 10 and 15 of gestation in the rats. After 18 days of gestation, a cesarean section was performed, and the reproductive capacity of the rats and the vitality of the pups were evaluated. The placentas and fetuses were measured, and the fetuses were fixed (24h) in 10% formaldehyde solution for analysis of the anatomical parameters and measurements: anteroposterior of the skull, lateral-lateral of the skull, anteroposterior of the thorax, lateral-lateral of the thorax, craniocaudal and caudal. Other parameters were also evaluated, such as: eye and ear implantation, upper and lower limbs, finger configuration, and anal orifice. Next, the fetuses were dehydrated in increasing ethanol series, clarified in xylene and embedded in paraffin for microtomy (5?m) and stained with hematoxylin and eosin. The tissues of the following organs were observed in the histological analysis: brain, heart, lung, liver and kidney. Reproductive capacity, vitality of the pups, weights of fetuses and placentas and macroscopic analysis of morphological parameters of the pups showed no significant difference when compared to the control group (p>0.05). In the histopathological analysis, there were no significant changes when compared to the control group (p>0.05). Therefore, it was concluded that the commercial extract of P. boldus, at the dose studied, did not induce maternal and reproductive toxicity, since it did not present deleterious effects to the pregnant woman or to the embryo and fetus of the rats exposed to this phytotherapeutic. However, further studies are needed, with higher doses of P. boldus administered over the long term, to ensure its safe use in pregnant women. |
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