Quantitative AgNORs study in ameloblastomas
Purpose: Ameloblastomas are tumors that arise from the odontogenic epithelium, including the areas that coat the dentigerous cysts (DC). The aim of the present study was to investigate the proliferative activity present in luminal and mural areas of mural unicystic ameloblastomas (MUA), in conventio...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2008 |
| País: | Brasil |
| Institución: | Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
| Repositorio: | Revista odonto ciência (Online) |
| Idioma: | inglés |
| OAI Identifier: | oai:ojs.revistaseletronicas.pucrs.br:article/4266 |
| Acceso en línea: | https://revistaseletronicas.pucrs.br/fo/article/view/4266 |
| Access Level: | acceso abierto |
| Palabra clave: | Ameloblastoma AgNOR cell proliferation dentigerous cyst Oral Biology Oral Pathology |
| Sumario: | Purpose: Ameloblastomas are tumors that arise from the odontogenic epithelium, including the areas that coat the dentigerous cysts (DC). The aim of the present study was to investigate the proliferative activity present in luminal and mural areas of mural unicystic ameloblastomas (MUA), in conventional ameloblastomas (CA), and in DC, comparing them according to their biological behavior. Methods: AgNOR quantifications were performed using routine light microscopy under X100 magnification in 10 cases per type of lesion, considering 100 cells of representative areas of the tumor for each case. The AgNORs were observed as black dots within the cell nucleus. Results: MUA showed significant lower number of NORs/nucleus in the luminal proliferation area than in the area of mural proliferation and in CA (P<0.05). Conclusion: CA exhibit proliferative activity similar to the mural component of MUA, corroborating the pattern of higher aggressive clinical behavior of these tumor variants. Key words: Ameloblastoma; AgNOR; cell proliferation; dentigerous cyst |
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