Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan

Attention-Deficit/Hyperactivity Disorder (ADHD) has been associated with altered brain anatomy in neuroimaging studies. However, small and heterogeneous study samples, and the use of region-of-interest and tissuespecific analyses have limited the consistency and replicability of these effects. We us...

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Autores: Cupertino, Renata Basso, Grevet, Eugenio Horácio, Bandeira, Cibele Edom, Picon, Felipe Almeida, Tavares, Maria Eduarda de Araujo, Vitola, Eduardo Schneider, Breda, Vitor Carlos Thumé, Bau, Claiton Henrique Dotto, Sprooten, Emma
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Brasil
Institución:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/217954
Acceso en línea:http://hdl.handle.net/10183/217954
Access Level:acceso abierto
Palabra clave:Transtorno do déficit de atenção com hiperatividade
Substância branca
Neuroimagem
Anatomia
Lobo frontal
Estudos de coortes
ADHD
White matter
Fronto-striatal
Tensor-based morphometry
Independent component analysis
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spelling 2021-02-12T04:07:02Z20202213-1582http://hdl.handle.net/10183/217954001121231Attention-Deficit/Hyperactivity Disorder (ADHD) has been associated with altered brain anatomy in neuroimaging studies. However, small and heterogeneous study samples, and the use of region-of-interest and tissuespecific analyses have limited the consistency and replicability of these effects. We used a data-driven multivariate approach to investigate neuroanatomical features associated with ADHD in two independent cohorts: the Dutch NeuroIMAGE cohort (n = 890, 17.2 years) and the Brazilian IMpACT cohort (n = 180, 44.2 years). Using independent component analysis of whole-brain morphometry images, 375 neuroanatomical components were assessed for association with ADHD. In both discovery (corrected-p = 0.0085) and replication (p = 0.032) cohorts, ADHD was associated with reduced volume in frontal lobes, striatum, and their interconnecting whitematter. Current results provide further evidence for the role of the fronto-striatal circuit in ADHD in children, and for the first time show its relevance to ADHD in adults. The fact that the cohorts are from different continents and comprise different age ranges highlights the robustness of the findings.application/pdfengNeuroImage. Clinical. [Amsterdam]. Vol. 28 (2020), 102403, p. 1-9Transtorno do déficit de atenção com hiperatividadeSubstância brancaNeuroimagemAnatomiaLobo frontalEstudos de coortesADHDWhite matterFronto-striatalTensor-based morphometryIndependent component analysisReduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespanEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSCupertino, Renata BassoGrevet, Eugenio HorácioBandeira, Cibele EdomPicon, Felipe AlmeidaTavares, Maria Eduarda de AraujoVitola, Eduardo SchneiderBreda, Vitor Carlos ThuméBau, Claiton Henrique DottoSprooten, EmmaTEXT001121231.pdf.txt001121231.pdf.txtExtracted Texttext/plain63265http://www.lume.ufrgs.br/bitstream/10183/217954/2/001121231.pdf.txt99a38a99e9c4095db0273dfec9182c9bMD52ORIGINAL001121231.pdfTexto completo (inglês)application/pdf1372893http://www.lume.ufrgs.br/bitstream/10183/217954/1/001121231.pdfb37db45bee4b4d626f41cb51bc44a6f3MD5110183/2179542023-08-06 03:45:13.035921oai:www.lume.ufrgs.br:10183/217954Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2023-08-06T06:45:13Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan
title Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan
spellingShingle Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan
Cupertino, Renata Basso
Transtorno do déficit de atenção com hiperatividade
Substância branca
Neuroimagem
Anatomia
Lobo frontal
Estudos de coortes
ADHD
White matter
Fronto-striatal
Tensor-based morphometry
Independent component analysis
title_short Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan
title_full Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan
title_fullStr Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan
title_full_unstemmed Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan
title_sort Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan
dc.creator.none.fl_str_mv Cupertino, Renata Basso
Grevet, Eugenio Horácio
Bandeira, Cibele Edom
Picon, Felipe Almeida
Tavares, Maria Eduarda de Araujo
Vitola, Eduardo Schneider
Breda, Vitor Carlos Thumé
Bau, Claiton Henrique Dotto
Sprooten, Emma
author Cupertino, Renata Basso
author_facet Cupertino, Renata Basso
Grevet, Eugenio Horácio
Bandeira, Cibele Edom
Picon, Felipe Almeida
Tavares, Maria Eduarda de Araujo
Vitola, Eduardo Schneider
Breda, Vitor Carlos Thumé
Bau, Claiton Henrique Dotto
Sprooten, Emma
author_role author
author2 Grevet, Eugenio Horácio
Bandeira, Cibele Edom
Picon, Felipe Almeida
Tavares, Maria Eduarda de Araujo
Vitola, Eduardo Schneider
Breda, Vitor Carlos Thumé
Bau, Claiton Henrique Dotto
Sprooten, Emma
author2_role author
author
author
author
author
author
author
author
dc.subject.por.fl_str_mv Transtorno do déficit de atenção com hiperatividade
Substância branca
Neuroimagem
Anatomia
Lobo frontal
Estudos de coortes
topic Transtorno do déficit de atenção com hiperatividade
Substância branca
Neuroimagem
Anatomia
Lobo frontal
Estudos de coortes
ADHD
White matter
Fronto-striatal
Tensor-based morphometry
Independent component analysis
dc.subject.eng.fl_str_mv ADHD
White matter
Fronto-striatal
Tensor-based morphometry
Independent component analysis
description Attention-Deficit/Hyperactivity Disorder (ADHD) has been associated with altered brain anatomy in neuroimaging studies. However, small and heterogeneous study samples, and the use of region-of-interest and tissuespecific analyses have limited the consistency and replicability of these effects. We used a data-driven multivariate approach to investigate neuroanatomical features associated with ADHD in two independent cohorts: the Dutch NeuroIMAGE cohort (n = 890, 17.2 years) and the Brazilian IMpACT cohort (n = 180, 44.2 years). Using independent component analysis of whole-brain morphometry images, 375 neuroanatomical components were assessed for association with ADHD. In both discovery (corrected-p = 0.0085) and replication (p = 0.032) cohorts, ADHD was associated with reduced volume in frontal lobes, striatum, and their interconnecting whitematter. Current results provide further evidence for the role of the fronto-striatal circuit in ADHD in children, and for the first time show its relevance to ADHD in adults. The fact that the cohorts are from different continents and comprise different age ranges highlights the robustness of the findings.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-02-12T04:07:02Z
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/217954
dc.identifier.issn.pt_BR.fl_str_mv 2213-1582
dc.identifier.nrb.pt_BR.fl_str_mv 001121231
identifier_str_mv 2213-1582
001121231
url http://hdl.handle.net/10183/217954
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv NeuroImage. Clinical. [Amsterdam]. Vol. 28 (2020), 102403, p. 1-9
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
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repository.mail.fl_str_mv lume@ufrgs.br
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