Interleukin-8-251T > a, interleukin-1α-889C > t and apolipoprotein e polymorphisms in Alzheimer's disease

An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson's disease, stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located in the vicinity of amyloid plaques. Cytokines, such as interleukin-8 (IL-8) and interleukin...

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Detalles Bibliográficos
Autores: Vendramini, Alex Augusto, Lábio, Roger Willian de, Rasmussen, Lucas Trevizani [UNIFESP], Reis, Nathali Mattiuzo dos [UNIFESP], Minett, Thaís Soares Cianciarullo [UNIFESP], Bertolucci, Paulo Henrique Ferreira [UNIFESP], Pinhel, Marcela Augusta de Souza, Souza, Dorotéia Rossi Silva, Mazzotti, Diego Robles [UNIFESP], Smith, Marilia de Arruda Cardoso [UNIFESP], Payão, Spencer Luiz Marques [UNIFESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:Brasil
Institución:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/6257
Acceso en línea:http://dx.doi.org/10.1590/S1415-47572010005000098
http://repositorio.unifesp.br/handle/11600/6257
Access Level:acceso abierto
Palabra clave:IL-8
IL-1α
Alzheimer's Disease
APOE
inflammatory response
Descripción
Sumario:An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson's disease, stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located in the vicinity of amyloid plaques. Cytokines, such as interleukin-8 (IL-8) and interleukin-1α (IL-1α), have been clearly involved in this inflammatory process. Polymorphisms of several interleukin genes have been correlated to the risk of developing AD. The present study investigated the association of AD with polymorphisms IL-8 -251T > A (rs4073) and IL-1α-889C > T (rs1800587) and the interactive effect of both, adjusted by the Apolipoprotein E genotype. 199 blood samples from patients with AD, 146 healthy elderly controls and 95 healthy young controls were obtained. DNA samples were isolated from blood cells, and the PCR-RFLP method was used for genotyping. The genotype distributions of polymorphisms IL-8, IL-1α and APOE were as expected under Hardy-Weinberg equilibrium. The allele frequencies did not differ significantly among the three groups tested. As expected, the APOE4 allele was strongly associated with AD (p < 0.001). No association of AD with either the IL-1α or the IL-8 polymorphism was observed, nor was any interactive effect between both polymorphisms. These results confirm previous studies in other populations, in which polymorphisms IL-8 -251T > A and IL-1α-889C > T were not found to be risk factors for AD.

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