Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives

Novel series of heterocyclic compounds 2-aryl-1-(4-(naphthalen-2-yl)thiazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid derivatives (4a–h) and 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl) pyrrolidin-2-one derivatives (5a–h) have been synthesized by condensation of Schiff base...

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Detalhes bibliográficos
Autores: Patel, Kandarp H., Patel, Yogesh S.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Brasil
Recursos:Universidade Federal de Mato Grosso do Sul (UFMS)
Repositorio:Orbital - The Electronic Journal of Chemistry (Campo Grande)
Idioma:inglés
OAI Identifier:oai:periodicos.ufms.br:article/17865
Acesso em linha:https://periodicos.ufms.br/index.php/orbital/article/view/17865
Access Level:acceso abierto
Palavra-chave:heterocyclic compounds
thiazole
benzimidazole
pyrrolidin-2-one
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spelling Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivativesheterocyclic compoundsthiazolebenzimidazolepyrrolidin-2-oneNovel series of heterocyclic compounds 2-aryl-1-(4-(naphthalen-2-yl)thiazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid derivatives (4a–h) and 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl) pyrrolidin-2-one derivatives (5a–h) have been synthesized by condensation of Schiff bases arylidine-[4-(2-naphthalenyl)thiazolyl]-2-amines (3a–h) with succinic anhydride. Synthesized heterocyclic compounds were duly characterized by physico chemical parameters, 1H-NMR, 13C-NMR and FT–IR spectral features. Schiff bases 3a–h have been synthesized from 4-(naphthalen-2-yl)thiazol-2-amine 1 and various aromatic aldehydes 2a–h. All novel synthesized compounds 4a–h and 5a–h were evaluated for their antibacterial activity against various Gram positive bacterial strains e.g. Bacillus subtilis [BS] and Staphylococcus aureus [SA] and Gram negative bacterial strains e.g. Salmonella typhimurium [ST] and Escherichia coli [EC]. Growth inhibition was compared with the standard drug ciprofloxacin. Antifungal activity was also carried out against different fungal strains e.g. Penicillium expansum [PE], Botryodiplodia theobromae [BT], Nigrospora sp. [NS], Trichothesium sp. [TS]. The antifungal drug, Ketoconazole was used as a positive control. Compounds 4a–h found less active as compare to compound 5a–h. DOI: http://dx.doi.org/10.17807/orbital.v7i3.723  Instituto de Química, Universidade Federal de Mato Grosso do Sul2015-09-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Articleapplication/pdfhttps://periodicos.ufms.br/index.php/orbital/article/view/17865Orbital: The Electronic Journal of Chemistry; Orbital - Vol. 7 No. 3 - July-September 2015; 231-239Orbital: The Electronic Journal of Chemistry; Orbital - Vol. 7 No. 3 - July-September 2015; 231-2391984-6428reponame:Orbital - The Electronic Journal of Chemistry (Campo Grande)instname:Universidade Federal de Mato Grosso do Sul (UFMS)instacron:UFMSenghttps://periodicos.ufms.br/index.php/orbital/article/view/17865/12258Copyright (c) 2015 Orbital: The Electronic Journal of Chemistryhttps://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessPatel, Kandarp H.Patel, Yogesh S.2023-01-20T11:04:02Zoai:periodicos.ufms.br:article/17865Revistahttps://periodicos.ufms.br/index.php/orbital/indexPUBhttps://periodicos.ufms.br/index.php/orbital/oaieditor.orbital@ufms.br || marcos.amaral@ufms.br1984-64281984-6428opendoar:2023-01-20T11:04:02Orbital - The Electronic Journal of Chemistry (Campo Grande) - Universidade Federal de Mato Grosso do Sul (UFMS)false
dc.title.none.fl_str_mv Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives
title Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives
spellingShingle Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives
Patel, Kandarp H.
heterocyclic compounds
thiazole
benzimidazole
pyrrolidin-2-one
title_short Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives
title_full Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives
title_fullStr Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives
title_full_unstemmed Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives
title_sort Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives
dc.creator.none.fl_str_mv Patel, Kandarp H.
Patel, Yogesh S.
author Patel, Kandarp H.
author_facet Patel, Kandarp H.
Patel, Yogesh S.
author_role author
author2 Patel, Yogesh S.
author2_role author
dc.subject.por.fl_str_mv heterocyclic compounds
thiazole
benzimidazole
pyrrolidin-2-one
topic heterocyclic compounds
thiazole
benzimidazole
pyrrolidin-2-one
description Novel series of heterocyclic compounds 2-aryl-1-(4-(naphthalen-2-yl)thiazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid derivatives (4a–h) and 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl) pyrrolidin-2-one derivatives (5a–h) have been synthesized by condensation of Schiff bases arylidine-[4-(2-naphthalenyl)thiazolyl]-2-amines (3a–h) with succinic anhydride. Synthesized heterocyclic compounds were duly characterized by physico chemical parameters, 1H-NMR, 13C-NMR and FT–IR spectral features. Schiff bases 3a–h have been synthesized from 4-(naphthalen-2-yl)thiazol-2-amine 1 and various aromatic aldehydes 2a–h. All novel synthesized compounds 4a–h and 5a–h were evaluated for their antibacterial activity against various Gram positive bacterial strains e.g. Bacillus subtilis [BS] and Staphylococcus aureus [SA] and Gram negative bacterial strains e.g. Salmonella typhimurium [ST] and Escherichia coli [EC]. Growth inhibition was compared with the standard drug ciprofloxacin. Antifungal activity was also carried out against different fungal strains e.g. Penicillium expansum [PE], Botryodiplodia theobromae [BT], Nigrospora sp. [NS], Trichothesium sp. [TS]. The antifungal drug, Ketoconazole was used as a positive control. Compounds 4a–h found less active as compare to compound 5a–h. DOI: http://dx.doi.org/10.17807/orbital.v7i3.723  
publishDate 2015
dc.date.none.fl_str_mv 2015-09-19
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.ufms.br/index.php/orbital/article/view/17865
url https://periodicos.ufms.br/index.php/orbital/article/view/17865
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicos.ufms.br/index.php/orbital/article/view/17865/12258
dc.rights.driver.fl_str_mv Copyright (c) 2015 Orbital: The Electronic Journal of Chemistry
https://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2015 Orbital: The Electronic Journal of Chemistry
https://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto de Química, Universidade Federal de Mato Grosso do Sul
publisher.none.fl_str_mv Instituto de Química, Universidade Federal de Mato Grosso do Sul
dc.source.none.fl_str_mv Orbital: The Electronic Journal of Chemistry; Orbital - Vol. 7 No. 3 - July-September 2015; 231-239
Orbital: The Electronic Journal of Chemistry; Orbital - Vol. 7 No. 3 - July-September 2015; 231-239
1984-6428
reponame:Orbital - The Electronic Journal of Chemistry (Campo Grande)
instname:Universidade Federal de Mato Grosso do Sul (UFMS)
instacron:UFMS
instname_str Universidade Federal de Mato Grosso do Sul (UFMS)
instacron_str UFMS
institution UFMS
reponame_str Orbital - The Electronic Journal of Chemistry (Campo Grande)
collection Orbital - The Electronic Journal of Chemistry (Campo Grande)
repository.name.fl_str_mv Orbital - The Electronic Journal of Chemistry (Campo Grande) - Universidade Federal de Mato Grosso do Sul (UFMS)
repository.mail.fl_str_mv editor.orbital@ufms.br || marcos.amaral@ufms.br
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score 15,300719

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