Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition
Aims: To describe the abundance of major phyla and some genera in the gut microbiota of individuals according to dietary habits and examine their associations with inflammatory markers, insulin resistance, and cardiovascular risk profile. Methods: A total of 268 non-diabetic individuals were stratif...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | Brasil |
| Institución: | Universidade Federal de São Paulo (UNIFESP) |
| Repositorio: | Repositório Institucional da UNIFESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unifesp.br:11600/51391 |
| Acceso en línea: | http://dx.doi.org/10.1186/s13098-017-0261-x http://repositorio.unifesp.br/handle/11600/51391 |
| Access Level: | acceso abierto |
| Palabra clave: | Gut microbiota Diet Biomarkers Inflammation Insulin resistance |
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Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota compositionGut microbiotaDietBiomarkersInflammationInsulin resistanceAims: To describe the abundance of major phyla and some genera in the gut microbiota of individuals according to dietary habits and examine their associations with inflammatory markers, insulin resistance, and cardiovascular risk profile. Methods: A total of 268 non-diabetic individuals were stratified into groups of dietary types (strict vegetarians, lacto-ovo-vegetarians, and omnivores). The taxonomic composition and phylogenetic structure of the microbiota were obtained through the analysis of the 16S rRNA gene. Samples were clustered into operational taxonomic units at 97% similarity using GreenGenes 13.5 database. Clinical, biochemical, and circulating inflammatory markers were compared by ANOVA or Kruskal-Wallis test. Results: The sample (54.2% women, mean age 49.5 years) was composed of 66 strict vegetarians, 102 lacto-ovo-vegetarians and 100 omnivores. Considering the entire sample, the greatest abundant phyla were Firmicutes (40.7 +/- 15.9%) and Bacteroidetes (39.5 +/- 19.9%), and no difference in abundances was found between individuals with normal and excess weight. Stratifying by dietary types, the proportion of Firmicutes was lower and of Bacteroidetes was higher in strict vegetarians when compared to lacto-ovo-vegetarians and omnivores. At the genus level, strict vegetarians had a higher Prevotella abundance and Prevotella/Bacteroides ratio than the other groups. They also had a lower proportion of Faecalibacterium than lacto-ovo-vegetarians, and both vegetarian groups had higher proportions than did omnivores. Succinivibrio and Halomonas from the Proteobacteria phylum were overrepresented in omnivores. The omnivorous group showed higher values of anthropometric data, insulin, HOMA-IR, and a worse lipid profile. Inflammatory markers exhibited a gradual and significant increase from the vegetarians and lacto-ovo-vegetarians to the omnivorous group. Conclusions: There are differences in gut microbiota composition of individuals with distinct dietary habits, who differ according to their inflammatory and metabolic profiles. Based on the findings relative to bacteria abundances and on their recognized actions in the metabolism, we suggest that exposure to animal foods may favor an intestinal environment which could trigger systemic inflammation and insulin resistance-dependent metabolic disorders.Univ São Paulo, Sch Publ Hlth, Dept Epidemiol, Av Dr Arnaldo 715, BR-01246904 São Paulo, SP, BrazilUniv Fed São Paulo, Dept Prevent Med, Rua Botucatu 720, BR-04023900 São Paulo, SP, BrazilFundação Oswaldo Cruz, Rene Rachou Res Ctr, Av Augusto de Lima 1715, BR-30190002 Belo Horizonte, MG, BrazilUniv São Paulo, Med Sch, Lab Genet & Mol Cardiol, Heart Inst, Av Dr Eneas de Carvalho Aguiar,44,10 Andar, BR-05403000 São Paulo, SP, BrazilUniv Fed São Paulo, Dept Prevent Med, Rua Botucatu 720, BR-04023900 São Paulo, SP, BrazilWeb of ScienceFAPESPFAPESP: 2012/12626-9FAPESP: 2012/03880-9Biomed Central Ltd2019-08-19T11:49:44Z2019-08-19T11:49:44Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.1186/s13098-017-0261-xDiabetology & Metabolic Syndrome. London, v. 9, p. -, 2017.10.1186/s13098-017-0261-xWOS000407710800001.pdf1758-5996http://repositorio.unifesp.br/handle/11600/51391WOS:000407710800001ark:/48912/001300001rwqcenginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPFranco-de-Moraes, Ana Carolinade Almeida-Pititto, Bianca [UNIFESP]Fernandes, Gabriel da RochaGomes, Everton PadilhaPereira, Alexandre da CostaFerreira, Sandra Roberta G.2024-08-10T23:12:48Zoai:repositorio.unifesp.br:11600/51391Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-10T23:12:48Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition |
| title |
Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition |
| spellingShingle |
Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition Franco-de-Moraes, Ana Carolina Gut microbiota Diet Biomarkers Inflammation Insulin resistance |
| title_short |
Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition |
| title_full |
Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition |
| title_fullStr |
Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition |
| title_full_unstemmed |
Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition |
| title_sort |
Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition |
| dc.creator.none.fl_str_mv |
Franco-de-Moraes, Ana Carolina de Almeida-Pititto, Bianca [UNIFESP] Fernandes, Gabriel da Rocha Gomes, Everton Padilha Pereira, Alexandre da Costa Ferreira, Sandra Roberta G. |
| author |
Franco-de-Moraes, Ana Carolina |
| author_facet |
Franco-de-Moraes, Ana Carolina de Almeida-Pititto, Bianca [UNIFESP] Fernandes, Gabriel da Rocha Gomes, Everton Padilha Pereira, Alexandre da Costa Ferreira, Sandra Roberta G. |
| author_role |
author |
| author2 |
de Almeida-Pititto, Bianca [UNIFESP] Fernandes, Gabriel da Rocha Gomes, Everton Padilha Pereira, Alexandre da Costa Ferreira, Sandra Roberta G. |
| author2_role |
author author author author author |
| dc.subject.por.fl_str_mv |
Gut microbiota Diet Biomarkers Inflammation Insulin resistance |
| topic |
Gut microbiota Diet Biomarkers Inflammation Insulin resistance |
| description |
Aims: To describe the abundance of major phyla and some genera in the gut microbiota of individuals according to dietary habits and examine their associations with inflammatory markers, insulin resistance, and cardiovascular risk profile. Methods: A total of 268 non-diabetic individuals were stratified into groups of dietary types (strict vegetarians, lacto-ovo-vegetarians, and omnivores). The taxonomic composition and phylogenetic structure of the microbiota were obtained through the analysis of the 16S rRNA gene. Samples were clustered into operational taxonomic units at 97% similarity using GreenGenes 13.5 database. Clinical, biochemical, and circulating inflammatory markers were compared by ANOVA or Kruskal-Wallis test. Results: The sample (54.2% women, mean age 49.5 years) was composed of 66 strict vegetarians, 102 lacto-ovo-vegetarians and 100 omnivores. Considering the entire sample, the greatest abundant phyla were Firmicutes (40.7 +/- 15.9%) and Bacteroidetes (39.5 +/- 19.9%), and no difference in abundances was found between individuals with normal and excess weight. Stratifying by dietary types, the proportion of Firmicutes was lower and of Bacteroidetes was higher in strict vegetarians when compared to lacto-ovo-vegetarians and omnivores. At the genus level, strict vegetarians had a higher Prevotella abundance and Prevotella/Bacteroides ratio than the other groups. They also had a lower proportion of Faecalibacterium than lacto-ovo-vegetarians, and both vegetarian groups had higher proportions than did omnivores. Succinivibrio and Halomonas from the Proteobacteria phylum were overrepresented in omnivores. The omnivorous group showed higher values of anthropometric data, insulin, HOMA-IR, and a worse lipid profile. Inflammatory markers exhibited a gradual and significant increase from the vegetarians and lacto-ovo-vegetarians to the omnivorous group. Conclusions: There are differences in gut microbiota composition of individuals with distinct dietary habits, who differ according to their inflammatory and metabolic profiles. Based on the findings relative to bacteria abundances and on their recognized actions in the metabolism, we suggest that exposure to animal foods may favor an intestinal environment which could trigger systemic inflammation and insulin resistance-dependent metabolic disorders. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2019-08-19T11:49:44Z 2019-08-19T11:49:44Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/s13098-017-0261-x Diabetology & Metabolic Syndrome. London, v. 9, p. -, 2017. 10.1186/s13098-017-0261-x WOS000407710800001.pdf 1758-5996 http://repositorio.unifesp.br/handle/11600/51391 WOS:000407710800001 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/001300001rwqc |
| url |
http://dx.doi.org/10.1186/s13098-017-0261-x http://repositorio.unifesp.br/handle/11600/51391 |
| identifier_str_mv |
Diabetology & Metabolic Syndrome. London, v. 9, p. -, 2017. 10.1186/s13098-017-0261-x WOS000407710800001.pdf 1758-5996 WOS:000407710800001 ark:/48912/001300001rwqc |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
- application/pdf |
| dc.publisher.none.fl_str_mv |
Biomed Central Ltd |
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Biomed Central Ltd |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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