Combination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.

Department of Pharmaceutical Products. Faculty of Pharmacy. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.

Detalles Bibliográficos
Autores: Silva, Raphaela Ariany, Damasio, Danielle Soter, Coelho, Larissa Dutra, Teixeira, Eliane de Morais, Queiroz Junior, Celso M., Souza, Paulo Eduardo, Azevedo, Ricardo Bentes, Tedesco, Antônio, Ferreira, Lucas Antônio, Oliveira, Mônica Cristina, Aguiar, Marta Gontijo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:Brasil
Institución:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/64349
Acceso en línea:https://arca.fiocruz.br/handle/icict/64349
Access Level:acceso abierto
Palabra clave:chloroaluminum phthalocyanine
combined therapy
Cutaneous leishmaniasis
fexinidazole
liposomes
self-emulsifying drug release system
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dc.title.none.fl_str_mv Combination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.
title Combination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.
spellingShingle Combination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.
Silva, Raphaela Ariany
chloroaluminum phthalocyanine
combined therapy
Cutaneous leishmaniasis
fexinidazole
liposomes
self-emulsifying drug release system
title_short Combination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.
title_full Combination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.
title_fullStr Combination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.
title_full_unstemmed Combination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.
title_sort Combination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.
dc.creator.none.fl_str_mv Silva, Raphaela Ariany
Damasio, Danielle Soter
Coelho, Larissa Dutra
Teixeira, Eliane de Morais
Queiroz Junior, Celso M.
Souza, Paulo Eduardo
Azevedo, Ricardo Bentes
Tedesco, Antônio
Ferreira, Lucas Antônio
Oliveira, Mônica Cristina
Aguiar, Marta Gontijo
author Silva, Raphaela Ariany
author_facet Silva, Raphaela Ariany
Damasio, Danielle Soter
Coelho, Larissa Dutra
Teixeira, Eliane de Morais
Queiroz Junior, Celso M.
Souza, Paulo Eduardo
Azevedo, Ricardo Bentes
Tedesco, Antônio
Ferreira, Lucas Antônio
Oliveira, Mônica Cristina
Aguiar, Marta Gontijo
author_role author
author2 Damasio, Danielle Soter
Coelho, Larissa Dutra
Teixeira, Eliane de Morais
Queiroz Junior, Celso M.
Souza, Paulo Eduardo
Azevedo, Ricardo Bentes
Tedesco, Antônio
Ferreira, Lucas Antônio
Oliveira, Mônica Cristina
Aguiar, Marta Gontijo
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.en.none.fl_str_mv chloroaluminum phthalocyanine
combined therapy
Cutaneous leishmaniasis
fexinidazole
liposomes
self-emulsifying drug release system
topic chloroaluminum phthalocyanine
combined therapy
Cutaneous leishmaniasis
fexinidazole
liposomes
self-emulsifying drug release system
description Department of Pharmaceutical Products. Faculty of Pharmacy. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
publishDate 2024
dc.date.accessioned.fl_str_mv 2024-06-06T18:21:04Z
dc.date.available.fl_str_mv 2024-06-06T18:21:04Z
dc.date.issued.fl_str_mv 2024
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Raphaela Ariany et al. Combination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment. Pharmaceutics, v. 16, n. 4, p. 509, 2024. doi.org/10.3390/pharmaceutics16040509.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/64349
dc.identifier.issn.none.fl_str_mv 1999-4923
identifier_str_mv SILVA, Raphaela Ariany et al. Combination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment. Pharmaceutics, v. 16, n. 4, p. 509, 2024. doi.org/10.3390/pharmaceutics16040509.
1999-4923
url https://arca.fiocruz.br/handle/icict/64349
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MPDI
publisher.none.fl_str_mv MPDI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2024-06-06T18:21:04Z2024-06-06T18:21:04Z2024SILVA, Raphaela Ariany et al. Combination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment. Pharmaceutics, v. 16, n. 4, p. 509, 2024. doi.org/10.3390/pharmaceutics16040509.1999-4923https://arca.fiocruz.br/handle/icict/64349engMPDICombination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Pharmaceutical Products. Faculty of Pharmacy. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Department of Pharmaceutical Products. Faculty of Pharmacy. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Department of Pharmaceutical Products. Faculty of Pharmacy. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Clinical Research and Public Policy Group on Infectious and Parasitic Diseases. René Rachou Institute, Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Department of Morphology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Laboratory of Software and Instrumentation in Applied Physics and Laboratory of Electron Paramagnetic Resonance. Institute of Physics. University of Brasília. Brasília, DF, Brazil.Nanobiotechnology Laboratory. Institute of Biological Sciences. University of Brasília. Brasília, DF, Brazil.Department of Chemistry. Center of Nanotechnology and Tissue Engineering-Photobiology and Photomedicine Research Group. Faculty of Philosophy, Sciences and Letters of Ribeirão Preto. University of São Paulo. Ribeirão Preto , SP, Brazil.Department of Pharmaceutical Products. Faculty of Pharmacy. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Department of Pharmaceutical Products. Faculty of Pharmacy. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Department of Pharmaceutical Products. Faculty of Pharmacy. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Cutaneous leishmaniasis (CL) is a neglected tropical disease. The treatment is restricted to drugs, such as meglumine antimoniate and amphotericin B, that exhibit toxic effects, high cost, long-term treatment, and limited efficacy. The development of new alternative therapies, including the identification of effective drugs for the topical and oral treatment of CL, is of great interest. In this sense, a combination of topical photodynamic therapy (PDT) with chloroaluminum phthalocyanine liposomes (Lip-ClAlPc) and the oral administration of a self-emulsifying drug delivery system containing fexinidazole (SEDDS-FEX) emerges as a new strategy. The aim of the present study was to prepare, characterize, and evaluate the efficacy of combined therapy with Lip-ClAlPc and SEDDS-FEX in the experimental treatment of Leishmania (Leishmania) major. Lip-ClAlPc and SEDDS-FEX were prepared, and the antileishmanial efficacy study was conducted with the following groups: 1. Lip-ClAlPc (0.05 mL); 2. SEDDS-FEX (50 mg/kg/day); 3. Lip-ClAlPc (0.05 mL)+SEDDS-FEX (50 mg/kg/day) combination; 4. FEX suspension (50 mg/kg/day); and 5. control (untreated). BALB/c mice received 10 sessions of topical Lip-ClAlPc on alternate days and 20 consecutive days of SEDDS-FEX or FEX oral suspension. Therapeutical efficacy was evaluated via the parasite burden (limiting-dilution assay), lesion size (mm), healing of the lesion, and histological analyses. Lip-ClAlPc and SEDDS-FEX presented physicochemical characteristics that are compatible with the administration routes used in the treatments. Lip-ClAlPc+SEDDS-FEX led to a significant reduction in the parasitic burden in the lesion and spleen when compared to the control group (p < 0.05) and the complete healing of the lesion in 43% of animals. The Lip-ClAlPc+SEDDS-FEX combination may be promising for the treatment of CL caused by L. major.chloroaluminum phthalocyaninecombined therapyCutaneous leishmaniasisfexinidazoleliposomesself-emulsifying drug release systeminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZSilva, Raphaela ArianyDamasio, Danielle SoterCoelho, Larissa DutraTeixeira, Eliane de MoraisQueiroz Junior, Celso M.Souza, Paulo EduardoAzevedo, Ricardo BentesTedesco, AntônioFerreira, Lucas AntônioOliveira, Mônica CristinaAguiar, Marta GontijoLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/e334a1f7-ee24-49bd-a822-7844000a098c/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALCombination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.pdfCombination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.pdfapplication/pdf4718681https://arca.fiocruz.br/bitstreams/fc2e04dc-d603-40c5-b567-4a00f1ed350c/download30ca31c6b9f5e2af2cc6943a8eaa56eaMD52trueAnonymousREADTEXTCombination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.pdf.txtCombination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.pdf.txtExtracted texttext/plain60175https://arca.fiocruz.br/bitstreams/1003780d-eb3a-48ae-afc5-b9249c0feeca/download5b3c83b2cf5785582ff438b4743d7091MD511falseAnonymousREADTHUMBNAILCombination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.pdf.jpgCombination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment.pdf.jpgGenerated Thumbnailimage/jpeg45226https://arca.fiocruz.br/bitstreams/062aac9c-cd6e-48e1-b07b-42749a4667e7/download5fa3e5a3fadd561b2d238ad568dc0174MD512falseAnonymousREADicict/643492025-12-10 14:03:43.024open.accessoai:arca.fiocruz.br:icict/64349https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-10T17:03:43Repositório Institucional da FIOCRUZ (ARCA) - 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