Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP

Acesso ao texto completo: http://onlinelibrary.wiley.com/doi/10.1002/jmv.22087/pdf

Detalles Bibliográficos
Autores: Grassi, Maria Fernanda Rios, Olavarria, Viviana Nilla, Kruschewsky, Ramon de Almeida, Mascarenhas, Rita Elizabeth, Dourado, Maria Inês Costa, Correia, Luis Cláudio Lemos, Costa, Carlos Maurıcio de Castro, Castro, Bernardo Galvão
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:Brasil
Institución:Universidade Federal da Bahia (UFBA)
Repositorio:Repositório Institucional da UFBA
Idioma:inglés
OAI Identifier:oai:repositorio.ufba.br:ri/3071
Acceso en línea:http://www.repositorio.ufba.br/ri/handle/ri/3071
Access Level:acceso abierto
Palabra clave:HTLV-1
Proviral Load
Biomarker
HAM/TSP
Brazil
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network_acronym_str BR
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dc.title.pt_BR.fl_str_mv Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP
dc.title.alternative.pt_BR.fl_str_mv J Med Virol
title Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP
spellingShingle Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP
Grassi, Maria Fernanda Rios
HTLV-1
Proviral Load
Biomarker
HAM/TSP
Brazil
title_short Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP
title_full Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP
title_fullStr Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP
title_full_unstemmed Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP
title_sort Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP
dc.creator.none.fl_str_mv Grassi, Maria Fernanda Rios
Olavarria, Viviana Nilla
Kruschewsky, Ramon de Almeida
Mascarenhas, Rita Elizabeth
Dourado, Maria Inês Costa
Correia, Luis Cláudio Lemos
Costa, Carlos Maurıcio de Castro
Castro, Bernardo Galvão
Grassi, Maria Fernanda Rios
Olavarria, Viviana Nilla
Kruschewsky, Ramon de Almeida
Mascarenhas, Rita Elizabeth
Dourado, Maria Inês Costa
Correia, Luis Cláudio Lemos
Costa, Carlos Maurıcio de Castro
Castro, Bernardo Galvão
author Grassi, Maria Fernanda Rios
author_facet Grassi, Maria Fernanda Rios
Olavarria, Viviana Nilla
Kruschewsky, Ramon de Almeida
Mascarenhas, Rita Elizabeth
Dourado, Maria Inês Costa
Correia, Luis Cláudio Lemos
Costa, Carlos Maurıcio de Castro
Castro, Bernardo Galvão
author_role author
author2 Olavarria, Viviana Nilla
Kruschewsky, Ramon de Almeida
Mascarenhas, Rita Elizabeth
Dourado, Maria Inês Costa
Correia, Luis Cláudio Lemos
Costa, Carlos Maurıcio de Castro
Castro, Bernardo Galvão
author2_role author
author
author
author
author
author
author
dc.subject.por.fl_str_mv HTLV-1
Proviral Load
Biomarker
HAM/TSP
Brazil
topic HTLV-1
Proviral Load
Biomarker
HAM/TSP
Brazil
description Acesso ao texto completo: http://onlinelibrary.wiley.com/doi/10.1002/jmv.22087/pdf
publishDate 2011
dc.date.accessioned.fl_str_mv 2011-10-04T14:10:14Z
dc.date.available.fl_str_mv 2011-10-04T14:10:14Z
dc.date.issued.fl_str_mv 2011
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/3071
dc.identifier.issn.none.fl_str_mv 0146-6615
dc.identifier.number.pt_BR.fl_str_mv v.83, n.7, p.1269-74, 2011.
identifier_str_mv 0146-6615
v.83, n.7, p.1269-74, 2011.
url http://www.repositorio.ufba.br/ri/handle/ri/3071
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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spelling 2011-10-04T14:10:14Z2011-10-04T14:10:14Z20110146-6615http://www.repositorio.ufba.br/ri/handle/ri/3071v.83, n.7, p.1269-74, 2011.Acesso ao texto completo: http://onlinelibrary.wiley.com/doi/10.1002/jmv.22087/pdfA high human T-cell lymphotropic virus type 1 (HTLV-1) proviral load is described in HTLV-1-associated diseases, especially HAM/TSP. However, the cut-off value to define high levels of HTLV-1 proviral load is not well established. 281 HTLV-1-infected patients from the HTLV reference center in Salvador, Brazil, were followed from 2005 to 2008. Patients were classified as asymptomatic, possible-, probable-, and definite-HAM/TSP, in accordance with diagnostic criteria proposed by De Castro-Costa et al. (2006): AIDS Res Hum Retroviruses 22:931–935. HTLV-1 proviral load was determined using real-time PCR. A receiver operator characteristic (ROC) curve was constructed using only asymptomatic individuals and definite-HAM/TSP patients. The ROC curve was used to predict the proviral load level that differentiates these two groups. Out of 281 patients, 189 were asymptomatic and 92 were diagnosed with HAM/TSP (22 possible, 23 probable, 47 definite). The mean HTLV-1 proviral load was higher in possible- (89,104 ± 93,006 copies/106 PBMC), -probable (175,854 ± 128,083 copies/106 PBMC), and definite-HAM/TSP patients (150,667 ± 122,320 copies/106 PBMC), when compared to asymptomatic individuals (27,178 ± 41,155 copies/106 PBMC) (P < 0.0001). A comparison of all HAM/TSP groups showed the highest proviral loads in probable-HAM/TSP patients, yet the differences in mean values were not statistically significant. The ROC curve suggested a value of 49,865 copies/106 PBMC, with 87% sensitivity (95% CI = 74–95) and 81% specificity (95% CI = 75–86), as the best proviral load cut-off point to differentiate definite HAM/TSP patients from asymptomatic individuals. HTLV-1 proviral loads are higher in groups of infected patients with neurological symptoms and may represent a relevant biological marker of disease progression.Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2011-10-04T14:10:14Z No. of bitstreams: 1 Abstarct Journal of Medical Virology 83.doc: 27136 bytes, checksum: a6d5746a0b92108d01cf09836bb30a2d (MD5)Made available in DSpace on 2011-10-04T14:10:14Z (GMT). No. of bitstreams: 1 Abstarct Journal of Medical Virology 83.doc: 27136 bytes, checksum: a6d5746a0b92108d01cf09836bb30a2d (MD5) Previous issue date: 2011New YorkHTLV-1Proviral LoadBiomarkerHAM/TSPBrazilHuman T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSPJ Med Virolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessGrassi, Maria Fernanda RiosOlavarria, Viviana NillaKruschewsky, Ramon de AlmeidaMascarenhas, Rita ElizabethDourado, Maria Inês CostaCorreia, Luis Cláudio LemosCosta, Carlos Maurıcio de CastroCastro, Bernardo GalvãoGrassi, Maria Fernanda RiosOlavarria, Viviana NillaKruschewsky, Ramon de AlmeidaMascarenhas, Rita ElizabethDourado, Maria Inês CostaCorreia, Luis Cláudio LemosCosta, Carlos Maurıcio de CastroCastro, Bernardo GalvãoORIGINALAbstarct Journal of Medical Virology 83.docAbstarct Journal of Medical Virology 83.docapplication/msword27136https://repositorio.ufba.br/bitstream/ri/3071/1/Abstarct%20Journal%20of%20Medical%20Virology%2083.doca6d5746a0b92108d01cf09836bb30a2dMD51LICENSElicense.txtlicense.txttext/plain1907https://repositorio.ufba.br/bitstream/ri/3071/2/license.txtff4bdd9ec3f07e45f5df2f357458313fMD52TEXTAbstarct Journal of Medical Virology 83.doc.txtAbstarct Journal of Medical Virology 83.doc.txtExtracted texttext/plain2087https://repositorio.ufba.br/bitstream/ri/3071/3/Abstarct%20Journal%20of%20Medical%20Virology%2083.doc.txt6cea2d490ffe6aaff43d7f72769bfcffMD53ri/30712022-07-05 14:03:28.664oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttps://repositorio.ufba.br/oai/requestrepositorio@ufba.bropendoar:19322022-07-05T17:03:28Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
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