Binary micellar solutions of poly (Ethylene Oxide)-poly(Styrene Oxide) copolymers with pluronic P123 : drug solubilisation and cytotoxicity studies

The non-commercial copolymers E45S8, E45S17 and their mixtures with Pluronic® P123 (E21P67E21) were studied as carriers of the model drug griseofulvin. Critical micelle concentration (cmc) (dye solubilisation method), drug solubilisation capacity (Scp and Sh) determined by ultraviolet-visible (UV-Vi...

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Autores: Oliveira, Samira A., Moura, Carolina L., Cavalcante, Igor M., Lopes, Amanda Araújo, Leal, Luzia Kalyne Almeida Moreira, Gramosa, Nilce V., Ribeiro, Maria E. N. P., França, Francisco C. F., Yeates, Stephen G., Ricardo, Nágila M. P. S.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Brasil
Recursos:Universidade Federal do Ceará (UFC)
Repositorio:Repositório Institucional da Universidade Federal do Ceará (UFC)
Idioma:inglés
OAI Identifier:oai:repositorio.ufc.br:riufc/19157
Acesso em linha:http://www.repositorio.ufc.br/handle/riufc/19157
Access Level:acceso abierto
Palavra-chave:Micelas
Griseofulvina
Griseofulvin
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oai_identifier_str oai:repositorio.ufc.br:riufc/19157
network_acronym_str BR
network_name_str Brasil
repository_id_str
dc.title.pt_BR.fl_str_mv Binary micellar solutions of poly (Ethylene Oxide)-poly(Styrene Oxide) copolymers with pluronic P123 : drug solubilisation and cytotoxicity studies
title Binary micellar solutions of poly (Ethylene Oxide)-poly(Styrene Oxide) copolymers with pluronic P123 : drug solubilisation and cytotoxicity studies
spellingShingle Binary micellar solutions of poly (Ethylene Oxide)-poly(Styrene Oxide) copolymers with pluronic P123 : drug solubilisation and cytotoxicity studies
Oliveira, Samira A.
Micelas
Griseofulvina
Griseofulvin
title_short Binary micellar solutions of poly (Ethylene Oxide)-poly(Styrene Oxide) copolymers with pluronic P123 : drug solubilisation and cytotoxicity studies
title_full Binary micellar solutions of poly (Ethylene Oxide)-poly(Styrene Oxide) copolymers with pluronic P123 : drug solubilisation and cytotoxicity studies
title_fullStr Binary micellar solutions of poly (Ethylene Oxide)-poly(Styrene Oxide) copolymers with pluronic P123 : drug solubilisation and cytotoxicity studies
title_full_unstemmed Binary micellar solutions of poly (Ethylene Oxide)-poly(Styrene Oxide) copolymers with pluronic P123 : drug solubilisation and cytotoxicity studies
title_sort Binary micellar solutions of poly (Ethylene Oxide)-poly(Styrene Oxide) copolymers with pluronic P123 : drug solubilisation and cytotoxicity studies
dc.creator.none.fl_str_mv Oliveira, Samira A.
Moura, Carolina L.
Cavalcante, Igor M.
Lopes, Amanda Araújo
Leal, Luzia Kalyne Almeida Moreira
Gramosa, Nilce V.
Ribeiro, Maria E. N. P.
França, Francisco C. F.
Yeates, Stephen G.
Ricardo, Nágila M. P. S.
author Oliveira, Samira A.
author_facet Oliveira, Samira A.
Moura, Carolina L.
Cavalcante, Igor M.
Lopes, Amanda Araújo
Leal, Luzia Kalyne Almeida Moreira
Gramosa, Nilce V.
Ribeiro, Maria E. N. P.
França, Francisco C. F.
Yeates, Stephen G.
Ricardo, Nágila M. P. S.
author_role author
author2 Moura, Carolina L.
Cavalcante, Igor M.
Lopes, Amanda Araújo
Leal, Luzia Kalyne Almeida Moreira
Gramosa, Nilce V.
Ribeiro, Maria E. N. P.
França, Francisco C. F.
Yeates, Stephen G.
Ricardo, Nágila M. P. S.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.por.fl_str_mv Micelas
Griseofulvina
Griseofulvin
topic Micelas
Griseofulvina
Griseofulvin
description The non-commercial copolymers E45S8, E45S17 and their mixtures with Pluronic® P123 (E21P67E21) were studied as carriers of the model drug griseofulvin. Critical micelle concentration (cmc) (dye solubilisation method), drug solubilisation capacity (Scp and Sh) determined by ultraviolet-visible (UV-Vis) spectroscopy and 1H nuclear magnetic resonance (1H NMR) and cytotoxicity (LDH activity in human neutrophils) were studied. E45S17 1.0 wt.% dispersions presented colloidal aggregates limiting its Scp in comparison to E45S8, but in 0.1 wt.% solutions this phenomenon seemed to be absent and E45S17 presented a higher Scp. The mixtures that showed the best Scp results contained 50% of P123 and presented low cmc. An evaluation of literature data suggested a minimum Em content of 62% in EmSn copolymers below which the increase of Sn length does not lead to an increase of Sh. The results suggested no toxicity of the copolymers on human neutrophils, supporting the use of P123 and poly(styrene oxide) containing copolymers as drug carriers.
publishDate 2015
dc.date.issued.fl_str_mv 2015-11
dc.date.accessioned.fl_str_mv 2016-08-18T16:32:39Z
dc.date.available.fl_str_mv 2016-08-18T16:32:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, S. A. et al. Binary micellar solutions of poly(Ethylene Oxide)-poly(Styrene Oxide) copolymers with pluronic P123 : drug solubilisation and cytotoxicity studies. Journal of the Brazilian Chemical Society, São Paulo, v. 26, n.11, nov. 2015.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufc.br/handle/riufc/19157
dc.identifier.issn.none.fl_str_mv Print version 0103-5053
On-line 1678-4790
identifier_str_mv OLIVEIRA, S. A. et al. Binary micellar solutions of poly(Ethylene Oxide)-poly(Styrene Oxide) copolymers with pluronic P123 : drug solubilisation and cytotoxicity studies. Journal of the Brazilian Chemical Society, São Paulo, v. 26, n.11, nov. 2015.
Print version 0103-5053
On-line 1678-4790
url http://www.repositorio.ufc.br/handle/riufc/19157
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Journal of the Brazilian Chemical Society
publisher.none.fl_str_mv Journal of the Brazilian Chemical Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
bitstream.url.fl_str_mv http://repositorio.ufc.br/bitstream/riufc/19157/1/2015_art_saoliveira.pdf
http://repositorio.ufc.br/bitstream/riufc/19157/2/license.txt
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repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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spelling 2016-08-18T16:32:39Z2016-08-18T16:32:39Z2015-11OLIVEIRA, S. A. et al. Binary micellar solutions of poly(Ethylene Oxide)-poly(Styrene Oxide) copolymers with pluronic P123 : drug solubilisation and cytotoxicity studies. Journal of the Brazilian Chemical Society, São Paulo, v. 26, n.11, nov. 2015.Print version 0103-5053On-line 1678-4790http://www.repositorio.ufc.br/handle/riufc/19157The non-commercial copolymers E45S8, E45S17 and their mixtures with Pluronic® P123 (E21P67E21) were studied as carriers of the model drug griseofulvin. Critical micelle concentration (cmc) (dye solubilisation method), drug solubilisation capacity (Scp and Sh) determined by ultraviolet-visible (UV-Vis) spectroscopy and 1H nuclear magnetic resonance (1H NMR) and cytotoxicity (LDH activity in human neutrophils) were studied. E45S17 1.0 wt.% dispersions presented colloidal aggregates limiting its Scp in comparison to E45S8, but in 0.1 wt.% solutions this phenomenon seemed to be absent and E45S17 presented a higher Scp. The mixtures that showed the best Scp results contained 50% of P123 and presented low cmc. An evaluation of literature data suggested a minimum Em content of 62% in EmSn copolymers below which the increase of Sn length does not lead to an increase of Sh. The results suggested no toxicity of the copolymers on human neutrophils, supporting the use of P123 and poly(styrene oxide) containing copolymers as drug carriers.Journal of the Brazilian Chemical SocietyMicelasGriseofulvinaGriseofulvinBinary micellar solutions of poly (Ethylene Oxide)-poly(Styrene Oxide) copolymers with pluronic P123 : drug solubilisation and cytotoxicity studiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccessOliveira, Samira A.Moura, Carolina L.Cavalcante, Igor M.Lopes, Amanda AraújoLeal, Luzia Kalyne Almeida MoreiraGramosa, Nilce V.Ribeiro, Maria E. N. P.França, Francisco C. F.Yeates, Stephen G.Ricardo, Nágila M. P. 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