NAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsia

Aim: We examined the relationships between visfatin/NAMPT and nitrite concentrations (a marker of nitric oxide [NO] formation) or sFlt-1 levels in 205 patients with preeclampsia (PE) responsive or nonresponsive to antihypertensive therapy, and whether NAMPT SNPs rs1319501 and rs3801266 affect nitrit...

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Bibliographic Details
Authors: Pereira, Daniela A., Sandrim, Valeria C. [UNESP], Palei, Ana C., Amaral, Lorena M., Belo, Vanessa A., Lacchini, Riccardo, Cavalli, Ricardo C., Tanus-Santos, Jose E., Luizon, Marcelo R.
Format: article
Status:Published version
Publication Date:2021
Country:Brasil
Institution:Universidade Estadual Paulista (UNESP)
Repository:Repositório Institucional da UNESP
Language:English
OAI Identifier:oai:repositorio.unesp.br:11449/207954
Online Access:http://dx.doi.org/10.2217/pgs-2021-0006
http://hdl.handle.net/11449/207954
Access Level:Open access
Keyword:antihypertensive agents
genetic polymorphisms
nicotinamide phosphoribosyltransferase
nitric oxide
pharmacogenetics
preeclampsia
sFlt-1
visfatin/NAMPT
Description
Summary:Aim: We examined the relationships between visfatin/NAMPT and nitrite concentrations (a marker of nitric oxide [NO] formation) or sFlt-1 levels in 205 patients with preeclampsia (PE) responsive or nonresponsive to antihypertensive therapy, and whether NAMPT SNPs rs1319501 and rs3801266 affect nitrite concentrations in PE and 206 healthy pregnant women. Patients & methods: Circulating visfatin/NAMPT and sFlt-1 levels were measured by ELISA, and nitrite concentrations by using an ozone-based chemiluminescence assay. Results: In nonresponsive PE patients, visfatin/NAMPT levels were inversely related to nitrite concentrations and positively related to sFlt-1 levels. NAMPT SNP rs1319501 affected nitrite concentrations in nonresponsive PE patients and was tightly linked with NAMPT functional SNPs in Europeans. Conclusion: NAMPT SNP rs1319501 and visfatin/NAMPT affect NO formation, sFlt-1 levels and antihypertensive therapy response in PE.

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