Determinação do valor da heptoglobina sérica para diagnóstico de hemólise na síndrome HELLP
Context: HELLP syndrome is a severe complication of pre-eclampsia, caracterized by hemolysis, elevated liver enzymes and low platelet count. Although there are standardized laboratory values that define the HELLP syndrome, the difficulty still exists for the characterization of hemolysis. PURPOSE: t...
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| Tipo de recurso: | tesis de maestría |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.unesp.br:11449/113896 |
| Acceso en línea: | http://hdl.handle.net/11449/113896 |
| Access Level: | acceso abierto |
| Palabra clave: | Mulheres grávidas Síndrome HELLP Pre-eclampsia Heptoglobinas Hemolise e hemolisinas Estudos transversais Hemolysis and hemolysins |
| Sumario: | Context: HELLP syndrome is a severe complication of pre-eclampsia, caracterized by hemolysis, elevated liver enzymes and low platelet count. Although there are standardized laboratory values that define the HELLP syndrome, the difficulty still exists for the characterization of hemolysis. PURPOSE: to evaluate the haptoglobin value to diagnose the hemolysis in HELLP syndrome. METHODS: transversal and prospective study of pregnant and postdelivery women with pre-eclampsia. Laboratory tests evaluated: serum haptoglobin. ROC curve to determine the cutoff value of haptoglobin in the diagnosis of hemolysis in HELLP syndrome. RESULTS: The haptoglobin value for hemolysis diagnosis in HELLP syndrome was 0.26 g / L. DISCUSSION: The best correlation was with haptoglobin and DHL, indicating that this is the best marker of intravascular hemolysis for the diagnosis of HELLP syndrome. CONCLUSION: Serum haptoglobin in cases of pre-eclampsia should be part of routine tests for diagnosis of intravascular hemolysis in HELLP syndrome |
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