Effect of a non-peptide angiotensin receptor antagonist on water intake caused by centrally administered carbachol in the rat
Angiotensin II (ANG II) administered centrally produces drinking by acting on subtype 1 ANG II (AT1) receptors. Carbachol, a cholinergic receptor agonist, also induces drinking behavior by a central action. In the present study we determined whether the response to carbachol also involves AT1 recept...
| Autores: | , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 1996 |
| País: | Brasil |
| Recursos: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/224035 |
| Acesso em linha: | http://hdl.handle.net/11449/224035 |
| Access Level: | acceso abierto |
| Palavra-chave: | angiotensin II angiotensin receptor antagonist AT1 receptor carbachol DUP-753 water intake |
| Resumo: | Angiotensin II (ANG II) administered centrally produces drinking by acting on subtype 1 ANG II (AT1) receptors. Carbachol, a cholinergic receptor agonist, also induces drinking behavior by a central action. In the present study we determined whether the response to carbachol also involves AT1 receptors. Male Holtzman rats (250-300 g) with stainless steel cannula implanted into the lateral ventricle (LV) were used. Water intake after injection of 0.15 M NaCl (1.0 μl) into the LV was 0.2 ± 0.01 ml/h (N = 8). The AT1 receptor antagonist DUP-753 (50 nmol/μl) injected into the LV reduced water intake induced by ANG II (10 nmol/μl) from 9.2 ± 1.4 to 0.4 ± 0.1 ml/h (N = 8), and water intake induced by carbachol (2 nmol/μl) from 9.8 ± 1.4 ml/h to 3.7 ± 0.8 ml/h (N = 8). These results suggest that AT1 receptors play a role in the drinking behavior observed after central cholinergic stimulation in rats. |
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