Interações potenciais entre os medicamentos comumente prescritos em cirurgia oral e os medicamentos em uso pelo paciente: estudo piloto
Introduction: The high prevalence of drug use in the Brazilian population can interfere with dental prescriptions. Objectives: To identify drugs being used by patients seen at a minor oral surgery clinic and to estimate the risks of potential drug interactions (DI) with drugs commonly prescribed in...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | Brasil |
| Institución: | Universidade Federal de Juiz de Fora (UFJF) |
| Repositorio: | HU Revista (Online) |
| Idioma: | portugués |
| OAI Identifier: | oai:periodicos.ufjf.br:article/37911 |
| Acceso en línea: | https://periodicos.ufjf.br/index.php/hurevista/article/view/37911 |
| Access Level: | acceso abierto |
| Palabra clave: | Pharmacology Surgery, Oral Adverse Drug Reaction Drug Interactions Farmacologia Cirurgia Bucal Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Interações Medicamentosas |
| Sumario: | Introduction: The high prevalence of drug use in the Brazilian population can interfere with dental prescriptions. Objectives: To identify drugs being used by patients seen at a minor oral surgery clinic and to estimate the risks of potential drug interactions (DI) with drugs commonly prescribed in surgical procedures. Materials and Methods: An analytical and cross-sectional pilot study was carried out, including 24 patients treated at the Oral Surgery Clinic of the Dental School of a Brazilian Federal University. Data were collected through an exploratory questionnaire. All drugs were classified in the Anatomical Therapeutic Chemical (ATC) system. Potential DI were analyzed in the Drugs® database after correlation between the drugs used by the patient and the drugs commonly prescribed in oral surgery. Results: There was a prevalence of 66.7% (n=16) in the use of at least 1 medication among patients seen at the oral surgery clinic, with a mean of 3.5 (±2.2) medications, with polypharmacy identified in 16.6% patients (n=4). Mean age of medication users was 52 (±16) years, totaling 56 medications. The most prevalent drugs were those acting on the nervous and cardiovascular systems. When the additions of drugs commonly prescribed in oral surgery (anti-inflammatory drugs, analgesics and antimicrobials) to the drugs used by the 16 patients were simulated, 75 different potential DI were identified, 61 (81%) of moderate severity and 14 (19%) of high gravity. The most frequent potential DIs were antihypertensives with anti-inflammatory drugs, while those of serious clinical importance involved centrally acting drugs and opioid analgesics. Conclusion: There was a high prevalence of medication use by patients seen at the oral surgery clinic, with a significant risk of interactions with prescribed medications in surgical procedures. |
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