P27(Kip1) is down-regulated in the endometrium of women with endometriosis

Objective: To evaluate p27 protein expression in the endometrium of women with endometriosis.Design: Transversal case-control study.Setting: Endometriosis Unit. Federal University of São Paulo, Brazil.Patient(s): Thirteen patients with stage I/II endometriosis, five with stage III/IV endometriosis,...

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Authors: Schor, Eduardo [UNIFESP], Silva, Ismael Dale C. G. da [UNIFESP], Sato, Helio [UNIFESP], Baracat, Edmund Chada [UNIFESP], Girao, Manoel Joao B. C. [UNIFESP], Freitas, Vilmon de [UNIFESP]
Format: article
Status:Published version
Publication Date:2009
Country:Brasil
Institution:Universidade Federal de São Paulo (UNIFESP)
Repository:Repositório Institucional da UNIFESP
Language:English
OAI Identifier:oai:repositorio.unifesp.br:11600/31333
Online Access:http://dx.doi.org/10.1016/j.fertnstert.2007.12.070
http://repositorio.unifesp.br/handle/11600/31333
Access Level:Open access
Keyword:Endometrium
endometriosis
P27
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spelling P27(Kip1) is down-regulated in the endometrium of women with endometriosisEndometriumendometriosisP27Objective: To evaluate p27 protein expression in the endometrium of women with endometriosis.Design: Transversal case-control study.Setting: Endometriosis Unit. Federal University of São Paulo, Brazil.Patient(s): Thirteen patients with stage I/II endometriosis, five with stage III/IV endometriosis, and 11 control subjects.Intervention(s): Endometrial biopsies were obtained from patients with proven endometriosis and women without disease at laparoscopy. P27 protein was immunolocalized in the biopsy tissues and quantified by light microscopy.Main Outcome Measure(s): Immunostaining scores of glandular and stromal cells in endometrial biopsies obtained from patients with confirmed endometriosis compared with those of healthy control women with normal pelvis at laparoscopy. the staining scores of stage I/II and stage III/IV patients and of both patient groups and the control group were compared.Result(s): the level of p27 protein expression observed in the control group, both in the stroma and in the endometrial glands, was significantly different from that observed in the endometriosis patient groups. Significant differences in p27 protein expression levels in the glandular epithelium and stroma were not observed among groups of patients with endometriosis.Conclusion(s): the decreased level of p27 protein in the endometrium, of women with endometriosis suggests that cell cycle alterations in the endometrial mucosa may be involved in the pathogenesis of this disease. (Fertil Steril (R) 2009;91:682-6. (C) 2009 by American Society for Reproductive Medicine.)Universidade Federal de São Paulo, Pelv Pain & Endometriosis Unit, Dept Gynecol, Escola Paulista Med, São Paulo, BrazilUniversidade Federal de São Paulo, Pelv Pain & Endometriosis Unit, Dept Gynecol, Escola Paulista Med, São Paulo, BrazilWeb of ScienceElsevier B.V.Universidade Federal de São Paulo (UNIFESP)2016-01-24T13:52:17Z2016-01-24T13:52:17Z2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion682-686http://dx.doi.org/10.1016/j.fertnstert.2007.12.070Fertility and Sterility. New York: Elsevier B.V., v. 91, n. 3, p. 682-686, 2009.10.1016/j.fertnstert.2007.12.0700015-0282http://repositorio.unifesp.br/handle/11600/31333WOS:000264143500006ark:/48912/001300002trg9engFertility and Sterilityinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPSchor, Eduardo [UNIFESP]Silva, Ismael Dale C. G. da [UNIFESP]Sato, Helio [UNIFESP]Baracat, Edmund Chada [UNIFESP]Girao, Manoel Joao B. C. [UNIFESP]Freitas, Vilmon de [UNIFESP]2023-01-27T22:45:16Zoai:repositorio.unifesp.br:11600/31333Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-01-27T22:45:16Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv P27(Kip1) is down-regulated in the endometrium of women with endometriosis
title P27(Kip1) is down-regulated in the endometrium of women with endometriosis
spellingShingle P27(Kip1) is down-regulated in the endometrium of women with endometriosis
Schor, Eduardo [UNIFESP]
Endometrium
endometriosis
P27
title_short P27(Kip1) is down-regulated in the endometrium of women with endometriosis
title_full P27(Kip1) is down-regulated in the endometrium of women with endometriosis
title_fullStr P27(Kip1) is down-regulated in the endometrium of women with endometriosis
title_full_unstemmed P27(Kip1) is down-regulated in the endometrium of women with endometriosis
title_sort P27(Kip1) is down-regulated in the endometrium of women with endometriosis
dc.creator.none.fl_str_mv Schor, Eduardo [UNIFESP]
Silva, Ismael Dale C. G. da [UNIFESP]
Sato, Helio [UNIFESP]
Baracat, Edmund Chada [UNIFESP]
Girao, Manoel Joao B. C. [UNIFESP]
Freitas, Vilmon de [UNIFESP]
author Schor, Eduardo [UNIFESP]
author_facet Schor, Eduardo [UNIFESP]
Silva, Ismael Dale C. G. da [UNIFESP]
Sato, Helio [UNIFESP]
Baracat, Edmund Chada [UNIFESP]
Girao, Manoel Joao B. C. [UNIFESP]
Freitas, Vilmon de [UNIFESP]
author_role author
author2 Silva, Ismael Dale C. G. da [UNIFESP]
Sato, Helio [UNIFESP]
Baracat, Edmund Chada [UNIFESP]
Girao, Manoel Joao B. C. [UNIFESP]
Freitas, Vilmon de [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.subject.por.fl_str_mv Endometrium
endometriosis
P27
topic Endometrium
endometriosis
P27
description Objective: To evaluate p27 protein expression in the endometrium of women with endometriosis.Design: Transversal case-control study.Setting: Endometriosis Unit. Federal University of São Paulo, Brazil.Patient(s): Thirteen patients with stage I/II endometriosis, five with stage III/IV endometriosis, and 11 control subjects.Intervention(s): Endometrial biopsies were obtained from patients with proven endometriosis and women without disease at laparoscopy. P27 protein was immunolocalized in the biopsy tissues and quantified by light microscopy.Main Outcome Measure(s): Immunostaining scores of glandular and stromal cells in endometrial biopsies obtained from patients with confirmed endometriosis compared with those of healthy control women with normal pelvis at laparoscopy. the staining scores of stage I/II and stage III/IV patients and of both patient groups and the control group were compared.Result(s): the level of p27 protein expression observed in the control group, both in the stroma and in the endometrial glands, was significantly different from that observed in the endometriosis patient groups. Significant differences in p27 protein expression levels in the glandular epithelium and stroma were not observed among groups of patients with endometriosis.Conclusion(s): the decreased level of p27 protein in the endometrium, of women with endometriosis suggests that cell cycle alterations in the endometrial mucosa may be involved in the pathogenesis of this disease. (Fertil Steril (R) 2009;91:682-6. (C) 2009 by American Society for Reproductive Medicine.)
publishDate 2009
dc.date.none.fl_str_mv 2009-03-01
2016-01-24T13:52:17Z
2016-01-24T13:52:17Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.fertnstert.2007.12.070
Fertility and Sterility. New York: Elsevier B.V., v. 91, n. 3, p. 682-686, 2009.
10.1016/j.fertnstert.2007.12.070
0015-0282
http://repositorio.unifesp.br/handle/11600/31333
WOS:000264143500006
dc.identifier.dark.fl_str_mv ark:/48912/001300002trg9
url http://dx.doi.org/10.1016/j.fertnstert.2007.12.070
http://repositorio.unifesp.br/handle/11600/31333
identifier_str_mv Fertility and Sterility. New York: Elsevier B.V., v. 91, n. 3, p. 682-686, 2009.
10.1016/j.fertnstert.2007.12.070
0015-0282
WOS:000264143500006
ark:/48912/001300002trg9
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fertility and Sterility
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
eu_rights_str_mv openAccess
rights_invalid_str_mv http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.format.none.fl_str_mv 682-686
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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score 15,300724

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