Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion
OBJECTIVES: This study was designed to investigate prevention of contralateral testicular injury with sildenafil citrate after unilateral testicular torsion/detorsion. METHODS: Thirty-seven adult male rats were divided into four groups: sham operated (group 1, n = 7), torsion/detorsion + saline (gro...
| Authors: | , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2011 |
| Country: | Brasil |
| Institution: | Universidade de São Paulo (USP) |
| Repository: | Clinics |
| Language: | English |
| OAI Identifier: | oai:revistas.usp.br:article/19466 |
| Online Access: | https://www.revistas.usp.br/clinics/article/view/19466 |
| Access Level: | Open access |
| Keyword: | Testicular torsion Ischemia-reperfusion damage Sildenafil citrate Rat |
| Summary: | OBJECTIVES: This study was designed to investigate prevention of contralateral testicular injury with sildenafil citrate after unilateral testicular torsion/detorsion. METHODS: Thirty-seven adult male rats were divided into four groups: sham operated (group 1, n = 7), torsion/detorsion + saline (group 2, n = 10), torsion/detorsion + 0.7 mg of sildenafil citrate (group 3, n = 10) and torsion/detorsion + 1.4 mg of sildenafil citrate (group 4, n = 10). Unilateral testicular torsion was created by rotating the right testis 720º in a clockwise direction for 2 h in other groups, except for group 1, which was served as sham group. After torsion (2 h) and detorsion (2 h) periods, rats were killed. RESULTS: The level of reduced glutathion (GSH) (p |
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